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a/Helmholtz/full_poposal/PEBA/Text_for_qualification-needs_and_planned-measures_updated.docx b/Helmholtz/full_poposal/PEBA/Text_for_qualification-needs_and_planned-measures_updated.docx new file mode 100644 index 0000000..7b11a57 Binary files /dev/null and b/Helmholtz/full_poposal/PEBA/Text_for_qualification-needs_and_planned-measures_updated.docx differ diff --git a/Helmholtz/full_poposal/PEBA/comments.odt b/Helmholtz/full_poposal/PEBA/comments.odt index 310262c..4d2c3d7 100644 Binary files a/Helmholtz/full_poposal/PEBA/comments.odt and b/Helmholtz/full_poposal/PEBA/comments.odt differ diff --git a/Helmholtz/full_poposal/TODO.txt b/Helmholtz/full_poposal/TODO.txt index 377e767..0a7f676 100644 --- a/Helmholtz/full_poposal/TODO.txt +++ b/Helmholtz/full_poposal/TODO.txt @@ -49,19 +49,24 @@ check: ``virtual'' diagnostic in plasma accelerators via inverse problem method --------------- Feedback: +?? should I write something about the leadership training cost in the proposal? + FOR: -all in Arial font 10pt +/all in Arial font 10pt /CV in 10pt? /pub_list to arial? /pub_list: mark corresponding author publication and check for first author in main author? -general data annex 1: pdf problems -> send to Manuela input data., passt-> must still send back ok +/general data annex 1: pdf problems -> send to Manuela input data., passt + proposal text: -comments by Anna + milestones +comments by Anna ++ milestones -Reviewer list missing +/Reviewer list missing -Peba document +/Peba document +/all solved, except for moderation course or alternative -> done diff --git a/Helmholtz/full_poposal/proposal_text/plots/gantt_HH.pdf b/Helmholtz/full_poposal/proposal_text/plots/gantt_HH.pdf index 22d1850..d1014ee 100644 Binary files a/Helmholtz/full_poposal/proposal_text/plots/gantt_HH.pdf and b/Helmholtz/full_poposal/proposal_text/plots/gantt_HH.pdf differ diff --git a/Helmholtz/full_poposal/proposal_text/plots/gantt_HH_old.pdf b/Helmholtz/full_poposal/proposal_text/plots/gantt_HH_old.pdf new file mode 100644 index 0000000..22d1850 Binary files /dev/null and b/Helmholtz/full_poposal/proposal_text/plots/gantt_HH_old.pdf differ diff --git a/Helmholtz/full_poposal/proposal_text/proposal.aux b/Helmholtz/full_poposal/proposal_text/proposal.aux index 8e86c0c..ef5b9ac 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.aux +++ b/Helmholtz/full_poposal/proposal_text/proposal.aux @@ -29,14 +29,14 @@ \citation{vozenin_towards_2022} \abx@aux@cite{0}{vozenin_towards_2022} \abx@aux@segm{0}{0}{vozenin_towards_2022} -\@writefile{toc}{\contentsline {section}{\numberline {4}Current State of Research and Preliminary Work}{5}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {4.1}State of the art: radiotherapy}{5}{}\protected@file@percent } \citation{vozenin_towards_2022} \abx@aux@cite{0}{vozenin_towards_2022} \abx@aux@segm{0}{0}{vozenin_towards_2022} \citation{atkinson_current_2023} \abx@aux@cite{0}{atkinson_current_2023} 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LaTeX Warning: `!h' float specifier changed to `!ht'. -[12<./plots/linac_long+trans_axis.png>] [13<./plots/linac_diagnostics_labeled.pn -g>] - -File: plots/linac_inverse.png Graphic file (type png) - -Package luatex.def Info: plots/linac_inverse.png used on input line 639. -(luatex.def) Requested size: 432.48051pt x 89.12245pt. - + File: plots/gantt_HH.pdf Graphic file (type pdf) -Package luatex.def Info: plots/gantt_HH.pdf used on input line 657. -(luatex.def) Requested size: 455.24411pt x 339.17662pt. - [14<./plots/linac_inverse.png>] [15<./plots/gantt_HH.pdf>] [16] [17] +Package luatex.def Info: plots/gantt_HH.pdf used on input line 651. +(luatex.def) Requested size: 455.24411pt x 352.6454pt. +[13] [14<./plots/linac_inverse.png><./plots/gantt_HH.pdf>] [15] [16] [17] [18] Class scrartcl Warning: Incompatible usage of \@ssect detected. @@ -1063,17 +1058,17 @@ Class scrartcl Warning: Incompatible usage of \@ssect detected. (scrartcl) from within a non compatible caller, that does not (scrartcl) \scr@s@ct@@nn@m@ locally. (scrartcl) This could result in several error messages on input li -ne 907. +ne 933. [19] -Overfull \hbox (0.22868pt too wide) in paragraph at lines 908--908 +Overfull \hbox (0.22868pt too wide) in paragraph at lines 934--934 []\TU/Arial(0)/m/n/8 M. Brosi. ``Overview of the Micro-Bunching In-sta-bil-ity in Elec-tron Stor-age Rings and Evolv-ing Di-ag-nos-tics''. In: \TU/Arial(0)/m/ it/8 Proc. IPAC’21\TU/Arial(0)/m/n/8 . [] -Overfull \hbox (15.46355pt too wide) in paragraph at lines 908--908 +Overfull \hbox (15.46355pt too wide) in paragraph at lines 934--934 \TU/Arial(0)/m/n/8 Beam Ther-apy Based on HV-CMOS Pixel De-tec-tors''. In: \TU/ Arial(0)/m/it/8 In-stru-ments \TU/Arial(0)/m/n/8 7.1 (Feb. 2023), p. 9. DOI: $\ TU/lmtt/m/n/8 10 . 3390 / instruments7010009$\TU/Arial(0)/m/n/8 . @@ -1096,20 +1091,20 @@ Package logreq Info: Writing requests to 'proposal.run.xml'. ) (\end occurred inside a group at level 1) -### simple group (level 1) entered at line 506 ({) +### simple group (level 1) entered at line 507 ({) ### bottom level Here is how much of LuaTeX's memory you used: - 19091 strings out of 477805 - 195332,1373583 words of node,token memory allocated + 19093 strings out of 477805 + 195338,1373583 words of node,token memory allocated 596 words of node memory still in use: 3 hlist, 1 vlist, 1 rule, 6 glue, 3 kern, 1 glyph, 10 attribute, 75 glue_spec , 10 attribute_list, 2 write nodes - avail lists: 1:6,2:2544,3:997,4:159,5:90,6:198,7:19184,8:90,9:1344,10:46,11:1 -358,12:1 - 39278 multiletter control sequences out of 65536+600000 + avail lists: 1:3,2:2544,3:997,4:162,5:91,6:200,7:19184,8:90,9:1352,10:47,11:1 +353,12:1 + 39280 multiletter control sequences out of 65536+600000 61 fonts using 7236207 bytes - 108i,13n,100p,10602b,1242s stack positions out of 5000i,500n,10000p,200000b,80000s + 108i,13n,100p,10602b,1244s stack positions out of 5000i,500n,10000p,200000b,80000s -Output written on proposal.pdf (20 pages, 3056350 bytes). +Output written on proposal.pdf (20 pages, 3086419 bytes). -PDF statistics: 186 PDF objects out of 1000 (max. 8388607) - 105 compressed objects within 2 object streams +PDF statistics: 196 PDF objects out of 1000 (max. 8388607) + 110 compressed objects within 2 object streams 0 named destinations out of 1000 (max. 131072) 61 words of extra memory for PDF output out of 10000 (max. 100000000) diff --git a/Helmholtz/full_poposal/proposal_text/proposal.pdf b/Helmholtz/full_poposal/proposal_text/proposal.pdf index de07a0f..bf2b759 100644 Binary files a/Helmholtz/full_poposal/proposal_text/proposal.pdf and b/Helmholtz/full_poposal/proposal_text/proposal.pdf differ diff --git a/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz b/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz index 1837a7e..2ec6dc0 100644 Binary files a/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz and b/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz differ diff --git a/Helmholtz/full_poposal/proposal_text/proposal.tex b/Helmholtz/full_poposal/proposal_text/proposal.tex index 1ab9572..8437c55 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.tex +++ b/Helmholtz/full_poposal/proposal_text/proposal.tex @@ -9,7 +9,7 @@ \usepackage[]{fancyhdr} \usepackage{xcolor} \usepackage{lastpage} -\usepackage[top=2.5cm,bottom=2.5cm,left=2.5cm,right=2.5cm,footskip=1.5cm,headsep=0.8cm,headheight=1cm]{geometry} +\usepackage[top=2.5cm,bottom=2.cm,left=2.5cm,right=2.5cm,footskip=1.5cm,headsep=0.8cm,headheight=1cm]{geometry} \usepackage{graphicx}% Include figure files \usepackage{wrapfig} \usepackage{multirow} @@ -95,7 +95,7 @@ \fancyhead[R]{\color{gray}Page \thepage\ of \pageref{LastPage}} % \fancyfoot[L]{\color{gray}Page \thepage\ of \pageref{LastPage}} % \fancyhead[L]{\color{gray}\fontsize{9pt}{9pt}\selectfont\nouppercase{HIG: \thetitle}} -\fancyfoot[L]{\vspace{-0.5cm}\center\color{gray}\fontsize{9pt}{9pt}\selectfont\nouppercase{HIG: Beam Dynamics and Collective Effects in the Generation and Propagation of Structured Beams for\\ Advanced Accelerator-based Radiotherapy}} +\fancyfoot[L]{\vspace{-1.3cm}\center\color{gray}\fontsize{9pt}{9pt}\selectfont\nouppercase{HIG: Beam Dynamics and Collective Effects in the Generation