diff --git a/.gitignore b/.gitignore new file mode 100644 index 0000000..5eee5e4 --- /dev/null +++ b/.gitignore @@ -0,0 +1,4 @@ +*.aux +*.log +*.gz +*.~* diff --git a/Helmholtz/full_poposal/.~lock.53_05_en_elan_projectdescription_draft_formated.odt# b/Helmholtz/full_poposal/.~lock.53_05_en_elan_projectdescription_draft_formated.odt# deleted file mode 100644 index a61dfb9..0000000 --- a/Helmholtz/full_poposal/.~lock.53_05_en_elan_projectdescription_draft_formated.odt# +++ /dev/null @@ -1 +0,0 @@ -,mirbro,w-mirbro-pc-0,31.03.2024 17:05,file:///home/mirbro/.config/libreoffice/4; \ No newline at end of file diff --git a/Helmholtz/full_poposal/0_Center_Cover_letter_mbrosi.docx b/Helmholtz/full_poposal/0_Center_Cover_letter_mbrosi.docx new file mode 100644 index 0000000..c31e2b1 Binary files /dev/null and b/Helmholtz/full_poposal/0_Center_Cover_letter_mbrosi.docx differ diff --git a/Helmholtz/full_poposal/0_Center_Cover_letter_template_mbrosi.docx b/Helmholtz/full_poposal/0_Center_Cover_letter_template_mbrosi.docx index 19541c1..c31e2b1 100644 Binary files a/Helmholtz/full_poposal/0_Center_Cover_letter_template_mbrosi.docx and b/Helmholtz/full_poposal/0_Center_Cover_letter_template_mbrosi.docx differ diff --git a/Helmholtz/full_poposal/3_Miriam_Brosi_Annex_3_HIG-Terms-of-agreement_filledin_FOR.pdf b/Helmholtz/full_poposal/3_Miriam_Brosi_Annex_3_HIG-Terms-of-agreement_filledin_FOR.pdf new file mode 100644 index 0000000..58d9e39 Binary files /dev/null and b/Helmholtz/full_poposal/3_Miriam_Brosi_Annex_3_HIG-Terms-of-agreement_filledin_FOR.pdf differ diff --git a/Helmholtz/full_poposal/53_05_en_elan_projectdescription_draft_formated.odt b/Helmholtz/full_poposal/53_05_en_elan_projectdescription_draft_formated.odt index de9d92d..1ee40bd 100644 Binary files a/Helmholtz/full_poposal/53_05_en_elan_projectdescription_draft_formated.odt and b/Helmholtz/full_poposal/53_05_en_elan_projectdescription_draft_formated.odt differ diff --git a/Helmholtz/full_poposal/De Carne_Helmholtz_Proposal.pdf b/Helmholtz/full_poposal/De Carne_Helmholtz_Proposal.pdf index 3c549d1..9c27af7 100644 Binary files a/Helmholtz/full_poposal/De Carne_Helmholtz_Proposal.pdf and b/Helmholtz/full_poposal/De Carne_Helmholtz_Proposal.pdf differ diff --git a/Helmholtz/full_poposal/Finanz_verteilung_adjusted.ods b/Helmholtz/full_poposal/Finanz_verteilung_adjusted.ods new file mode 100644 index 0000000..ac556c7 Binary files /dev/null and b/Helmholtz/full_poposal/Finanz_verteilung_adjusted.ods differ diff --git a/Helmholtz/full_poposal/Fragen.txt b/Helmholtz/full_poposal/Fragen.txt index 8c6cac3..a229a88 100644 --- a/Helmholtz/full_poposal/Fragen.txt +++ b/Helmholtz/full_poposal/Fragen.txt @@ -1,49 +1,80 @@ FOR: -- financial plan: how to split the funding between Helmholtz institute, university and initiative and networking fund? - - -- cover letter: can be similar to internal support letter of institute? -- ": instructions in mail says to mention name of contact but the general point is made in the parts that should not be changed... - -- list of reviewers: in which sense unbiased, personally, scientifically? can it be people I worked with. Or people who I plan to work with in the context of the project? -Are people at HH Centers biased as their centrum potentially also submits candidates for a HIG? - -- list of reviewers: same as for mid term evaluation? - -- is there a layout/structure I have to follow for the proposal text? - -- university partner? - -- wie publicationen zählen? welche typen... - -- Have you been informed about the evaluation procedure, regulations, and the probability -of reaching the offered permanent position by the Helmholtz Center? - -- Upon positive evaluation, what will your employment position be: (how specific does this need to be?) - -- Intended project start (dd/mm/yyyy) - -- List of publications incl. h-Index (please highlight peer-reviewed and first or corresponding author publications), awards and patents (if applicable) - what should go in? and how long can it be? - - -- muss Arial? oder nur nix was kleiner ist? ---------------------------- - - -Anke: - -- career plan, was ist drin? kann sie professor versprechen? - -- cover letter needs to be done together, similar to support letter? was mit pof und helmholtz einordnung.... - -- Helmholtz Program-orientied funding stream (PoF) ?? - -- Intended project start (dd/mm/yyyy) - ----------- - +/- financial plan: how to split the funding between Helmholtz institute, university and initiative and networking fund? A Helmholtz Investigator Group may be based at a university, a Helmholtz Center, or both. However, the group is expected to agree on clearly defined tasks at each of the institutions. These tasks must be set out in detail in the planned work schedule. --> muss ich den workplan in verschiedene bereiche einteilen? +-> muss ich den workplan in verschiedene bereiche einteilen? ->(alles eins KIT) + + +/- cover letter: can be similar to internal support letter of institute? +/- ": instructions in mail says to mention name of contact but the general point is made in the parts that should not be changed...(no need for that) + +- list of reviewers: in which sense unbiased, personally, scientifically? can it be people I worked with. Or people who I plan to work with in the context of the project? +Are people at HH Centers biased as their centrum potentially also submits candidates for a HIG? - have worked with them, no coauthors..., or relationship + +- list of reviewers: same as for mid term evaluation? -> not sure but probably not + +/- is there a layout/structure I have to follow for the proposal text? -> no + +/- university partner? KIT? -> all in one, no need to distinguish + +- Helmholtz Program-orientied funding stream (PoF) ?? + +/- wie publicationen zählen? welche typen... ->vlt mit klammer für unterscheidung + +/- Upon positive evaluation, what will your employment position be: (how specific does this need to be?) -> E14 mindestens nicht klar ob der rest fest gelegt oder nur in aussicht gestellt? + +/- Intended project start (dd/mm/yyyy) -> guess + +/- List of publications incl. h-Index (please highlight peer-reviewed and first or corresponding author publications), awards and patents (if applicable) - what should go in? and how long can it be? + +- muss Arial? oder nur nix was kleiner ist? +--------------------------- +https://www.dkfz.de/en/medizinische-physik-radioonkologie/flash_workshop2024.html + +Anke: + +/- cover letter needs to be done together, similar to support letter? was mit pof und helmholtz einordnung.... + +/- career plan, was ist drin? kann sie professor versprechen? + +- list of reviewers: in which sense unbiased, personally, scientifically? can it be people I worked with. Or people who I plan to work with in the context of the project? +Are people at HH Centers biased as their centrum potentially also submits candidates for a HIG? - have worked with them, no coauthors..., or relationship + +- Helmholtz Program-orientied funding stream (PoF) ?? + +/- Intended project start (dd/mm/yyyy) mai, darf leute auf anke erstmal anstellen + +/- funding split important for host institute? could be 50% or by topic + +/- contact person(s)? in terms of Agreement + +Dr Deepa Angal-Kalinin (Clara) +Edda Gschwendtner (CERN) aber die machen auch FLASH nun +Prof. Dr. A. Jankowiak (HZB, HU Berlin) +Dr. Markus Ries (Bessy) +Prof. Dr. Thorsten Kamps (HZB, HU Berlin) +Prof. Dr. Carsten P. Welsch (Liverpool) +Associate Professor Dr. Francesca Curbis (Lund University) +Prof. Dr. Richard Walker (Diamond) +Dr. Liu Lin, Head of Division in the Accelerator Division, at Laboratorio Nacional de Luz Sincrotron (Sirius) +Dr. Riccardo Bartolini (DESY) +?Dr. Montse Pont (Cells Alba) +? Prof. Dr. Andrea Denker (HZB, is Professor of "Accelerator Physics for Medicine", https://www.helmholtz-berlin.de/pubbin/news_seite?nid=14955&sprache=en&seitenid=75923) + +berliner profs +eleonore ? - coauthor +shaukart? -coauthor + + +---------- +PEBA + +- wie lange am kit bevor berufung??...nicht klar + +- Keine fixe aussage vom Bereich bisher.... + +- Have you been informed about the evaluation procedure, regulations, and the probability +of reaching the offered permanent position by the Helmholtz Center? -> PEBA -> wissen es auch nicht... + diff --git a/Helmholtz/full_poposal/HIG-Financial-Plan_annex2.xlsx b/Helmholtz/full_poposal/HIG-Financial-Plan_annex2.xlsx index d36bdce..a10f54c 100644 Binary files a/Helmholtz/full_poposal/HIG-Financial-Plan_annex2.xlsx and b/Helmholtz/full_poposal/HIG-Financial-Plan_annex2.xlsx differ diff --git a/Helmholtz/full_poposal/HIG-General-data_annex1.pdf b/Helmholtz/full_poposal/HIG-General-data_annex1.pdf index 8de5487..f9d75dd 100644 Binary files a/Helmholtz/full_poposal/HIG-General-data_annex1.pdf and b/Helmholtz/full_poposal/HIG-General-data_annex1.pdf differ diff --git a/Helmholtz/full_poposal/PEBA/2024_Competence