and Propagation of Structured Beams for\\ Advanced Accelerator-based Radiotherapy}} \fancyhead[L]{\color{gray}\theauthor} \noindent @@ -114,10 +114,11 @@ Particle accelerators nowadays play a vital role in a multitude of scientific fi % \vspace{.5cm} \end{wrapfigure} -At the same time, the current development of two advanced approaches in accelerator-based radiotherapy (RT) pushes in the same direction of high intensity beams with temporal or spatial structuring. FLASH RT is based on the delivery of very high doses in short pulses and Microbeam RT focuses on spatially fractionated beams. In both methods, a significant widening of the therapeutic window is observed. The resulting normal tissue sparing effect is expected to improve treatment outcomes and reduce overall toxicity for the patients resulting in a better quality of life after treatment. The beam properties used for FLASH and Microbeam RT go beyond the prediction and beam diagnostic capabilities in conventional RT. One difficulty is the increasing non-linearity in the response of usual dosimetry methods at high dose-rates. The increased requirements on dosimetry as well as on the overall diagnostics and simulation of the beam dynamics in the accelerators used for beam generation open up new challenges and possibilities. At the same time, the extreme beam properties in the novel radiotherapy methods require to push the understanding of the involved complex beam dynamics and collective effects (Figure~\ref{wrap-fig:1}) in this active and exiting research field. +At the same time, the current development of two advanced approaches in accelerator-based radiotherapy (RT) pushes in the same direction of high intensity beams with temporal or spatial structuring. FLASH RT is based on the delivery of very high doses in short pulses and Microbeam RT focuses on spatially fractionated beams. In both methods, a significant widening of the therapeutic window is observed. The resulting normal tissue sparing effect is expected to improve treatment outcomes and reduce overall toxicity for the patients resulting in a better quality of life after treatment. The beam properties used for FLASH and Microbeam RT go beyond the prediction and beam diagnostic capabilities in conventional RT. One difficulty is the increasing non-linearity in the response of usual dosimetry methods at high dose-rates. The increased requirements on dosimetry as well as on the overall diagnostics and simulation of the beam dynamics in the accelerators used for beam generation open up new challenges and possibilities. At the same time, the extreme beam properties in the novel RT methods require to push the understanding of the involved complex beam dynamics and collective effects (Figure~\ref{wrap-fig:1}) in this active and exiting research field. The proposed project therefore aims at improving the understanding, predictability and control of the accelerator-based electron beams involved in FLASH and Microbeam RT. The entry point will be to extend the research on collective effects in accelerators to cover the beam properties required for FLASH and Microbeam RT, profiting from my expertise in this field. Subsequently, this project will expand the study beyond the particle accelerator into the beam-matter interaction up to the target tissue. The influence of collective effects during the transport from the accelerator through matter onto the target, which up until now was sparsely studied, will be explored in detail. Based on these studies, the effective relation of input particle distribution to the dose distribution on target will be explored. This enables, the attempt to solve the inverse problem, i.e. determining the required input distribution for a desired dose distribution on target. First tests of targeted beam shaping will be a part of this project. With this kind of control, the outcome of the project will be a significant contribution to FLASH and Microbeam RT as well as to the general advancement of accelerator physics. +\newpage \setcounter{tocdepth}{2} \tableofcontents @@ -125,9 +126,9 @@ The proposed project therefore aims at improving the understanding, predictabili % 2.2 Objectives -The extreme pulse properties in FLASH and Microbeam radiotherapy lead to several open questions to be answered. The high dose-rates achieved have a strong effect on the underlying mechanisms: from the improved biological interaction with healthy tissue being the main advantage and driving point, to the increased non-linearity in dosimetric measurements, high requirements in beam based diagnostics, and the presence of complex dynamics and self-interaction leading to collective effects in the accelerator-generated particle beams. Collective effects in radiotherapy beams have yet to be investigated. Thinking further, collective effects acting on the beam can lead to significant deformations of the charge distribution and therefore of the produced dose distribution, resulting in the need for mitigation or compensation and ideally shaping of the generated RT pulse. Which, under certain conditions, might be extendable to generate modulated beams for these novel radiotherapy methods directly in the accelerator. +The extreme pulse properties in FLASH and Microbeam radiotherapy lead to several open questions to be answered. The high dose-rates achieved have a strong effect on the underlying mechanisms: from the improved biological interaction with healthy tissue being the main advantage and driving point, to the increased non-linearity in dosimetric measurements, high requirements in beam based diagnostics, and the presence of complex dynamics and self-interaction leading to collective effects in the accelerator-generated particle beams. Collective effects in RT beams have yet to be investigated. Thinking further, collective effects acting on the beam can lead to significant deformations of the charge distribution and therefore of the produced dose distribution, resulting in the need for mitigation or compensation and ideally shaping of the generated RT pulse. Which, under certain conditions, might be extendable to generate modulated beams for these novel RT methods directly in the accelerator. -The main goal of the proposed project is to provide a fast and comprehensive assessment of radiotherapy beam properties and the resulting deposited dose on target as well as improved control thereof. +The main goal of the proposed project is to provide a fast and comprehensive assessment of RT beam properties and the resulting deposited dose on target as well as improved control thereof. Due to the high flexibility of electron research accelerators %and the possibilities of beam shaping at beam generation, this project primarily focuses on electron based beams, with the possibility for transfer later on to heavier particles. %, contributing to the active research conducted on FLASH and Microbeams RT. @@ -148,7 +149,7 @@ These objectives will be achieved by investigating the influence of collective e The outcome of the project will firstly be the results achieved in the work packages aiming for the four objectives given above. This will directly contribute to the advancement of the novel radiotherapy FLASH and Microbeam RT by improving the reliability of the medically crucial distribution on target by improving the prediction, precise diagnostic and targeted control of the used particle beam. The planned start-to-end simulation tool will allow to determine the expected particle and therefore dose distribution on the medical target with higher precision. This is accompanied by a in-depth and profound recommendation on applicable diagnostic methods for complex RT beams, and how they can be complemented by incorporating shot-to-shot accelerator diagnostics into the standard diagnostic portfolio. -The outcome of the investigation into targeted pulse shape control opens up new possibilities and approaches to generate the temporally and spatially modulated particle beams applied in novel radiotherapy methods. +The outcome of the investigation into targeted pulse shape control opens up new possibilities and approaches to generate the temporally and spatially modulated particle beams applied in novel RT methods. % \begin{itemize} @@ -234,7 +235,7 @@ In the medium to long term, the knowledge of critical parameters and understandi This Helmholtz Investigator Group proposal directly contributes in the Helmholtz Program ``Matter and Technology'', realized in the Research Field ``Matter'', in the Topic ``Accelerator Research and Development'' (ARD). This topic falls precisely in the research activities at the Institute for Beam Physics and Technology (IBPT), home to the KIT electron accelerators. One recent part of the subtopic 3 of ARD is the advancement of accelerator development by exploring novel use cases where radiotherapy is currently of high interest\footnote{9. Annual MT Meeting: \url{https://indico.desy.de/event/38765/contributions/152914/}}. -The research conducted in this project directly contributes to this topic with its main goal of furthering the accelerator physics side of novel radiotherapy methods like FLASH and Microbeam RT (as described in Section \ref{sec:goal_outcome}). +The research conducted in this project directly contributes to this topic with its main goal of furthering the accelerator physics side of novel RT methods like FLASH and Microbeam RT (as described in Section \ref{sec:goal_outcome}). To generate such custom beams the project will explore and develop possible methods to modulate and control pulse shapes. @@ -374,7 +375,7 @@ The initiators behind this program would welcome my contribution towards lecture % Additionally, members of the physics faculty such as dean of studies Prof. Dr. Quast and former vice-dean Prof. Dr. Husemann have declared their support for my involvement in a newly planned module of lectures on ``physical foundations of technologies''. -All of the above as well as the general wide variety of research fields at KIT promises multidisciplinary input and solution-finding in an inspiring, dynamic and nurturing environment for me to successfully establish myself as junior research group leader and for the project to provide an important contribution to accelerator science and towards the advancement of novel accelerator-based radiotherapy methods. +All of the above as well as the general wide variety of research fields at KIT promises multidisciplinary input and solution-finding in an inspiring, dynamic and nurturing environment for me to successfully establish myself as junior research group leader and for the project to provide an important contribution to accelerator science and towards the advancement of novel accelerator-based RT methods. % Even with KIT being my alma mater, I am convinced that KIT offers an unparalleled opportunity, based on the multidisciplinary research environment, the close collaboration with the university Heidelberg and the Heidelberg ion-therapy center and new additions such as the KIT-Center “Health Technologies” and is therefore the best-possible choice as host institution for the proposed project. @@ -387,7 +388,7 @@ All of the above as well as the general wide variety of research fields at KIT p \section{Current State of Research and Preliminary Work} \subsection{State of the art: radiotherapy} Radiotherapy (RT) has always been a very valuable tool in cancer treatment \cite{thariat_past_2013}%[1] -. In Europe, radiotherapy is recommended as part of the treatment plan for more than 50\% of cancer patients \cite{borras_need_2015}%[2] +. In Europe, RT is recommended as part of the treatment plan for more than 50\% of cancer patients \cite{borras_need_2015}%[2] . Reducing side effects while maintaining or even enhancing treatment efficacy in the future will improve the quality of life of the patients. Radiotherapy uses ionizing radiation to damage the DNA within the tumor cells, which prevents the cells from reproducing and eventually leads to their death. The external beam radiotherapy (EBRT) is based on accelerator-generated high-energy beams delivering a targeted dose of ionizing radiation to the affected area. As some areas of healthy tissue are unavoidable irradiated the dose rate is carefully chosen to keep a balance between tumor control and normal tissue tolerance. The range between radiation doses that effectively destroy cancer cells while only causing minimal damage to healthy tissue and organs is called the therapeutic window \cite{vozenin_towards_2022}%[3] . A widening of this window is one of the main goals of present day radiotherapy research. @@ -399,7 +400,7 @@ Radiotherapy (RT) has always been a very valuable tool in cancer treatment \cite \caption{Sketch of the therapeutic window increasing as normal tissue complication probability (NTCP) is shifted to higher dose for FLASH RT and tumor control probability (TCP) remains.} \label{fig:therapeutic_window} \end{figure} -allows a higher dose per fraction than in conventional radiotherapy without causing severe side effects, such as acute normal tissue reactions or long-term complications. Several suspected mechanisms behind the beneficial FLASH effect \cite{atkinson_current_2023} %[4] +allows a higher dose per fraction than in conventional RT without causing severe side effects, such as acute normal tissue reactions or long-term complications. Several suspected mechanisms behind the beneficial FLASH effect \cite{atkinson_current_2023} %[4] are being investigated. And while the exact mechanisms are not yet fully determined, the effect has been experimentally demonstrated for irradiation with photons, electrons and ions. The presented project will primarily focus on electron beams. The high dose rates result in difficulties with standard dosimetry techniques showing deviations from the required linear detection efficiency \cite{romano_ultrahigh_2022}%[5] @@ -420,13 +421,13 @@ and recent studies with protons showed promising results in the sparing of healt In summary, it can be concluded, that the high temporal or spatial structuring for both novel radiotherapy methods, FLASH RT and Microbeam RT, leads to an increased complexity in the diagnostics of the beam properties and the dose as well as in the generation. In addition to the capability to generate and diagnose beams for FLASH RT, also the beam dynamics under the extreme beam properties need to be investigated in great detail to understand and simulate the resulting effect on the beam properties on target. \subsection{State of the art: accelerators and collective effects} -As discussed above, the requirements of new advanced radiotherapy methods on particle accelerators are high and current research on FLASH RT is consequently mainly performed on dedicated accelerator research facilities with a focus on electron accelerators. The additional advantage is the possibility to benefit from the flexibility in operation parameters, such as variable pulse length or intensity, and the higher degree in versatile instrumentation and diagnostics. This allows systematic studies and parameter mappings to assist the search for the best suitable parameter set for a widening of the therapeutic window. Furthermore, at current RT accelerators, the diagnostic measures focus mainly on the dose detected after the accelerator. The wide range of fast and accurate diagnostics available and employed in research accelerators opens up access to fast and extensive information on the beam properties, such as charge, energy, position, pulse shape, and more \cite{schuller_european_2020}%[6] +As discussed above, the requirements of new advanced RT methods on particle accelerators are high and current research on FLASH RT is consequently mainly performed on dedicated accelerator research facilities with a focus on electron accelerators. The additional advantage is the possibility to benefit from the flexibility in operation parameters, such as variable pulse length or intensity, and the higher degree in versatile instrumentation and diagnostics. This allows systematic studies and parameter mappings to assist the search for the best suitable parameter set for a widening of the therapeutic window. Furthermore, at current RT accelerators, the diagnostic measures focus mainly on the dose detected after the accelerator. The wide range of fast and accurate diagnostics available and employed in research accelerators opens up access to fast and extensive information on the beam