Profile for Scientists_engl.pdf b/Helmholtz/full_poposal/PEBA/2024_Competence Profile for Scientists_engl.pdf index 942b09b..652993a 100644 Binary files a/Helmholtz/full_poposal/PEBA/2024_Competence Profile for Scientists_engl.pdf and b/Helmholtz/full_poposal/PEBA/2024_Competence Profile for Scientists_engl.pdf differ diff --git a/Helmholtz/full_poposal/PEBA/2024_Reply_PEBA_Miriam_Brosi.docx b/Helmholtz/full_poposal/PEBA/2024_Reply_PEBA_Miriam_Brosi.docx new file mode 100644 index 0000000..b789898 Binary files /dev/null and b/Helmholtz/full_poposal/PEBA/2024_Reply_PEBA_Miriam_Brosi.docx differ diff --git a/Helmholtz/full_poposal/PEBA/2024_Reply_PEBA_your name.docx b/Helmholtz/full_poposal/PEBA/2024_Reply_PEBA_your name.docx deleted file mode 100644 index e15bd2f..0000000 Binary files a/Helmholtz/full_poposal/PEBA/2024_Reply_PEBA_your name.docx and /dev/null differ diff --git a/Helmholtz/full_poposal/TODO.txt b/Helmholtz/full_poposal/TODO.txt index 2ae3ee9..828c58f 100644 --- a/Helmholtz/full_poposal/TODO.txt +++ b/Helmholtz/full_poposal/TODO.txt @@ -1,11 +1,12 @@ -PEBA document - needs info which kind of position is envisioned? +/ PEBA document - needs info which kind of position is envisioned? ------------- -1. Center cover letter - me with institute +/ 1. Center cover letter - me with institute - sent to Anke 2. Application (research proposal, incl. CV, list of publications and awards, as one file) - me +->> energy efficiency see info in HIG-call.pdf /- List of publications incl. h-Index (please highlight peer-reviewed and first or corresponding author publications), !awards! and patents (if applicable) /- CV (no more than 3 pages, Arial 10 pt.; incl. supervision experiences) @@ -13,23 +14,24 @@ see info in HIG-call.pdf 3. General data (Annex 1) - me with consultation with institute - summary in 200 words (eng. deutsch) +/4. Financial plan (Annex 2) - me with consultation with institute +-> leadership course verteilt drin + 3% pro jahr, 50k übrig momentan -4. Financial plan (Annex 2) - me with consultation with institute - - -5. Confirmation of terms of agreement (Annex 3) - FOR +/5. Confirmation of terms of agreement (Annex 3) - FOR 6. Personal career development plan and employment options after positive evaluation (Annex 4, as one file) - me with PEBA 7. List of reviewers (Annex 5) - me with consultation with institute +-> an Anke!! -8. Selection statistics (Annex 6) - FOR +/8. Selection statistics (Annex 6) - FOR -9. Data consent (Annex 7) - me with consultation with institute +/9. Data consent (Annex 7) - me with consultation with institute /- printed and signed + 10. University statement (Annex 8)- ??? later. 05 Juli diff --git a/Helmholtz/full_poposal/proposal_text/proposal.aux b/Helmholtz/full_poposal/proposal_text/proposal.aux index bf2f2ff..d7297c6 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.aux +++ b/Helmholtz/full_poposal/proposal_text/proposal.aux @@ -1,31 +1,49 @@ \relax \providecommand*\new@tpo@label[2]{} +\bibstyle{biblatex} +\bibdata{proposal-blx,references_new_main_used_since2023} +\citation{biblatex-control} +\abx@aux@refcontext{ydnt/global//global/global} \@writefile{toc}{\contentsline {section}{\numberline {1}Research Goals and Expected Outcomes?}{2}{}\protected@file@percent } \@writefile{toc}{\contentsline {section}{\numberline {2}Relation to Helmholtz Mission and Programme?}{3}{}\protected@file@percent } \@writefile{toc}{\contentsline {section}{\numberline {3}Relation to Research Programme of IBPT and KIT?}{3}{}\protected@file@percent } \@writefile{toc}{\contentsline {section}{\numberline {4}Current Status of Research?/State of the art and preliminary work?}{4}{}\protected@file@percent } \@writefile{toc}{\contentsline {subsection}{\numberline {4.1}State of the art: radiotherapy}{4}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {4.2}State of the art: accelerators and collective effects}{5}{}\protected@file@percent } \@writefile{lof}{\contentsline {figure}{\numberline {1}{\ignorespaces Sketch of the therapeutic window increasing as normal tissue complication probability (NTCP) is shifted to higher dose for FLASH RT and tumor control probability (TCP) remains.}}{5}{}\protected@file@percent } \newlabel{fig:therapeutic_window}{{1}{5}} +\@writefile{toc}{\contentsline {subsection}{\numberline {4.2}State of the art: accelerators and collective effects}{6}{}\protected@file@percent } +\citation{brosi_prab19} +\abx@aux@cite{0}{brosi_prab19} +\abx@aux@segm{0}{0}{brosi_prab19} \@writefile{toc}{\contentsline {subsection}{\numberline {4.3}Open questions and challenges? not here???}{7}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {4.4}Previous relevant work of Dr. Brosi?/Preliminary work on beam dynamics, collective effects and diagnostics}{7}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {4.4}Previous relevant work on beam dynamics, collective effects and diagnostics by Dr. Brosi}{7}{}\protected@file@percent } \@writefile{lof}{\contentsline {figure}{\numberline {2}{\ignorespaces Measurement (left) and simulation (right) of the longitudinal bunch profile on the vertical axis and the temporal evolution on the horizontal axis.}}{8}{}\protected@file@percent } \newlabel{fig:microwave_insta}{{2}{8}} -\@writefile{toc}{\contentsline {section}{\numberline {5}Work Packages?}{9}{}\protected@file@percent } -\@writefile{toc}{\contentsline {section}{\numberline {6}Work Plan?}{11}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {6.1}Time plan}{11}{}\protected@file@percent } -\@writefile{lof}{\contentsline {figure}{\numberline {3}{\ignorespaces Time plan showing the individual work packages colorcoded by responsible team member as well as the time frame of each team members within the project in the lower part.}}{11}{}\protected@file@percent } -\newlabel{fig:timeplan}{{3}{11}} +\@writefile{toc}{\contentsline {section}{\numberline {5}Work Packages?}{10}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {5.1}WP A}{10}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {5.2}WP B}{11}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {5.3}WP C}{11}{}\protected@file@percent } +\@writefile{toc}{\contentsline {section}{\numberline {6}Work Plan?}{12}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {6.1}Time plan}{12}{}\protected@file@percent } \@writefile{toc}{\contentsline {subsection}{\numberline {6.2}Group structure}{12}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {6.3}Scientific equipment}{13}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {6.4}Handling of research data/Research data plan}{13}{}\protected@file@percent } -\@writefile{toc}{\contentsline {subsection}{\numberline {6.5}Financial plan}{14}{}\protected@file@percent } -\@writefile{toc}{\contentsline {section}{\numberline {7}Cooperation and communication plan?}{16}{}\protected@file@percent } -\newlabel{LastPage}{{}{16}} -\xdef\lastpage@lastpage{16} +\@writefile{lof}{\contentsline {figure}{\numberline {3}{\ignorespaces Time plan showing the individual work packages color-coded by responsible team member as well as the time frame of each team members within the project in the lower part.}}{13}{}\protected@file@percent } +\newlabel{fig:timeplan}{{3}{13}} +\@writefile{toc}{\contentsline {subsection}{\numberline {6.3}Existing scientific equipment and infrastructure}{14}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {6.4}Handling of research data/Research data plan}{14}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsection}{\numberline {6.5}Financial plan}{16}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsubsection}{\numberline {6.5.1}Personnel costs}{16}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsubsection}{\numberline {6.5.2}Material costs}{17}{}\protected@file@percent } +\@writefile{toc}{\contentsline {subsubsection}{\numberline {6.5.3}Travel costs}{17}{}\protected@file@percent } +\@writefile{toc}{\contentsline {section}{\numberline {7}Cooperation and communication plan?