properties, such as charge, energy, position, pulse shape, and more \cite{schuller_european_2020}%[6] . The proposed project will exploit this further than currently done to increase the extend of monitoring and control over the produced pulses and to provide recommendations on the most suited, complementary diagnostics methods for RT. In general, research accelerators cover a wide variety of different use-cases and machine types, with circular and linear accelerators (linac) being the most common types. Overall, the beam properties can range from continuous beams to bunched beams consisting of particle packages (bunches), from MeV to several GeV or for colliders even TeV beam energies, from artificially elongated bunches with very narrow transverse sizes and divergence (ultra-low emittance \cite{apollonio_improved_2022}%[14] ) to wider but ultra-short bunches down to femtosecond pulse durations \cite{tavares_status_2019}%[15] . For electron accelerators, the electrons are either generated via thermionic emission or with a laser pulse on a photo-cathode. The latter case provides control over the pulse length as well as the transverse distribution of the generated initial electron bunch by modulating the incident laser pulse \cite{nabinger_transverse_2022}%[16] -. This offers further possibilities for studies of spatially structured pulses and the possibility for accelerator-based beam modulation of radiotherapy beams will be investigated within this project. +. This offers further possibilities for studies of spatially structured pulses and the possibility for accelerator-based beam modulation of RT beams will be investigated within this project. In a continuous effort, research accelerators are characterized to a higher and higher degree with regards to a wide variety of effects including complex contributions to the beam dynamics such as collective effects. In general, the dynamics of accelerated particles is influenced by fields of different origin. External magnetic fields are applied for guiding and focusing the particle beams as well as external electromagnetic fields which are used for the basic acceleration itself but also for fast deflection in the context of diagnostics or for shaping the longitudinal charge distribution by so-called higher harmonic cavities resulting in complex shapes of the electromagnetic potentials. These dynamic boundary conditions lead to complex, non-linear dynamics of the accelerated particles. On top of this, self-generated electromagnetic fields act back on the particles and on the surrounding material. These self-interactions and interactions with the environment depend on the number and distribution of the particles within a bunch and are therefore often referred to as collective effects \cite{brosi_-depth_2020}%[17] . @@ -463,7 +464,7 @@ Some of the aforementioned most pressing questions and challenges for accelerato In general, a sound understanding of the effects involved in the dynamics of temporally and spatially structured RT beams is required for the generation, the propagation as well as the detection of the resulting high dose-rate pulses. Identifying the contributing collective effects and shedding more light onto their deforming influence is therefore crucial to accurately predict the particle-, and therefore, dose-distribution on target. -\subsection{Previous relevant work on beam dynamics, collective effects and diagnostics by Dr. Brosi} +\subsection{Previous relevant work on beam dynamics, collective effects and diagnostics by Dr. Brosi\label{sec:relevant_work}} In the last years, I have performed systematic studies of the longitudinal as well as transverse collective effects and instabilities influencing the bunch shape in all dimensions. The main goal was to investigate phenomena occurring under extreme operation modes to understand and circumvent resulting performance limitations while contributing to the general advancement of the field. The studied conditions included high charge in single bunches, dedicated short bunch-length operation modes at the storage ring KARA \cite{brosi_systematic_2019} %[24] and small transverse bunch-sizes in the ultra-low emittance synchrotron light source MAX IV \cite{brosi_time-resolved_2023}%[21] , \cite{brosi_asymmetric_2024}%[22] @@ -539,11 +540,11 @@ To achieve the objectives, the work program is structured in the following work % \vspace{0.2cm} \subsection{WP A - Complex beam dynamics and collective effects} -As new, advanced radiotherapy modalities rely on high intensity, short and/or spatially structured particle beams, the influence of interactions between the beam-particles is significantly increased compared to conventional radiotherapy. Work package A will study the influence of these collective effects on the beam in the accelerator as well as during the beam transport through matter onto the irradiation target (Figure~\ref{fig:long_profil}). The focus will be on the influence the collective effects have on the spatial and temporal particle distribution within the beam, and therefore how the distribution on the target is affected, which is an important parameter in radiotherapy. +As new, advanced radiotherapy modalities rely on high intensity, short and/or spatially structured particle beams, the influence of interactions between the beam-particles is significantly increased compared to conventional RT. Work package A will study the influence of these collective effects on the beam in the accelerator as well as during the beam transport through matter onto the irradiation target (Figure~\ref{fig:long_profil}). The focus will be on the influence the collective effects have on the spatial and temporal particle distribution within the beam, and therefore how the distribution on the target is affected, which is an important parameter in radiotherapy. Sub-work package A1 will focus on the beam dynamics during the beam generation in the accelerator. As first step (WP A1.1), a case study will be conducted. The influence of collective effects during the generation of beams for FLASH and Microbeam RT based on accelerator parameters of proposed accelerator designs for dedicated FLASH accelerators, e.g. \cite{faillace_perspectives_2022}, will be simulated. A combination of established accelerator simulation tools, such as ASTRA, AT or Ocelot will be employed as each includes different implementations of different sets of collective effects. -WP A1.2 will use the linear accelerator FLUTE~\cite{nasse_flute_2013} at KIT as a testbed and compare measurements and simulations of different beam parameters resembling the desired radiotherapy beam properties. To this end, multiple different available operation modes in a wide parameter range will be evaluated to find a set of suitable conditions. Similar to WP A1.1, simulations of the beam dynamics will be conducted to understand and quantify the influence of of collective effects on the beam properties. Experimental measurements can be conducted with the existing, extensive accelerator diagnostic tools at FLUTE. The experimental measurements will overlap with the planned test in WP B1.1 on the applicability of accelerator diagnostics for these extreme beam properties. +WP A1.2 will use the linear accelerator FLUTE~\cite{nasse_flute_2013} at KIT as a testbed and compare measurements and simulations of different beam parameters resembling the desired RT beam properties. To this end, multiple different available operation modes in a wide parameter range will be evaluated to find a set of suitable conditions. Similar to WP A1.1, simulations of the beam dynamics will be conducted to understand and quantify the influence of of collective effects on the beam properties. Experimental measurements can be conducted with the existing, extensive accelerator diagnostic tools at FLUTE. The experimental measurements will overlap with the planned test in WP B1.1 on the applicability of accelerator diagnostics for these extreme beam properties. % \color{red}ADD THAT EFFECT ON DISTRIBUTION IS INVESTIGATED AS THIS IS VERY IMPORTANT\color{black} The second sub-work package (WP A2) will focus on the influence of the extreme beam properties (high intensity, temporally and spatially structured) on the