}{18}{}\protected@file@percent } +\newlabel{LastPage}{{}{18}} +\xdef\lastpage@lastpage{18} \gdef\lastpage@lastpageHy{} +\abx@aux@number{1}{brosi_prab19}{0}{ydnt/global//global/global}{1} +\abx@aux@read@bbl@mdfivesum{B364B6A779DE34CCA5E21B4D6DFBE7A0} +\abx@aux@defaultrefcontext{0}{brosi_prab19}{ydnt/global//global/global} +\abx@aux@defaultlabelprefix{0}{brosi_prab19}{} \global\@namedef{scr@dte@section@lastmaxnumwidth}{9.55988pt} \global\@namedef{scr@dte@subsection@lastmaxnumwidth}{17.8997pt} +\global\@namedef{scr@dte@subsubsection@lastmaxnumwidth}{26.23953pt} \@writefile{toc}{\providecommand\tocbasic@end@toc@file{}\tocbasic@end@toc@file} -\gdef \@abspage@last{16} +\gdef \@abspage@last{18} diff --git a/Helmholtz/full_poposal/proposal_text/proposal.log b/Helmholtz/full_poposal/proposal_text/proposal.log index 9fee316..5e053da 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.log +++ b/Helmholtz/full_poposal/proposal_text/proposal.log @@ -1,4 +1,4 @@ -This is pdfTeX, Version 3.141592653-2.6-1.40.22 (TeX Live 2022/dev/Debian) (preloaded format=pdflatex 2024.3.20) 1 APR 2024 20:41 +This is pdfTeX, Version 3.141592653-2.6-1.40.22 (TeX Live 2022/dev/Debian) (preloaded format=pdflatex 2024.3.20) 9 APR 2024 21:01 entering extended mode restricted \write18 enabled. %&-line parsing enabled. @@ -260,44 +260,441 @@ Package: multirow 2021/03/15 v2.8 Span multiple rows of a table \multirow@dima=\skip76 \bigstrutjot=\dimen149 ) -LaTeX Font Info: Trying to load font information for OT1+phv on input line 2 -9. +(/usr/share/texlive/texmf-dist/tex/latex/tabularray/tabularray.sty +Package: tabularray 2021-12-01 v2021Q Typeset tabulars and arrays with LaTeX3 + +(/usr/share/texlive/texmf-dist/tex/latex/l3packages/xparse/xparse.sty +Package: xparse 2022-01-12 L3 Experimental document command parser +) +\l__tblr_a_int=\count268 +\l__tblr_c_int=\count269 +\l__tblr_r_int=\count270 +\l__tblr_d_dim=\dimen150 +\l__tblr_h_dim=\dimen151 +\l__tblr_o_dim=\dimen152 +\l__tblr_p_dim=\dimen153 +\l__tblr_q_dim=\dimen154 +\l__tblr_r_dim=\dimen155 +\l__tblr_s_dim=\dimen156 +\l__tblr_t_dim=\dimen157 +\l__tblr_v_dim=\dimen158 +\l__tblr_w_dim=\dimen159 +\l__tblr_a_box=\box53 +\l__tblr_b_box=\box54 +\l__tblr_c_box=\box55 +\l__tblr_d_box=\box56 +\g__tblr_table_count_int=\count271 +\c@rownum=\count272 +\c@colnum=\count273 +\c@rowcount=\count274 +\c@colcount=\count275 +\abovesep=\dimen160 +\belowsep=\dimen161 +\leftsep=\dimen162 +\rightsep=\dimen163 +\g_tblr_level_int=\count276 +\g__tblr_data_row_key_count_int=\count277 +\g__tblr_data_column_key_count_int=\count278 +\g__tblr_data_cell_key_count_int=\count279 +\g__tblr_array_int=\count280 +\l__tblr_key_count_int=\count281 +\l__tblr_key_quotient_int=\count282 +\l__tblr_key_quotient_two_int=\count283 +\l__tblr_key_remainder_int=\count284 +\g__tblr_data_str_value_count_int=\count285 +\rulewidth=\dimen164 +\l__multicolumn_cell_number_int=\count286 +\l__tblr_strut_ht_box=\box57 +\l__tblr_strut_dp_box=\box58 +\g__tblr_cell_wd_dim=\dimen165 +\g__tblr_cell_ht_dim=\dimen166 +\g__tblr_cell_head_dim=\dimen167 +\g__tblr_cell_foot_dim=\dimen168 +\l__column_target_dim=\dimen169 +\l__tblr_caption_box=\box59 +\l__tblr_caption_left_box=\box60 +\l__tblr_row_head_box=\box61 +\l__tblr_row_foot_box=\box62 +\l__tblr_row_head_foot_dim=\dimen170 +\tablewidth=\dimen171 +\l__tblr_table_firsthead_box=\box63 +\l__tblr_table_middlehead_box=\box64 +\l__tblr_table_lasthead_box=\box65 +\l__tblr_table_firstfoot_box=\box66 +\l__tblr_table_middlefoot_box=\box67 +\l__tblr_table_lastfoot_box=\box68 +\l__tblr_remain_height_dim=\dimen172 +\l__tblr_long_from_int=\count287 +\l__tblr_long_to_int=\count288 +\l__tblr_curr_i_int=\count289 +\l__tblr_prev_i_int=\count290 +\l__tblr_table_page_int=\count291 +\l__tblr_table_head_box=\box69 +\l__tblr_table_foot_box=\box70 +\l__tblr_table_head_foot_dim=\dimen173 +\l__tblr_table_head_body_foot_dim=\dimen174 +\l__tblr_table_box=\box71 +\l__tblr_table_hlines_box=\box72 +\l__tblr_hline_box=\box73 +\l__tblr_row_box=\box74 +\l__tblr_col_o_wd_dim=\dimen175 +\l__tblr_col_b_wd_dim=\dimen176 +\l__tblr_hline_leftskip_dim=\dimen177 +\l__tblr_hline_rightskip_dim=\dimen178 +\l__tblr_row_ht_dim=\dimen179 +\l__tblr_row_dp_dim=\dimen180 +\l__tblr_row_abovesep_dim=\dimen181 +\l__tblr_row_belowsep_dim=\dimen182 +\l__tblr_row_vlines_box=\box75 +\l__tblr_vline_box=\box76 +\l__tblr_cell_box=\box77 +\l__row_upper_dim=\dimen183 +\l__row_lower_dim=\dimen184 +\l__row_vpace_dim=\dimen185 +\l__tblr_vline_aboveskip_dim=\dimen186 +\l__tblr_vline_belowskip_dim=\dimen187 +\l__tblr_cell_wd_dim=\dimen188 +\l__tblr_cell_ht_dim=\dimen189 +\l__tblr_diag_box=\box78 +) +(/usr/share/texlive/texmf-dist/tex/latex/sectsty/sectsty.sty +Package: sectsty 2002/02/25 v2.0.2 Commands to change all sectional heading sty +les + + +LaTeX Warning: Command \underbar has changed. + Check if current package is valid. + + +LaTeX Warning: Command \underline has changed. + Check if current package is valid. + +) + +Class scrartcl Warning: Incompatible package `sectsty' loaded! +(scrartcl) Package `sectsty' up to version 2.0.2 is incompatible +(scrartcl) with KOMA-Script from version 2.8e released in 2001. +(scrartcl) You should avoid that package and configure the +(scrartcl) section titles of your document using the KOMA-Script +(scrartcl) user interface, e.g., \chapterlinesformat, +(scrartcl) \RedeclareSectionCommand etc. or you should ask +(scrartcl) the `sectsty' maintainer for a more compatible release. + +(scrartcl) Ignoring this warning could result in several error +(scrartcl) messages and formatting issues after loading package +(scrartcl) `sectsty' on input line 20. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/biblatex.sty +Package: biblatex 2022/02/02 v3.17 programmable bibliographies (PK/MW) + +(/usr/share/texlive/texmf-dist/tex/generic/pdftexcmds/pdftexcmds.sty +Package: pdftexcmds 2020-06-27 v0.33 Utility functions of pdfTeX for LuaTeX (HO +) + +(/usr/share/texlive/texmf-dist/tex/generic/infwarerr/infwarerr.sty +Package: infwarerr 2019/12/03 v1.5 Providing info/warning/error messages (HO) +) +(/usr/share/texlive/texmf-dist/tex/generic/ltxcmds/ltxcmds.sty +Package: ltxcmds 2020-05-10 v1.25 LaTeX kernel commands for general use (HO) +) +Package pdftexcmds Info: \pdf@primitive is available. +Package pdftexcmds Info: \pdf@ifprimitive is available. +Package pdftexcmds Info: \pdfdraftmode found. +) +(/usr/share/texlive/texmf-dist/tex/latex/etoolbox/etoolbox.sty +Package: etoolbox 2020/10/05 v2.5k e-TeX tools for LaTeX (JAW) +\etb@tempcnta=\count292 +) +(/usr/share/texlive/texmf-dist/tex/latex/kvoptions/kvoptions.sty +Package: kvoptions 2020-10-07 v3.14 Key value format for package options (HO) + +(/usr/share/texlive/texmf-dist/tex/generic/kvsetkeys/kvsetkeys.sty +Package: kvsetkeys 2019/12/15 v1.18 Key value parser (HO) +)) +(/usr/share/texlive/texmf-dist/tex/latex/logreq/logreq.sty +Package: logreq 2010/08/04 v1.0 xml request logger +\lrq@indent=\count293 + +(/usr/share/texlive/texmf-dist/tex/latex/logreq/logreq.def +File: logreq.def 2010/08/04 v1.0 logreq spec v1.0 +)) +(/usr/share/texlive/texmf-dist/tex/latex/base/ifthen.sty +Package: ifthen 2020/11/24 v1.1c Standard LaTeX ifthen package (DPC) +) +(/usr/share/texlive/texmf-dist/tex/latex/url/url.sty +\Urlmuskip=\muskip16 +Package: url 2013/09/16 ver 3.4 Verb mode for urls, etc. +) +\c@tabx@nest=\count294 +\c@listtotal=\count295 +\c@listcount=\count296 +\c@liststart=\count297 +\c@liststop=\count298 +\c@citecount=\count299 +\c@citetotal=\count300 +\c@multicitecount=\count301 +\c@multicitetotal=\count302 +\c@instcount=\count303 +\c@maxnames=\count304 +\c@minnames=\count305 +\c@maxitems=\count306 +\c@minitems=\count307 +\c@citecounter=\count308 +\c@maxcitecounter=\count309 +\c@savedcitecounter=\count310 +\c@uniquelist=\count311 +\c@uniquename=\count312 +\c@refsection=\count313 +\c@refsegment=\count314 +\c@maxextratitle=\count315 +\c@maxextratitleyear=\count316 +\c@maxextraname=\count317 +\c@maxextradate=\count318 +\c@maxextraalpha=\count319 +\c@abbrvpenalty=\count320 +\c@highnamepenalty=\count321 +\c@lownamepenalty=\count322 +\c@maxparens=\count323 +\c@parenlevel=\count324 +\blx@tempcnta=\count325 +\blx@tempcntb=\count326 +\blx@tempcntc=\count327 +\c@blx@maxsection=\count328 +\c@blx@maxsegment@0=\count329 +\blx@notetype=\count330 +\blx@parenlevel@text=\count331 +\blx@parenlevel@foot=\count332 +\c@blx@sectionciteorder@0=\count333 +\blx@entrysetcounter=\count334 +\blx@biblioinstance=\count335 +\labelnumberwidth=\skip77 +\labelalphawidth=\skip78 +\biblabelsep=\skip79 +\bibitemsep=\skip80 +\bibnamesep=\skip81 +\bibinitsep=\skip82 +\bibparsep=\skip83 +\bibhang=\skip84 +\blx@bcfin=\read2 +\blx@bcfout=\write3 +\blx@langwohyphens=\language87 +\c@mincomprange=\count336 +\c@maxcomprange=\count337 +\c@mincompwidth=\count338 +Package biblatex Info: Trying to load biblatex default data model... +Package biblatex Info: ... file 'blx-dm.def' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/blx-dm.def +File: blx-dm.def 2022/02/02 v3.17 biblatex localization (PK/MW) +) +Package biblatex Info: Trying to load biblatex custom data model... +Package biblatex Info: ... file 'biblatex-dm.cfg' not found. +\c@afterword=\count339 +\c@savedafterword=\count340 +\c@annotator=\count341 +\c@savedannotator=\count342 +\c@author=\count343 +\c@savedauthor=\count344 +\c@bookauthor=\count345 +\c@savedbookauthor=\count346 +\c@commentator=\count347 +\c@savedcommentator=\count348 +\c@editor=\count349 +\c@savededitor=\count350 +\c@editora=\count351 +\c@savededitora=\count352 +\c@editorb=\count353 +\c@savededitorb=\count354 +\c@editorc=\count355 +\c@savededitorc=\count356 +\c@foreword=\count357 +\c@savedforeword=\count358 +\c@holder=\count359 +\c@savedholder=\count360 +\c@introduction=\count361 +\c@savedintroduction=\count362 +\c@namea=\count363 +\c@savednamea=\count364 +\c@nameb=\count365 +\c@savednameb=\count366 +\c@namec=\count367 +\c@savednamec=\count368 +\c@translator=\count369 +\c@savedtranslator=\count370 +\c@shortauthor=\count371 +\c@savedshortauthor=\count372 +\c@shorteditor=\count373 +\c@savedshorteditor=\count374 +\c@labelname=\count375 +\c@savedlabelname=\count376 +\c@institution=\count377 +\c@savedinstitution=\count378 +\c@lista=\count379 +\c@savedlista=\count380 +\c@listb=\count381 +\c@savedlistb=\count382 +\c@listc=\count383 +\c@savedlistc=\count384 +\c@listd=\count385 +\c@savedlistd=\count386 +\c@liste=\count387 +\c@savedliste=\count388 +\c@listf=\count389 +\c@savedlistf=\count390 +\c@location=\count391 +\c@savedlocation=\count392 +\c@organization=\count393 +\c@savedorganization=\count394 +\c@origlocation=\count395 +\c@savedoriglocation=\count396 +\c@origpublisher=\count397 +\c@savedorigpublisher=\count398 +\c@publisher=\count399 +\c@savedpublisher=\count400 +\c@language=\count401 +\c@savedlanguage=\count402 +\c@origlanguage=\count403 +\c@savedoriglanguage=\count404 +\c@pageref=\count405 +\c@savedpageref=\count406 +\shorthandwidth=\skip85 +\shortjournalwidth=\skip86 +\shortserieswidth=\skip87 +\shorttitlewidth=\skip88 +\shortauthorwidth=\skip89 +\shorteditorwidth=\skip90 +\locallabelnumberwidth=\skip91 +\locallabelalphawidth=\skip92 +\localshorthandwidth=\skip93 +\localshortjournalwidth=\skip94 +\localshortserieswidth=\skip95 +\localshorttitlewidth=\skip96 +\localshortauthorwidth=\skip97 +\localshorteditorwidth=\skip98 +Package biblatex Info: Trying to load compatibility code... +Package biblatex Info: ... file 'blx-compat.def' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/blx-compat.def +File: blx-compat.def 2022/02/02 v3.17 biblatex compatibility (PK/MW) +) +Package biblatex Info: Trying to load BibTeX backend compatibility... +Package biblatex Info: ... file 'blx-bibtex.def' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/blx-bibtex.def +File: blx-bibtex.def 2022/02/02 v3.17 biblatex compatibility (PK/MW) + + +Package biblatex Warning: Using fall-back BibTeX(8) backend: +(biblatex) functionality may be reduced/unavailable. + +) +Package biblatex Info: Trying to load generic definitions... +Package biblatex Info: ... file 'biblatex.def' found. + (/usr/share/texlive/texmf-dist/tex/latex/biblatex/biblatex.def +File: biblatex.def 2022/02/02 v3.17 biblatex compatibility (PK/MW) +\c@textcitecount=\count407 +\c@textcitetotal=\count408 +\c@textcitemaxnames=\count409 +\c@biburlbigbreakpenalty=\count410 +\c@biburlbreakpenalty=\count411 +\c@biburlnumpenalty=\count412 +\c@biburlucpenalty=\count413 +\c@biburllcpenalty=\count414 +\biburlbigskip=\muskip17 +\biburlnumskip=\muskip18 +\biburlucskip=\muskip19 +\biburllcskip=\muskip20 +\c@smartand=\count415 +) +Package biblatex Info: Trying to load bibliography style 'numeric'... +Package biblatex Info: ... file 'numeric.bbx' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/bbx/numeric.bbx +File: numeric.bbx 2022/02/02 v3.17 biblatex bibliography style (PK/MW) +Package biblatex Info: Trying to load bibliography style 'standard'... +Package biblatex Info: ... file 'standard.bbx' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/bbx/standard.bbx +File: standard.bbx 2022/02/02 v3.17 biblatex bibliography style (PK/MW) +\c@bbx:relatedcount=\count416 +\c@bbx:relatedtotal=\count417 +)) +Package biblatex Info: Trying to load citation style 'numeric'... +Package biblatex Info: ... file 'numeric.cbx' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/cbx/numeric.cbx +File: numeric.cbx 2022/02/02 v3.17 biblatex citation style (PK/MW) +Package biblatex Info: Redefining '\cite'. +Package biblatex Info: Redefining '\parencite'. +Package biblatex Info: Redefining '\footcite'. +Package biblatex Info: Redefining '\footcitetext'. +Package biblatex Info: Redefining '\smartcite'. +Package biblatex Info: Redefining '\supercite'. +Package biblatex Info: Redefining '\textcite'. +Package biblatex Info: Redefining '\textcites'. +Package biblatex Info: Redefining '\cites'. +Package biblatex Info: Redefining '\parencites'. +Package biblatex Info: Redefining '\smartcites'. +) +Package biblatex Info: Trying to load configuration file... +Package biblatex Info: ... file 'biblatex.cfg' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/biblatex.cfg +File: biblatex.cfg +) + +Package biblatex Warning: 'firstinits' option is deprecated. +(biblatex) Please use 'giveninits' instead. + +Package biblatex Info: Input encoding 'utf8' detected. +Package biblatex Info: Document encoding is UTF8 .... +Package biblatex Info: ... and expl3 +(biblatex) 2022-01-21 L3 programming layer (loader) +(biblatex) is new enough (at least 2020/04/06), +(biblatex) setting 'casechanger=expl3'. +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/blx-case-expl3.sty +Package: blx-case-expl3 2022/02/02 v3.17 expl3 case changing code for biblatex +)) +\@quotelevel=\count418 +\@quotereset=\count419 +LaTeX Font Info: Trying to load font information for OT1+phv on input line 7 +4. (/usr/share/texlive/texmf-dist/tex/latex/psnfss/ot1phv.fd File: ot1phv.fd 2020/03/25 scalable font definitions for OT1/phv. ) (./proposal.aux) \openout1 = `proposal.aux'. -LaTeX Font Info: Checking defaults for OML/cmm/m/it on input line 29. -LaTeX Font Info: ... okay on input line 29. -LaTeX Font Info: Checking defaults for OMS/cmsy/m/n on input line 29. -LaTeX Font Info: ... okay on input line 29. -LaTeX Font Info: Checking defaults for OT1/cmr/m/n on input line 29. -LaTeX Font Info: ... okay on input line 29. -LaTeX Font Info: Checking defaults for T1/cmr/m/n on input line 29. -LaTeX Font Info: ... okay on input line 29. -LaTeX Font Info: Checking defaults for TS1/cmr/m/n on input line 29. -LaTeX Font Info: ... okay on input line 29. -LaTeX Font Info: Checking defaults for OMX/cmex/m/n on input line 29. -LaTeX Font Info: ... okay on input line 29. -LaTeX Font Info: Checking defaults for U/cmr/m/n on input line 29. -LaTeX Font Info: ... okay on input line 29. -Package scrbase Info: activating english \contentsname on input line 29. -Package scrbase Info: activating english \listfigurename on input line 29. -Package scrbase Info: activating english \listtablename on input line 29. +LaTeX Font Info: Checking defaults for OML/cmm/m/it on input line 74. +LaTeX Font Info: ... okay on input line 74. +LaTeX Font Info: Checking defaults for OMS/cmsy/m/n on input line 74. +LaTeX Font Info: ... okay on input line 74. +LaTeX Font Info: Checking defaults for OT1/cmr/m/n on input line 74. +LaTeX Font Info: ... okay on input line 74. +LaTeX Font Info: Checking defaults for T1/cmr/m/n on input line 74. +LaTeX Font Info: ... okay on input line 74. +LaTeX Font Info: Checking defaults for TS1/cmr/m/n on input line 74. +LaTeX Font Info: ... okay on input line 74. +LaTeX Font Info: Checking defaults for OMX/cmex/m/n on input line 74. +LaTeX Font Info: ... okay on input line 74. +LaTeX Font Info: Checking defaults for U/cmr/m/n on input line 74. +LaTeX Font Info: ... okay on input line 74. +Package scrbase Info: activating english \contentsname on input line 74. +Package scrbase Info: activating english \listfigurename on input line 74. +Package scrbase Info: activating english \listtablename on input line 74. (/usr/share/texlive/texmf-dist/tex/context/base/mkii/supp-pdf.mkii [Loading MPS to PDF converter (version 2006.09.02).] -\scratchcounter=\count268 -\scratchdimen=\dimen150 -\scratchbox=\box53 -\nofMPsegments=\count269 -\nofMParguments=\count270 +\scratchcounter=\count420 +\scratchdimen=\dimen190 +\scratchbox=\box79 +\nofMPsegments=\count421 +\nofMParguments=\count422 \everyMPshowfont=\toks18 -\MPscratchCnt=\count271 -\MPscratchDim=\dimen151 -\MPnumerator=\count272 -\makeMPintoPDFobject=\count273 +\MPscratchCnt=\count423 +\MPscratchDim=\dimen191 +\MPnumerator=\count424 +\makeMPintoPDFobject=\count425 \everyMPtoPDFconversion=\toks19 ) (/usr/share/texlive/texmf-dist/tex/latex/epstopdf-pkg/epstopdf-base.sty Package: epstopdf-base 2020-01-24 v2.11 Base part for package epstopdf @@ -310,7 +707,7 @@ e )) Package lastpage Info: Please have a look at the pageslts package at (lastpage) https://www.ctan.org/pkg/pageslts -(lastpage) ! on input line 29. +(lastpage) ! on input line 74. *geometry* driver: auto-detecting *geometry* detected driver: pdftex @@ -346,6 +743,52 @@ Package lastpage Info: Please have a look at the pageslts package at * \@reversemarginfalse * (1in=72.27pt=25.4mm, 1cm=28.453pt) +(/usr/share/texlive/texmf-dist/tex/latex/ninecolors/ninecolors.sty +Package: ninecolors 2021/05/24 v2021C Select colors with proper color contrast +) +Package biblatex Info: Trying to load language 'english'... +Package biblatex Info: ... file 'english.lbx' found. + +(/usr/share/texlive/texmf-dist/tex/latex/biblatex/lbx/english.lbx +File: english.lbx 2022/02/02 v3.17 biblatex localization (PK/MW) +) +Package biblatex Info: Input encoding 'utf8' detected. +Package biblatex Info: Automatic encoding selection. +(biblatex) Assuming data encoding 'utf8'. +Package biblatex Info: Input encoding 'utf8' detected. +Package biblatex Info: Data encoding 'utf8' specified. +(biblatex) No need to reencode data. +\openout3 = `proposal-blx.bib'. + +Package biblatex Info: Trying to load bibliographic data... +Package biblatex Info: ... file 'proposal.bbl' found. + +(./proposal.bbl + +Package biblatex Warning: BibTeX reported the following issues +(biblatex) with 'brosi_prab19': +(biblatex) - Invalid format of field 'month'. + +) +Package biblatex Info: Reference section=0 on input line 74. +Package biblatex Info: Reference segment=0 on input line 74. + + +Class scrartcl Warning: Incompatible usage of \@ssect detected. +(scrartcl) You've used the KOMA-Script implementation of \@ssect +(scrartcl) from within a non compatible caller, that does not +(scrartcl) \scr@s@ct@@nn@m@ locally. +(scrartcl) This could result in several error messages on input li +ne 90. + + +Class scrartcl Warning: Incompatible usage of \@ssect detected. +(scrartcl) You've used the KOMA-Script implementation of \@ssect +(scrartcl) from within a non compatible caller, that does not +(scrartcl) \scr@s@ct@@nn@m@ locally. +(scrartcl) This could result in several error messages on input li +ne 98. + (./proposal.toc LaTeX Font Info: External font `cmex10' loaded for size (Font) <7> on input line 5. @@ -363,11 +806,11 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): [1{/var/lib/texmf/fonts/map/pdftex/updmap/pdftex.map} ]) -\tf@toc=\write3 -\openout3 = `proposal.toc'. +\tf@toc=\write4 +\openout4 = `proposal.toc'. -Underfull \hbox (badness 10000) in paragraph at lines 63--68 +Underfull \hbox (badness 10000) in paragraph at lines 108--113 [] @@ -392,7 +835,7 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): File: plots/bild_xkcd_darker2.png Graphic file (type png) -Package pdftex.def Info: plots/bild_xkcd_darker2.png used on input line 93. +Package pdftex.def Info: plots/bild_xkcd_darker2.png used on input line 151. (pdftex.def) Requested size: 295.90588pt x 159.60149pt. @@ -423,15 +866,21 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): [6] LaTeX Font Info: Trying to load font information for TS1+phv on input line 1 -21. +79. (/usr/share/texlive/texmf-dist/tex/latex/psnfss/ts1phv.fd File: ts1phv.fd 2020/03/25 scalable font definitions for TS1/phv. ) - +LaTeX Font Info: External font `cmex10' loaded for size +(Font) <8> on input line 189. +LaTeX Font Info: External font `cmex10' loaded for size +(Font) <6> on input line 189. +LaTeX Font Info: Font shape `OT1/phv/m/it' in size <8> not available +(Font) Font shape `OT1/phv/m/sl' tried instead on input line 189. + File: plots/micro-wave_mes_vs_simulation.png Graphic file (type png) Package pdftex.def Info: plots/micro-wave_mes_vs_simulation.png used on input -line 136. +line 194. (pdftex.def) Requested size: 432.48051pt x 99.11406pt. @@ -443,34 +892,6 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. [7] -Overfull \vbox (12.0pt too high) detected at line 162 - [] - - -Underfull \hbox (badness 3954) in paragraph at lines 165--165 -[]\OT1/phv/b/n/10 A2.2 \OT1/phv/m/n/10 Sim-u-la-tion with ex-ist-ing mod-els fo -r - [] - - -Underfull \hbox (badness 2538) in paragraph at lines 171--171 -[]\OT1/phv/b/n/10 B2.1 \OT1/phv/m/n/10 Exp. test de-pen-dence of dif-fer-ent - [] - - -Overfull \vbox (12.0pt too high) detected at line 182 - [] - - -Underfull \hbox (badness 6141) in paragraph at lines 183--183 -[]\OT1/phv/b/n/10 C4.2 \OT1/phv/m/n/10 Tests of gen-er-at-ing cus-tom (user- - [] - - -Overfull \hbox (1.6996pt too wide) in paragraph at lines 152--186 - [] - [] - Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) Make it at least 28.66049pt, for example: @@ -481,6 +902,45 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): [8 <./plots/micro-wave_mes_vs_simulation.png (PNG copy)>] +Class scrartcl Warning: Incompatible usage of \@ssect detected. +(scrartcl) You've used the KOMA-Script implementation of \@ssect +(scrartcl) from within a non compatible caller, that does not +(scrartcl) \scr@s@ct@@nn@m@ locally. +(scrartcl) This could result in several error messages on input li +ne 208. + +LaTeX Font Info: Font shape `OT1/phv/m/it' in size <10> not available +(Font) Font shape `OT1/phv/m/sl' tried instead on input line 208. + +Overfull \vbox (12.0pt too high) detected at line 222 + [] + + +Underfull \hbox (badness 3954) in paragraph at lines 225--225 +[]\OT1/phv/b/n/10 A2.2 \OT1/phv/m/n/10 Sim-u-la-tion with ex-ist-ing mod-els fo +r + [] + + +Underfull \hbox (badness 2538) in paragraph at lines 231--231 +[]\OT1/phv/b/n/10 B2.1 \OT1/phv/m/n/10 Exp. test de-pen-dence of dif-fer-ent + [] + + +Overfull \vbox (12.0pt too high) detected at line 242 + [] + + +Underfull \hbox (badness 6141) in paragraph at lines 243--243 +[]\OT1/phv/b/n/10 C4.2 \OT1/phv/m/n/10 Tests of gen-er-at-ing cus-tom (user- + [] + + +Overfull \hbox (1.6996pt too wide) in paragraph at lines 212--246 + [] + [] + + Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) Make it at least 28.66049pt, for example: (fancyhdr) \setlength{\headheight}{28.66049pt}. @@ -498,12 +958,6 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. [10] - -File: plots/gantt_HH.pdf Graphic file (type pdf) - -Package pdftex.def Info: plots/gantt_HH.pdf used on input line 201. -(pdftex.def) Requested size: 455.24411pt x 339.1766pt. - Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) Make it at least 28.66049pt, for example: @@ -512,25 +966,15 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. -[11 <./plots/gantt_HH.pdf>] -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 237. -LaTeX Font Info: Trying to load font information for TS1+cmss on input line -237. +[11] + +File: plots/gantt_HH.pdf Graphic file (type pdf) + +Package pdftex.def Info: plots/gantt_HH.pdf used on input line 271. +(pdftex.def) Requested size: 455.24411pt x 339.1766pt. -(/usr/share/texlive/texmf-dist/tex/latex/base/ts1cmss.fd -File: ts1cmss.fd 2019/12/16 v2.5j Standard LaTeX font definitions -) -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 238. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 239. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 240. + +LaTeX Warning: `!h' float specifier changed to `!ht'. Package fancyhdr Warning: \headheight is too small (28.45274pt): @@ -541,31 +985,6 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. [12] -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 243. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 244. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 247. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 248. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 249. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 252. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 253. -LaTeX Info: Symbol \textopenbullet not provided by - font family phv in TS1 encoding. - Default family used instead on input line 254. - Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) Make it at least 28.66049pt, for example: @@ -574,7 +993,12 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. -[13] +[13 <./plots/gantt_HH.pdf>] +Overfull \hbox (1.74353pt too wide) in paragraph at lines 322--323 +[]\OT1/phv/m/n/10 Extensive ac-cel-er-a-tor di-ag-nos-tic for beam char-ac-ter- +i-za-tion, in-clud-ing beam and bunch charge, + [] + Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) Make it at least 28.66049pt, for example: @@ -592,7 +1016,25 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. -[15] +[15] + +Package fancyhdr Warning: \headheight is too small (28.45274pt): +(fancyhdr) Make it at least 28.66049pt, for example: +(fancyhdr) \setlength{\headheight}{28.66049pt}. +(fancyhdr) You might also make \topmargin smaller to compensate: + +(fancyhdr) \addtolength{\topmargin}{-0.20775pt}. + +[16] + +Package fancyhdr Warning: \headheight is too small (28.45274pt): +(fancyhdr) Make it at least 28.66049pt, for example: +(fancyhdr) \setlength{\headheight}{28.66049pt}. +(fancyhdr) You might also make \topmargin smaller to compensate: + +(fancyhdr) \addtolength{\topmargin}{-0.20775pt}. + +[17] AED: lastpage setting LastPage Package fancyhdr Warning: \headheight is too small (28.45274pt): @@ -602,34 +1044,40 @@ Package fancyhdr Warning: \headheight is too small (28.45274pt): (fancyhdr) \addtolength{\topmargin}{-0.20775pt}. -[16] (./proposal.aux) ) +[18] (./proposal.aux) +Package logreq Info: Writing requests to 'proposal.run.xml'. +\openout1 = `proposal.run.xml'. + + ) (\end occurred inside a group at level 1) -### simple group (level 1) entered at line 153 ({) +### simple group (level 1) entered at line 213 ({) ### bottom level Here is how much of TeX's memory you used: - 6183 strings out of 478287 - 127023 string characters out of 5849289 - 656986 words of memory out of 5000000 - 24327 multiletter control sequences out of 15000+600000 - 480732 words of font info for 44 fonts, out of 8000000 