beam-matter interaction on the way from the accelerator to the target tissue inside the patient. @@ -643,47 +644,62 @@ With this, control over the particle and therefore dose distribution on the targ \section{Work Plan} -\subsection{Time plan} +\subsection{Time plan and milestones} -% \color{blue} -The time line of the different work packages is displayed as a Gantt diagram in Figure \ref{fig:timeplan}. -The individual work packages are color-coded according to the responsible team member. In the lower part of the figure, the planned time frame of each team member within the project is depicted. -The exact time plan may be subject to change, depending on the research progresses. Any significant deviations from the original time plan will be communicated to the Helmholtz Association, in order to guarantee the best outcome for the project. - -% \color{black} - -\begin{figure}[t] +\begin{figure}[!b] \centering - \includegraphics[trim=0mm 0mm 0mm 0mm, clip,width=1\textwidth]{plots/gantt_HH.pdf} + \includegraphics[trim=2mm 1mm 0mm 0mm, clip,width=1\textwidth]{plots/gantt_HH.pdf} \caption{Time plan showing the individual work packages color-coded by responsible team member as well as the time frame of each team members within the project in the lower part.} \label{fig:timeplan} \end{figure} -\subsection{Group structure} +% \color{blue} +The time line of the different work packages as well as the milestones are displayed as a Gantt diagram in Figure \ref{fig:timeplan}. +For the project 6 milestones are defined, where the first milestone \textit{M1 - ``Impact of collective effects investigated''} concludes the investigation on the influence of collective effects on the particle distribution in RT beams within the accelerator in WP A1. +The second milestone \textit{M2 - ``Start-to-end simulation implemented''} will be reached upon finalizing the start-to-end simulation in WP A3 including also the effects of collective effects on the beam-matter interaction (WP A2). +The conclusion of the investigations on the pulse length dependence of diagnostics methods (WP B1 and B2.1+2) allows the recommendation of applicable diagnostics and represents the third milestone \textit{M3 - ``Recommendation of applicable diagnostics''}. +The fourth milestone \textit{M4 - ``Beam modulation/shaping demonstrated''} is achieved by demonstrating the possibility for modulation or shaping of the particle distribution in the accelerator (WP C1). +The implementation of a solution for the inverse problem (WP C3), to determine the required initial distribution for a custom final distribution on target, is a key milestone \textit{M5 - ``Solution to inverse problem implemented''}. +Finally, successfully testing the generation of custom particle distributions on the target by combining the results from WP C1, C2 and C3 completes the final milestone \textit{M6 - ``Proof-of-Principle custom shapes on target reached''}. -The work program is designed for me as group leader and a total of 2 postdoctoral researchers and 2 doctoral students. There will be one postdoctoral researcher and one doctoral student in the first haft of the project and the same number in the second half, with a year overlap between the doctoral students in year 3 (see Figure~\ref{fig:timeplan} lower part). + +In the Gantt diagram, the individual work packages are color-coded according to the responsible team member. In the lower part of the figure, the planned time frame of each team member within the project is depicted. +The exact time plan may be subject to change, depending on the research progresses. Any significant deviations from the original time plan will be communicated to the Helmholtz Association, in order to guarantee the best outcome for the project. + +% \color{black} + + + +\subsection{Group structure\label{sec:group_structure}} + +The work program is designed for me, as group leader, and a total of 2 postdoctoral researchers and 2 doctoral students. There will be one postdoctoral researcher and one doctoral student in the first haft of the project and the same number in the second half, with a year overlap between the doctoral students in year 3 (see Figure~\ref{fig:timeplan} lower part). To generally coordinate the work efforts and discuss outcomes and upcoming steps a weekly team meeting will be established. In addition, regular bi-weekly work package specific meetings will take place focusing on the respective challenges and problems to solve. For doctoral students, additionally, a weekly one-on-one meeting with me about their individual progress is intended which will give them the possibility to ask question in a more confidential and relaxed setting. In total, each team member should have no more than 3 regular meetings per week not including spontaneous discussions as well as more relaxed coffee break conversations. The work of this project will be distributed, as described in the following, onto the planned group members with the time schedule shown in the graph in Figure \ref{fig:timeplan}: \textbf{Doctoral student (PhD 1)} (starting between month 1 and 6, 3 years duration):\\ -Research topic: Experimental study of the influence of advanced radiotherapy beam properties such as short bunch length, charge, energy and transverse size on accelerator beam dynamics, diagnostics and detected dose. The research will mainly focus on experimental measurements of the effects of extreme beam properties at the linear accelerator FLUTE accompanied by supporting simulations and will contribute to work packages A1.2, A2.2, B1 and B2.1. +Research topic: Experimental study of the influence of advanced RT beam properties such as short bunch length, charge, energy and transverse size on accelerator beam dynamics, diagnostics and detected dose. The research will mainly focus on experimental measurements of the effects of extreme beam properties at the linear accelerator FLUTE accompanied by supporting simulations and will contribute to work packages A1.2, A2.2, B1 and B2.1. +The candidate should have some experience in experimental work, including setting up and handling sensitive diagnostic hardware. This topic offers a well-rounded package of tasks suited to result in a PhD thesis. It offers opportunities for the student to shape and combine different tasks according to their own vision to deliver the independent research results required for a dissertation, while still receiving the required guidance. \textbf{Doctoral student (PhD 2)} (starting month 25, 3 years duration):\\ -Research topic: Investigation of theoretical methods and algorithms to solve the inverse problem of custom accelerator-based beam modulation for advance radiotherapy. The main focus will be the theoretic work on a solution for WP C3 by finding an exploitable connection between the final particle distribution and the corresponding initial one. Therefore, the research will build on the start-to-end simulation from WP A3. It will likewise contribute to the simulation based tests while also closely collaborating on experimental tests in WP C4.1+4.2. +Research topic: Investigation of theoretical methods and algorithms to solve the inverse problem of custom accelerator-based beam modulation for advance radiotherapy. The main focus will be the theoretic work on a solution for WP C3 by finding an exploitable connection between the final particle distribution and the corresponding initial one. Therefore, the research will build on the start-to-end simulation from WP A3, for which the first postdoctoral researcher (see below) will be responsible, with whom the doctoral student will have half a year overlap. The doctoral student will furthermore contribute to the simulation based tests while also closely collaborating on experimental tests in WP C4.1+4.2. +A candidate is envisioned with a background or strong motivation in mathematical methods and computational physics. For this project the doctoral student would have the possibility and time to evaluate different possible methods towards their feasibility for the project objective IV. while collecting experience and in-depth knowledge in all of them. This will result for the project in a good overview of the available methods while also providing the student with a suitable amount of content for their PhD thesis and lets them gain a broad knowledge for their following career steps. + \textbf{Postdoctoral researcher (Postdoc 1)} (starting month 7, 2 years duration):\\ -Research topic: Establishing start-to-end simulation for beam transport of accelerator-generated novel RT beams. This will entail exploring methods to propagate structured beams through the accelerator as well as through matter, including not only single particle to matter interactions but also considering collective effects during the beam transport through matter. The research will include the work on WP A2.1+2.3 and will be the main contributor for WP A3. +Research topic: Establishing start-to-end simulation for beam transport of accelerator-generated novel RT beams. This will entail exploring methods to propagate structured beams through the accelerator as well as through matter, including not only single particle with matter interactions but also considering collective effects during the beam transport through matter. The research will include the work on WP A2.1+2.3 and will be the main contributor for WP A3. +The planned work will include the incorporation of collective effects into beam-matter interaction and the implementation of a start-to-end simulation combining beam transport simulations in the accelerator with simulations of the transport through matter. A candidate with a strong background in many-particle systems, radiation transport through matter, or, alternatively, theoretical accelerator physics with experience in simulation programming is envisioned. \textbf{Postdoctoral researcher (Postdoc 2)} (starting month 31, 2 years duration):\\ -Research topic: Experimental exploration of temporal and spatial shaping of accelerator beams and 2D particle and dose diagnostics. This position will cover the experimental work on possibilities for accelerator-based beam modulation (WP C1.2). The work will furthermore devise 2D diagnostics for the particle and dose distribution (WP B2.3 + B3) enabling the experimental observation of the deformation of the beam modulations during transport (WP C2.2). The postdoctoral researcher will work with the doctoral student (PhD 2) on testing the algorithms for targeted beam shapes (WP C4.1). +Research topic: Experimental exploration of temporal and spatial shaping of accelerator beams and 2D particle and dose diagnostics. This position will cover the experimental work on possibilities for accelerator-based beam modulation (WP C1.2). The work will furthermore devise 2D diagnostics for the particle and dose distribution (WP B2.3 + B3) enabling the experimental observation of the deformation of the beam modulations during transport (WP C2.2). The postdoctoral researcher will cooperate with the doctoral student (PhD 2) on testing the algorithms for targeted beam shapes (WP C4.1). +Due to the experimental nature of the assigned work packages, an experimental physicist with an extensive background in fast, time-resolved diagnostics and detectors as well as short pulse physics would be suitable. Alternatively, an electrical engineer working in detector development for 2-dimensional pulse detection with some basic experience in accelerator physics would be a good fit. \textbf{Group leader} (5 years):\\ -Besides my planned involvement in lectures, I, as group leader, will coordinate and be involved in all work packages as discussion partner and supervisor. Furthermore, I will take on the following work packages partially or fully: A1.1, A2.1 (partially), A2.3 (partially), B1.2 (partially), B1.3 (partially), B2.2, C1.1, C1.2 (partially), C2.1, C4.1 (partially), C4.2 (partially). +Besides my planned involvement in lectures, I, as group leader, will coordinate and be involved in all work packages as discussion partner and supervisor. Furthermore, I will take on the following work packages partially or fully: A1.1, A2.1 (partially), A2.3 (partially), B1.2 (partially), B1.3 (partially), B2.2, C1.1, C1.2 (partially), C2.1, C4.1 (partially), C4.2 (partially). These work packages will profit strongly from my knowledge of collective effects, their simulation as well as their experimental study (see Section~\ref{sec:relevant_work}). My experience in accelerator physics in general and in systematic data analysis and processing, will furthermore complement the skill set within the proposed group. -In shared work packages, the work will be distributed by subtopic and a close communication will be maintained with the corresponding team member. +In shared work packages, the work will be distributed by subtopic and a close communication will be maintained between the group leader and the corresponding team member. It is envisioned to give master students the possibility to contribute in different work packages. Possibilities would be, for example, in WP A3 (supervised by the first postdoctoral researcher) by testing different implementation possibilities for collective effects in beam-matter interactions, or setting up a new diagnostics system in the scope of WP B3 or also WP C2.2 supervised by the second postdoctoral researcher. It would offer a great opportunity for the postdoctoral researchers to gather experience in supervising students. Student assistants will support the project for example during experiments and measurement campaigns, with documentation, data organization or implementing specific data analysis scripts. % \color{blue} @@ -782,16 +798,24 @@ To lead the proposed project, the funding for the position as junior research gr % For the proposed work program the funding for two doctoral students, two postdoctoral researchers, and several student workers is included. -The first doctoral student will be employed for three years on a 75\% position and is planned to start shortly after the project start, latest after half a year (1-6 month after project start). The PhD thesis will be on the topic of: Experimental study of the influence of advanced radiotherapy beam properties such as short bunch length, charge, energy and transverse size on accelerator beam dynamics, diagnostics and detected dose. The candidate should have some experience in experimental work, including setting up and handling sensitive diagnostic hardware. This topic offers a round work package suited to result in a PhD thesis. It offers opportunities for the student to shape and combine different tasks according to their own vision to deliver the independent research results required for a dissertation, while still receiving the required guidance. - -The second doctoral student will be employed for three years on a 75\% position. This position should start in the beginning of project year three (24 month after project start). The work will focus on: Investigation of theoretical methods and algorithms to solve the inverse problem of custom accelerator-based beam modulation for advance radiotherapy. A candidate is envisioned with a background or strong motivation in mathematical methods and computational physics. For this project the doctoral student would have the possibility and time to evaluate different possible methods towards their feasibility for the project objective IV. while collecting experience and in-depth knowledge in all of them. This will result for the project in a good overview of the available methods while also providing the student with a broad knowledge for their following career steps. +The first doctoral student will be employed for three years on a 75\% position and is planned to start shortly after the project start, latest after half a year (1-6 month after project start). +%The PhD thesis will be on the topic of: Experimental study of the influence of advanced RT beam properties such as short bunch length, charge, energy and transverse size on accelerator beam dynamics, diagnostics and detected dose. +%The candidate should have some experience in experimental work, including setting up and handling sensitive diagnostic hardware. This topic offers a well-rounded work package suited to result in a PhD thesis. It offers opportunities for the student to shape and combine different tasks according to their own vision to deliver the independent research results required for a dissertation, while