for 9000 + 16175 strings out of 478287 + 333368 string characters out of 5849289 + 1079162 words of memory out of 5000000 + 34210 multiletter control sequences out of 15000+600000 + 494983 words of font info for 65 fonts, out of 8000000 for 9000 1141 hyphenation exceptions out of 8191 - 108i,13n,106p,10603b,323s stack positions out of 5000i,500n,10000p,200000b,80000s -{/usr/share/texmf/fonts/enc/dvips/cm-super/cm-super-ts1.enc}{/u -sr/share/texlive/texmf-dist/fonts/enc/dvips/base/8r.enc} -Output written on proposal.pdf (16 pages, 832919 bytes). +s/cm/cmsy7.pfb> +Output written on proposal.pdf (18 pages, 856510 bytes). PDF statistics: - 142 PDF objects out of 1000 (max. 8388607) - 82 compressed objects within 1 object stream + 158 PDF objects out of 1000 (max. 8388607) + 92 compressed objects within 1 object stream 0 named destinations out of 1000 (max. 500000) 34 words of extra memory for PDF output out of 10000 (max. 10000000) diff --git a/Helmholtz/full_poposal/proposal_text/proposal.pdf b/Helmholtz/full_poposal/proposal_text/proposal.pdf index ca642df..31c1089 100644 Binary files a/Helmholtz/full_poposal/proposal_text/proposal.pdf and b/Helmholtz/full_poposal/proposal_text/proposal.pdf differ diff --git a/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz b/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz index 13f6a74..8de1a49 100644 Binary files a/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz and b/Helmholtz/full_poposal/proposal_text/proposal.synctex.gz differ diff --git a/Helmholtz/full_poposal/proposal_text/proposal.tex b/Helmholtz/full_poposal/proposal_text/proposal.tex index 7f8599d..49f5bc3 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.tex +++ b/Helmholtz/full_poposal/proposal_text/proposal.tex @@ -12,8 +12,15 @@ \usepackage[top=2.5cm,bottom=2.5cm,left=2.5cm,right=2.5cm,footskip=1.5cm,headsep=0.8cm,headheight=1cm]{geometry} \usepackage{graphicx}% Include figure files \usepackage{multirow} +\usepackage{tabularray} % \linespread{1.1} +\definecolor{HH}{HTML}{2e74b5} +\usepackage{sectsty} +\sectionfont{\color{HH}} +\subsectionfont{\color{HH}} + + % \usepackage{scrpage2} \renewcommand{\headruleskip}{0.2cm} \renewcommand{\footruleskip}{0.5cm} @@ -23,6 +30,44 @@ \setlength{\parindent}{0em} \setlength{\parskip}{0.85ex} + +%\usepackage[backend=bibtex,style=verbose-trad2]{biblatex} +\usepackage[backend=bibtex,firstinits=true,sorting=ydnt,maxnames=40,defernumbers=true,isbn=false]{biblatex} %style=verbose + +\bibliography{references_new_main_used_since2023} +% \bibliography{my_publications_until2024_ExportedItems_zotero.bib} + +\renewbibmacro*{doi+eprint+url}{% +\iftoggle{bbx:url} +{\iffieldundef{doi}{\usebibmacro{url+urldate}}{}} +{}% +\newunit\newblock +\iftoggle{bbx:eprint} {\usebibmacro{eprint}} +{}% +\newunit\newblock +\iftoggle{bbx:doi} +{\printfield{doi}} {}} + + +%\defbibcheck{old}{ +% \ifnumless{\thefield{year}}{2015} +% {\skipentry} +% {} +%} +% +%\defbibcheck{old2}{ +% \ifnumless{\thefield{year}}{2015} +% {\skipentry} +% {} +%} + +\defbibfilter{conferenceproceedings}{ + ( type=article and keyword=light-review ) + or type=inproceedings +} + +\renewcommand{\cite}[1]{\footfullcite{#1}} + \author{Dr. Miriam Brosi} \title{Beam Dynamics and Collective Effects in the Generation and Propagation of Structured Beams for Advanced Accelerator-based Radiotherapy} @@ -69,6 +114,19 @@ The following four objectives are selected:\\ These objectives will be achieved by investigating the influence of collective effects on the beam generation, beam transport, beam-matter interaction and diagnostics in novel electron radiotherapy methods with temporally and spatially structured beams. Therefore, different interactions of beam particles with one another, described as collective effects, will be considered and incorporated into theoretical calculations and simulations of the transport of the particle beam from start-to-end, not only within the accelerator but also extended to the transport through matter (e.g., air or water) (objective I.). Furthermore, systematic studies on the dependence of different detection mechanisms and diagnostic tools on temporal and spatial pulse shapes combined with varying intensity will give insight into which diagnostic tools are suitable to aid in reliably delivering the desired conditions (objective II.). The investigation on the possibility to modulate the beam in the accelerator will pursue and compare different methods which will provide different temporal and spacial modulations. It will also entail studies on which modulations can be achieved on the final target when taking the transport through matter into consideration (objective III.). Employing the improved and extended simulation (from the first objective) to predict the resulting distribution on the target, might allow to consider the effects of the beam transport already during the generation of the beam. And if successful, this could enable the generation of a temporal and spatial particle distribution which preemptively compensates for the deformation expected during the propagation of the particle distribution from generation to the target. As a result, it would become possible to generate (within certain parameter limits) user-definable final particle distributions on the target (objective IV.). \section{Relation to Helmholtz Mission and Programme?} +... + + +The proposed research project agrees very well with the core objectives of the Helmholtz program Matter and Technology (MT) with the topic Accelerator Research and Development (ARD) covering the dynamics, detection and control of short-pulsed accelerator beams with custom properties. +These topics fall precisely in the research activities at the Institute for Beam Physics and Technology (IBPT), home to the KIT electron accelerators. +The strong ties to the MT topic Detector Technologies and Systems (DTS) with the in-house partner at KIT, the Institute for Data Processing and Electronics (IPE), will be a valuable asset for the project. +Moreover, the project is perfectly in line with the ideas of the recently established KIT-center Health Technologies, strengthening the important component of accelerator research with respect to radiotherapy. + +... + + + + \section{Relation to Research Programme of IBPT and KIT?} 2.6 Justification for the choice of host institution(s) @@ -98,7 +156,7 @@ allows a higher dose per fraction than in conventional radiotherapy without caus The high dose rates result in difficulties with standard dosimetry techniques showing deviations from the required linear detection efficiency [5]. So is, for example, the Fricke dosimetry nearly independent of does rate up to approximately 2 Gy per pulse, which is exceeded under FLASH conditions. Therefore, the primary standard for dosimetry in conventional electron RT is not applicable to FLASH RT. To this end, the effects leading to the observed deviations between expected and detected dose are under investigation and new dosimetry calibration procedures and detectors are being tested [6]. Recent work has, for example, included further investigations of ion-recombination in ionization chambers including improved ways of calculating the recombination correction factors [7]. In addition, systematic tests of possible, alternative detection mechanisms such as solid-state calorimeters and small-volume and active dosimeters were conducted [5], [8]. Active detectors and real-time diagnostics become increasingly relevant as well for beam monitoring as each of the few high dose pulses carries a non-negligible amount of the total dose described for treatment, increasing the required per shot accuracy as fluctuations in dose per pulse no longer average out. Besides the obvious need to establish accurate dosimetry methods, the prediction of the expected dose on target can be improved by including collective effects into the simulations. This will be described further in the state of the art: accelerators and collective effects section. For most standard medical accelerators the FLASH conditions are challenging if not impossible to achieve, requiring substantial improvement or the development of dedicated FLASH accelerators [9]. In the meantime, dedicated accelerator facilities with compatible beam conditions are employed as test-beds. -Another possibility to achieve reduced normal tissue damage are spatially structured beams used in \textbf{Microbeam Radiotherapy (MRT)} [10]. The spatial intensity modulation at the micrometer scale has shown the potential to widen the therapeutic window. The underlying biological mechanisms are suspected to have significant overlap with the mechanisms behind the FLASH effect due to the similarly high dose and dose rates in the micron-sized individual beamlets in the array of parallel microbeams [10]. Earlier studies with electron GRID radiotherapy [11] and recent studies with protons showed promising