still receiving the required guidance. +% +The second doctoral student will be employed for three years on a 75\% position. This position should start in the beginning of project year three (24 month after project start). +%The work will focus on: Investigation of theoretical methods and algorithms to solve the inverse problem of custom accelerator-based beam modulation for advance radiotherapy. +%A candidate is envisioned with a background or strong motivation in mathematical methods and computational physics. For this project the doctoral student would have the possibility and time to evaluate different possible methods towards their feasibility for the project objective IV. while collecting experience and in-depth knowledge in all of them. This will result for the project in a good overview of the available methods while also providing the student with a broad knowledge for their following career steps. % For both doctoral students, to allow for some unplanned, but not uncommon, delays, due to e.g., unexpected down times of accelerators or other technical challenges, during the work on the PhD thesis, an additional, optional half year per doctoral position is requested, so that the contract could be extended to prevent financial stress for the students during the final stage of their thesis. -The first postdoctoral researcher will be employed for two years on a 100\% position and is planned to start after the first half of the first project year (6 month after project start). The planned work will include the incorporation of collective effects into beam-matter interaction and the implementation of a start-to-end simulation combining beam transport simulations in the accelerator with simulations of the transport through matter. A candidate with a strong background in many-particle systems, radiation transport through matter, or theoretical accelerator physics with experience in simulation programming is envisioned. The higher level of prior experience and knowledge required for this task, is more suited for a postdoctoral researcher position (compared to a doctoral student), which would furthermore allow the researcher to work as a more independent team member. +The first postdoctoral researcher will be employed for two years on a 100\% position and is planned to start after the first half of the first project year (6 month after project start). +%The planned work will include the incorporation of collective effects into beam-matter interaction and the implementation of a start-to-end simulation combining beam transport simulations in the accelerator with simulations of the transport through matter. A candidate with a strong background in many-particle systems, radiation transport through matter, or theoretical accelerator physics with experience in simulation programming is envisioned. +The higher level of prior experience and knowledge required for this task (see Section~\ref{sec:group_structure}), is more suited for a postdoctoral researcher position (compared to a doctoral student), which will furthermore allow the researcher to work as a more independent team member. -The second postdoctoral researcher will be employed with 100\% for two years and is planned to start in the second half of the third project year (30 month after project start). Due to the experimental nature of the assigned work packages, an experimental physicist with an extensive background in fast, time-resolved diagnostics and detectors as well as short pulse physics would be suitable. Alternatively, an electrical engineer working in detector development for 2-dimensional pulse detection with some basic experience in accelerator physics would be a good fit. In order to ensure a continuous progress in this stage of the project, the tasks should be carried out by a postdoctoral researcher who, due to previous experience can more efficiently solve upcoming challenges. Additionally, the project will benefit from the contribution of prior knowledge in fields such as detector engineering %and from the capability of the postdoctoral researcher to supervise a master student. -At the same time, would the increased independence of the postdoctoral researcher allow them to define their own research profile and gain experience in supervision. +The second postdoctoral researcher will be employed with 100\% for two years and is planned to start in the second half of the third project year (30 month after project start). +%Due to the experimental nature of the assigned work packages, an experimental physicist with an extensive background in fast, time-resolved diagnostics and detectors as well as short pulse physics would be suitable. Alternatively, an electrical engineer working in detector development for 2-dimensional pulse detection with some basic experience in accelerator physics would be a good fit. +In order to ensure a continuous progress in this stage of the project, the tasks (see Section~\ref{sec:group_structure}) should be carried out by a postdoctoral researcher who, due to previous experience can more efficiently solve upcoming challenges. Additionally, the project will benefit from the contribution of prior knowledge in fields such as detector engineering. %and from the capability of the postdoctoral researcher to supervise a master student. +At the same time, would the increased independence of the postdoctoral researcher allow them to define their own research profile and gain experience in the supervision of a potential master student. Additionally, some funds are requested to employ student assistants for a total of 3 years distributed over the project duration as required and interested students availability. The working time will be adjusted in such a way that the monthly salary corresponds to a “Minijob” (in 2024: €538/month maximum net salary) according to the customary rates for student assistants at KIT (in 2024: without completed master degree, €13.25/h netto). This results in a maximum of 40 working hours per month. The tasks will include support for setup, execution and documentation of experiments. @@ -838,7 +862,7 @@ A dedicated PC is forseen as control and read-out station for the experiments. T \subsubsection{Travel costs} -The participation in relevant conferences and workshops will enable the communication and discussion of results as well as help with establishing new connections and give access to the latest developments. For the travel to international conferences an average cost of €2500 is allocated, which also contains conference fees (e.g., typically around €700 for the international particle accelerator conference (IPAC)) and assumes a total trip duration of 6-7 days. For national travels an amount of €1500 is estimated to cover travels of up to 6 days. +The participation in relevant conferences and workshops is an important part in communicating results and exchanging ideas with colleagues from other research centers and facilities. For the travel to international conferences an average cost of €2500 is allocated, which also contains conference fees (e.g., typically around €700 for the international particle accelerator conference (IPAC)) and assumes a total trip duration of 6-7 days. For national travels an amount of €1500 is estimated to cover travels of up to 6 days. For me, in the role of group leader, an average of one international and one national trip per year is envisioned. For each doctoral researcher one international trip and two national trips are allocated within their contract duration, this could include a summer-school within Europe, e.g., Cern Accelerator School. For each postdoctoral researcher two international trips are planned. For all potential master students together, a total of three national trips to the DPG spring meetings are planned, to give them the possibility to present their research for the first time to a wider community out-side the university setting. % This amounts to following funds: @@ -855,6 +879,8 @@ For me, in the role of group leader, an average of one international and one nat % Master students (in total)&&3&4500\\ \hline % \end{tabular}} +In addition to the above travel costs, also the cost (including travel) for the program ``Leading your Group'' at the Helmholtz Leadership Academy is included in the allocated travel funds. + \section{Cooperations and Communication}\label{sec:collab} diff --git a/Helmholtz/full_poposal/proposal_text/proposal.toc b/Helmholtz/full_poposal/proposal_text/proposal.toc index e6b271b..438231a 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.toc +++ b/Helmholtz/full_poposal/proposal_text/proposal.toc @@ -7,12 +7,12 @@ \contentsline {subsection}{\numberline {4.3}Open questions and challenges}{8}{}% \contentsline {subsection}{\numberline {4.4}Previous relevant work on beam dynamics, collective effects and diagnostics by Dr. Brosi}{8}{}% \contentsline {section}{\numberline {5}Work Packages}{10}{}% -\contentsline {subsection}{\numberline {5.1}WP A - Complex beam dynamics and collective effects}{11}{}% +\contentsline {subsection}{\numberline {5.1}WP A - Complex beam dynamics and collective effects}{10}{}% \contentsline {subsection}{\numberline {5.2}WP B - Systematic investigation on temporal and spatial pulse shape dependence of detection mechanisms and diagnostic tools}{12}{}% \contentsline {subsection}{\numberline {5.3}WP C - Beam modulation and beam shaping}{13}{}% \contentsline {section}{\numberline {6}Work Plan}{14}{}% -\contentsline {subsection}{\numberline {6.1}Time plan}{14}{}% -\contentsline {subsection}{\numberline {6.2}Group structure}{14}{}% +\contentsline {subsection}{\numberline {6.1}Time plan and milestones}{14}{}% +\contentsline {subsection}{\numberline {6.2}Group structure}{15}{}% \contentsline {subsection}{\numberline {6.3}Research data management}{16}{}% \contentsline {subsection}{\numberline {6.4}Financial plan}{17}{}% \contentsline {subsubsection}{\numberline {6.4.1}Personnel costs}{17}{}% diff --git a/Helmholtz/full_poposal/reviewer.txt b/Helmholtz/full_poposal/reviewer.txt new file mode 100644 index 0000000..b44f20b --- /dev/null +++ b/Helmholtz/full_poposal/reviewer.txt @@ -0,0 +1,37 @@ + +Dr Deepa Angal-Kalinin (Clara). j +Edda Gschwendtner (CERN) die machen jedoch auch FLASH RT Studien in ihrer Gruppe j +Prof. Dr. A. Jankowiak (HZB, HU Berlin) j +Prof. Dr. Richard Walker (Diamond) j +Dr. Liu Lin, Head of Division in the Accelerator Division, at Laboratorio Nacional de Luz Sincrotron (Sirius) j + +Prof. Dr. Thorsten Kamps (HZB, HU Berlin) eventuell + + + +Dr. Markus Ries (Bessy) ? + + +Prof. Dr. Carsten P. Welsch (Liverpool) ? Wäre besser für Strahldiagnose +Dr. Ties Behnke (Desy) ist ein Detektor Spezialist + + +Dr. Riccardo Bartolini (DESY) besser nicht +Prof. Dr. Florian Grüner (Universität Hamburg (UHH)) besser nicht, hat seine Heimat in den LPA +Associate Professor Dr. Francesca Curbis (Lund University, MAX IV) (supervising current bachelor student together) gilt vermutlich als befangen + + +?Prof. Dr. Wim Leemans (Desy, Uni Hamburg) hier ein veto ;-) +?Dr. Montse Pont (Cells Alba) n + +?Prof. Dr. Andrea Denker (HZB, Berliner Hochschule für Technik, is Professor of "Accelerator Physics for Medicine", (Schwerpunkt Protontherapie) kene ich nicht; Du machst aber keine Protonen…ich weiss nicht, was ihre Einstellung dazu ist. https://www.helmholtz-berlin.de/pubbin/news_seite?nid=14955&sprache=en&seitenid=75923) + +Prof. Dr. Sverker Werin (Lund University, MAX IV) kenne ich nicht + +??Dr. Christelle Bruni (IJCLab?, Université Paris-Saclay), potentielle Konkurrenz? Kenne ich auch nicht + +Wie wäre es noch mit Angelès Faus-Golfe? Sie arbeiten in Orsay auch am einem Linac für Medizinzwecke… + +Oder Massimo Ferrario (Linacs & LPAs) und +Simone DiMitri (Linacs & Rings, elettra) +Vielleicht könnte man auch mal bei Matthias Fuchs fragen, wen er aus USA noch empfehlen würde? diff --git a/plasma/RevModPhys.90.035002.pdf b/plasma/RevModPhys.90.035002.pdf new file mode 100644 index 0000000..2b7a3fd Binary files /dev/null and b/plasma/RevModPhys.90.035002.pdf differ diff --git a/plasma/information-12-00061-v2.pdf b/plasma/information-12-00061-v2.pdf new file mode 100644 index 0000000..5c5a6db Binary files /dev/null and b/plasma/information-12-00061-v2.pdf differ diff --git a/plasma/qt3rx3c289_noSplash_dd98ebac5a87dac31f358e02c50d4d99.pdf b/plasma/qt3rx3c289_noSplash_dd98ebac5a87dac31f358e02c50d4d99.pdf new file mode 100644 index 0000000..5ab7666 Binary files /dev/null and b/plasma/qt3rx3c289_noSplash_dd98ebac5a87dac31f358e02c50d4d99.pdf differ diff --git a/plots/gantt_HH.pdf b/plots/gantt_HH.pdf index 22d1850..d1014ee 100644 Binary files a/plots/gantt_HH.pdf and b/plots/gantt_HH.pdf differ diff --git a/plots/gantt_HH.tex b/plots/gantt_HH.tex index 3529d43..0bfea1b 100644 --- a/plots/gantt_HH.tex +++ b/plots/gantt_HH.tex @@ -1,5 +1,11 @@ % \documentclass[4paper,11pt]{article} \documentclass{standalone} + +%only with lualatex +\usepackage{fontspec} +\setmainfont{Arial} +% + \usepackage{tikz} \usepackage{xcolor} \definecolor{phd1}{rgb}{0.125490196078431,0.290196078431373,0.529411764705882} % phd1 @@ -29,7 +35,7 @@ \usepackage{pgfgantt} \usepackage{helvet} -\renewcommand{\familydefault}{\sfdefault} +% \renewcommand{\familydefault}{\sfdefault} \makeatletter \newlength\pgf@pat@distance % or defined by the more portable \newdimen @@ -149,9 +155,10 @@ \begin{ganttchart}[expand chart=17cm, vgrid={*2{draw=none},{dotted}}, y unit title=0.6cm, - y unit chart=0.5cm, + y unit chart=0.42cm, title height=1, - bar height=0.6]{1}{30} + bar height=0.65, + Mile1/.style={milestone/.append style={fill=black}}]{1}{30} \gantttitle[]{Year 1}{6} \gantttitle[]{Year 2}{6} \gantttitle[]{Year 3}{6} @@ -161,28 +168,33 @@ \ganttbar[bar pattern={leader}]{WP A1.1}{1}{6} \\ \ganttbar[bar pattern={leader}]{WP A1.2}{1}{6}\ganttbar[bar pattern={phd1}]{}{7}{12} \\ + \ganttmilestone[Mile1]{M1}{12}\\ \ganttbar[bar pattern={leader}]{WP A2.1}{1}{3} \ganttbar[bar pattern={postdoc, leader}]{}{4}{9} \\ - \ganttbar[bar pattern={phd1, leader}]{WP A2.2}{4}{15} \\ - \ganttbar[bar pattern={leader,postdoc}]{WP A2.3}{4}{15} \\ - \ganttbar[bar pattern={postdoc}]{WP A3\phantom{.1}}{7}{15} + \ganttbar[bar pattern={phd1, leader}]{WP A2.2}{4}{12} \\ + \ganttbar[bar pattern={leader,postdoc}]{WP A2.3}{4}{12} \\ + \ganttbar[bar pattern={postdoc}]{WP A3\phantom{.1}}{7}{15}\\ + \ganttmilestone[Mile1]{M2}{15} \ganttnewline[ black] \ganttbar[bar pattern={phd1}]{WP B1.1}{1}{12} \\ \ganttbar[bar pattern={leader,phd1}]{WP B1.2}{10}{18} \\ % \ganttbar[bar pattern={leader,phd1}]{WP B1c}{10}{18} \\ \ganttbar[bar pattern={phd1}]{WP B2.1}{4}{15} \\ \ganttbar[bar pattern={leader}]{WP B2.2}{10}{18} \\ + \ganttmilestone[Mile1]{M3}{18}\\ \ganttbar[bar pattern={postdoc2}]{WP B2.3}{16}{21} \\ - \ganttbar[bar pattern={leader, postdoc2}]{WP B3\phantom{.1}}{19}{24} - \ganttnewline[ black] - \ganttbar[bar pattern={leader}]{WP C1.1}{13}{21} \\ - \ganttbar[bar pattern={postdoc2}]{WP C1.2}{16}{27} \\ + \ganttbar[bar pattern={leader, postdoc2}]{WP B3\phantom{.1}}{19}{24} \ganttnewline[ black] + \ganttbar[bar pattern={leader}]{WP C1.1}{13}{18} \\ + \ganttbar[bar pattern={postdoc2}]{WP C1.2}{16}{24} \\ + \ganttmilestone[Mile1]{M4}{24}\\ \ganttbar[bar pattern={leader}]{WP C2.1}{16}{21} \\ \ganttbar[bar pattern={postdoc2}]{WP C2.2}{19}{27} \\ \ganttbar[bar pattern={phd2}]{WP C3\phantom{.1}}{13}{27} \\ + \ganttmilestone[Mile1]{M5}{27}\\ \ganttbar[bar pattern={phd2, postdoc2, leader}]{WP C4.1}{22}{27}%\ganttbar[bar pattern={phd2,leader}]{}{25}{28} \ganttbar[bar pattern={phd2, leader}]{}{28}{30} \\ - \ganttbar[bar pattern={phd2, leader}]{WP C4.2}{25}{30} %\ganttbar[bar pattern={leader}]{}{28}{30} + \ganttbar[bar pattern={phd2, leader}]{WP C4.2}{25}{30} \\ + \ganttmilestone[Mile1]{M6}{30} \ganttnewline[very thick, black] \ganttbar[bar pattern={leader}]{Group leader}{1}{30} \\ \ganttbar[bar pattern={phd1}]{PhD 1}{1}{18} \\ @@ -197,8 +209,8 @@ % \ganttbar[bar pattern={phd1, phd2}]{WP3}{10}{30} \\ % \ganttbar[bar pattern={phd2}]{WP4}{20}{45} \end{ganttchart} - \node at (14.1, -2.1) {\textbf{WP A}}; - \node at (14.1, -5.2) {\textbf{WP B}}; - \node at (14.1, -8.3) {\textbf{WP C}}; -\end{tikzpicture} + \node at (14.1, -2.3) {\textbf{WP A}}; + \node at (14.1, -5.5) {\textbf{WP B}}; + \node at (14.1, -8.9) {\textbf{WP C}}; +\end{tikzpicture} \hspace{0.15cm} \end{document} diff --git a/plots/gantt_old.pdf b/plots/gantt_old.pdf new file mode 100644 index 0000000..7214250 Binary files /dev/null and b/plots/gantt_old.pdf differ