results in the sparing of healthy tissue [12]. Nevertheless, most studies on MRT have been conducted with X-rays. The unidirectional microbeams with spot sizes of 25 - 100 $\textrm{\textmu m}$ and a spot spacing of 50 - 200 $\textrm{\textmu m}$ are produced by inserting a multi-slit collimator into an x-ray beam with very small divergence produced at a 3rd generation light source [13]. This dependence on large infrastructure synchrotron sources is one of the main challenges in MRT today. With most research focusing on the modulation of the beam outside the accelerator close to the target area, accelerator-based electron beam modulation remains an open research question. +Another possibility to achieve reduced normal tissue damage are spatially structured beams used in \mbox{\textbf{Microbeam Radiotherapy (MRT)} [10]}. The spatial intensity modulation at the micrometer scale has shown the potential to widen the therapeutic window. The underlying biological mechanisms are suspected to have significant overlap with the mechanisms behind the FLASH effect due to the similarly high dose and dose rates in the micron-sized individual beamlets in the array of parallel microbeams [10]. Earlier studies with electron GRID radiotherapy [11] and recent studies with protons showed promising results in the sparing of healthy tissue [12]. Nevertheless, most studies on MRT have been conducted with X-rays. The unidirectional microbeams with spot sizes of 25 - 100 $\textrm{\textmu m}$ and a spot spacing of 50 - 200 $\textrm{\textmu m}$ are produced by inserting a multi-slit collimator into an x-ray beam with very small divergence produced at a 3rd generation light source [13]. This dependence on large infrastructure synchrotron sources is one of the main challenges in MRT today. With most research focusing on the modulation of the beam outside the accelerator close to the target area, accelerator-based electron beam modulation remains an open research question. In summary, it can be concluded, that the high temporal or spatial structuring for both novel radiotherapy methods, FLASH RT and Microbeam RT, leads to an increased complexity in the diagnostics of the beam properties and the dose as well as in the generation. In addition to the capability to generate and diagnose beams for FLASH RT, also the beam dynamics under the extreme beam properties need to be investigated in great detail to understand and simulate the resulting effect on the beam properties on target. @@ -125,10 +183,10 @@ Some of the aforementioned most pressing questions and challenges for accelerato \item The production of structured beams for Microbeam RT poses a challenge. \end{itemize} -In general, a sound understanding of the effects involved in the dynamics of temporally and spatially structured RT beams is required for the generation, the propagation as well as the detection of the resulting high dose-rate pulses. Identifying the contributing collective effects and shedding more light onto their deforming influence is therefore crucial to accurately predict the particle, and therefore, dose distribution on target. +In general, a sound understanding of the effects involved in the dynamics of temporally and spatially structured RT beams is required for the generation, the propagation as well as the detection of the resulting high dose-rate pulses. Identifying the contributing collective effects and shedding more light onto their deforming influence is therefore crucial to accurately predict the particle-, and therefore, dose-distribution on target. -\subsection{Previous relevant work of Dr. Brosi?/Preliminary work on beam dynamics, collective effects and diagnostics} -In the last years, I have performed systematic studies of the longitudinal as well as transverse collective effects and instabilities influencing the bunch shape in all dimensions. The main goal was to investigate phenomena occurring under extreme operation modes to understand and circumvent resulting performance limitations while contributing to the general advancement of the field. The studied conditions included high charge in single bunches, dedicated short bunch-length operation modes at the storage ring KARA [24] and small transverse bunch-sizes in the ultra-low emittance synchrotron light source MAX IV [21], [22], all conditions prone to instabilities leading to dynamic sub-structures in the charge density of the bunches. For the investigations, I conducted experimental studies and systematic simulations. +\subsection{Previous relevant work on beam dynamics, collective effects and diagnostics by Dr. Brosi} +In the last years, I have performed systematic studies of the longitudinal as well as transverse collective effects and instabilities influencing the bunch shape in all dimensions. The main goal was to investigate phenomena occurring under extreme operation modes to understand and circumvent resulting performance limitations while contributing to the general advancement of the field. The studied conditions included high charge in single bunches, dedicated short bunch-length operation modes at the storage ring KARA \cite{brosi_prab19}[24] and small transverse bunch-sizes in the ultra-low emittance synchrotron light source MAX IV [21], [22], all conditions prone to instabilities leading to dynamic sub-structures in the charge density of the bunches. For the investigations, I conducted experimental studies and systematic simulations. To evaluate the expected collective effects in the context of this proposal, simulations will be a valuable tool for which I have gained extensive experience in my previous research. For example, my studies of the micro-bunching instability, which occurs at bunch lengths in the order of several picoseconds or less, showed for example, an additional region of instability for certain parameters at lower bunch charge as predicted by the text-book equations [24]. To perform the theoretical calculations, I used the Vlasov-Fokker-Planck solver Inovesa [25], which simulates the longitudinal dynamics under the influence of the coherent synchrotron radiation impedance. To this end, the particle density distribution in the longitudinal phase space is calculated via the Vlasov-Fokker-Planck equation for each time step. I was involved in the scientific conceptualization of the code as well as testing the software and extensive benchmarking against measurements to assess the correctness of the results. Later, I extended the simulation to also include the influence of the geometric and resistive-wall impedance for studies of the micro-wave instability at MAX IV [21]. With these simulations I could very well reproduce the deformations in the longitudinal bunch shape observed experimentally (see Figure 2). \begin{figure}[b] @@ -147,6 +205,8 @@ My experience with the development of the fast readout system [28] as well as th The extensive research conducted in the field of accelerator physics today aims for a deep understanding of the involved beam dynamics and collective effects especially in beams under extreme conditions, like short bunch lengths or high intensities and the diagnostics thereof. At the same time, with RT moving to beams with high temporal or spatial structuring for novel methods including FLASH RT or MRT, this research becomes more and more relevant, laying out the program for the proposed project. +\printbibliography + \section{Work Packages?} To achieve the objectives, the work program is structured in the following work packages A-C:\\\vspace{0.5cm} @@ -166,7 +226,7 @@ To achieve the objectives, the work program is structured in the following work & & \textbf{A2.3} Extending model and simulation by incorporating collective effects \\ \cline{2-3} & \multicolumn{2}{p{0.72\textwidth}|}{\textbf{A3} Implementation of start-to-end simulation including beam dynamics and beam-matter interaction } \\ \hline - \multirow[t]{6}{0.2\textwidth}{\textbf{WP B}\\ Systematic investigation on temporal and spatial pulse shape dependence of detection mechanisms and diagnostic tools} & \multirow[t]{2}{0.27\textwidth}{\textbf{B1} For accelerator beam diagnostics } & \textbf{B1.1} Experimental tests (cf. to WP A1.1) \\ \cline{3-3} + \multirow[t]{6}{0.2\textwidth}{\textbf{WP B}\\ Systematic investigation on temporal and spatial pulse shape dependence of detection mechanisms and diagnostic tools} & \multirow[t]{2}{0.27\textwidth}{\textbf{B1} For accelerator beam diagnostics } & \textbf{B1.1} Experimental tests (cf. to WP A1.2) \\ \cline{3-3} & & \textbf{B1.2} Assess shot to shot resolution and provide recommendations for applicable methods depending on beam parameters \\ \cline{2-3} & \multirow[t]{3}{0.27\textwidth}{\textbf{B2} For dose and dose-rate diagnostics (dosimetry)} & \textbf{B2.1} Exp. test dependence of different dosimetry methods on pulse-property \\ \cline{3-3} & & \textbf{B2.2} Benchmark theoretical correction factors in dosimetry with respect to high dose rates \\ \cline{3-3} @@ -184,33 +244,43 @@ To achieve the objectives, the work program is structured in the following work \end{tabular} % \end{table} -\vspace{0.5cm} -WP A: As new, advanced radiotherapy modalities rely on high intensity, short or spatially structured particle beams, the influence of interactions between the beam particles will be increased compared to conventional radiotherapy. Work package A will study the influence of these collective effects on the beam in the accelerator as well as on the beam transport through matter onto the irradiation target. Sub-work package A1 will focus on the resulting beam dynamics during the beam generation in the accelerator by, firstly, conducting a case study of the influence of collective effects during the beam generation for FLASH and Microbeam RT in proposed, dedicated accelerators (WP A1.1). Established accelerator simulation tools, such as ASTRA, AT or Ocelot will be studied as each includes a different set of collective effects. WP A1.2 will use the linear accelerator FLUTE at KIT as a testbed and compare measurements and simulations of different beam parameters resembling the desired RT beam properties. The second sub-work package (WP A2) will focus on the influence of the extreme beam properties (high intensity, temporally and spatially structured) on the beam-matter interaction on the way from the accelerator to the target tissue inside the patient. In WP A2.1 the existing models and simulation tools used in beam transport trough matter will be reviewed and in WP A2.2 simulations with a variety of possible beam properties generated by FLUTE will be conducted with codes commonly employed in radiotherapy settings, like BDSIM (Geant4), EGSnrc, FLUKA and the new KiT-RT framework. WP A2.3 will investigate, in the context of beam-matter interaction, how different possible interactions between the beam particles themselves affect the passage through matter. To this end, collective effects known from accelerator physics, such as space charge, intra-beam scattering, transition or coherent synchrotron radiation effects and ion- or electron cloud effects (depending on the beam particle type) are evaluated and their relevance depending on beam properties estimated. As next step, in WP A3, the effects will be incorporated into the calculations for the beam transport through matter and combined with simulations of the dynamics in the accelerator to create a start-to-end simulation tool. Multiple options on how the different simulations and calculations are to be combined will be evaluated, in order to find the best implementation method for beam propagation simulation through the accelerator and matter interactions not only for single particles but also taking into account collective effects. Possible methods include Monte Carlo simulations, particle tracking, phase-space density propagation by solving the Vlasov-Fokker-Planck equation and the application of covariance matrices. The successful completion of WP A will deliver objective I. +% \vspace{0.2cm} +\subsection{WP A} +As new, advanced radiotherapy modalities rely on high intensity, short or spatially structured particle beams, the influence of interactions between the beam particles will be increased compared to conventional radiotherapy. Work package A will study the influence of these collective effects on the beam in the accelerator as well as on the beam transport through matter onto the irradiation target. Sub-work package A1 will focus on the resulting beam dynamics during the beam generation in the accelerator by, firstly, conducting a case study of the influence of collective effects during the beam generation for FLASH and Microbeam RT in proposed, dedicated accelerators (WP A1.1). Established accelerator simulation tools, such as ASTRA, AT or Ocelot will be studied as each includes a different set of collective effects. WP A1.2 will use the linear accelerator FLUTE at KIT as a testbed and compare measurements and simulations of different beam parameters resembling the desired RT beam properties. The second sub-work package (WP A2) will focus on the influence of the extreme beam properties (high intensity, temporally and spatially structured) on the beam-matter interaction on the way from the accelerator to the target tissue inside the patient. In WP A2.1 the existing models and simulation tools used in beam transport trough matter will be reviewed and in WP A2.2 simulations with a variety of possible beam properties generated by FLUTE will be conducted with codes commonly employed in radiotherapy settings, like BDSIM (Geant4), EGSnrc, FLUKA and the new KiT-RT framework. WP A2.3 will investigate, in the context of beam-matter interaction, how different possible interactions between the beam particles themselves affect the passage through matter. To this end, collective effects known from accelerator physics, such as space charge, intra-beam scattering, transition or coherent synchrotron radiation effects and ion- or electron cloud effects (depending on the beam particle type) are evaluated and their relevance depending on beam properties estimated. As next step, in WP A3, the effects will be incorporated into the calculations for the beam transport through matter and combined with simulations of the dynamics in the accelerator to create a start-to-end simulation tool. Multiple options on how the different simulations and calculations are to be combined will be evaluated, in order to find the best implementation method for beam propagation simulation through the accelerator and matter interactions not only for single particles but also taking into account collective effects. Possible methods include Monte Carlo simulations, particle tracking, phase-space density propagation by solving the Vlasov-Fokker-Planck equation and the application of covariance matrices. The successful completion of WP A will deliver objective I. -WP B: The extreme beam properties not only affect the beam propagation but also increase the complexity of applicable detection mechanisms and diagnostic tools. WP B1 will focus on accelerator-based beam diagnostic, such as fast beam current transformers, beam position monitors, fluorescence screens and more complex systems such as electro-optical bunch profile monitors [32], synchrotron or transition radiation monitors among others, with regards to their suitability for and ability to detect high intensity, temporally and spatially structured particle bunches with a high accuracy. Experimental tests are planed in WP B1.1 and will be compared with simulations from WP A1b. This will give input for the assessment in WP B1.2 on the potential of different diagnostic methods as support for RT beam diagnostics with shot to shot capabilities and the required adequate resolution and stability for medical applications. Work package B2 will focus on the effect the high dose rate generated by short beam pulses has on the dosimetry detectors. In WP B2.1, the ultra-short electron pulses from FLUTE and the ultra-short photon pulses generated at the KIT synchrotron light source with the electron storage ring KARA can be used for experimental tests of different dosimetry methods and their dependence on beam properties such as pulse length, intensity, transverse size and energy. As starting point an advanced Markus chamber and the newly-developed flash-diamond detector [8] will be tested towards the dependence on pulse length. Based on these measurements, also the recent developments of improved theoretical dosimetry correction factors for ion-recombination [7] can be validated with the ultra-short pulses (WP B2.2). And work package B2.3 will investigate possibilities for measuring a 2-dimensional dose distribution. For tests of the spatial resolution, the electron beam at FLUTE could be modulated, for example, by using collimators or potentially a mask at the accelerator exit. Furthermore, to measure the 2-dimensional particle distribution, typical accelerator diagnostics such as fluorescence screens for profile monitors will be assess for application outside the accelerator vacuum in WP B3 as preparation for WP C. In this context also detector test of new detector types under development at KIT, for example radiation hard CMOS-pixel detectors [33], could be incorporated as well as tests at facilities with proton or ion beams (e.g., HIT in Heidelberg or the GSI in Darmstadt). Completing WP B successfully will achieve objective II. +\subsection{WP B} +The extreme beam properties not only affect the beam propagation but also increase the complexity of applicable detection mechanisms and diagnostic tools. WP B1 will focus on accelerator-based beam diagnostic, such as fast beam current transformers, beam position monitors, fluorescence screens and more complex systems such as electro-optical bunch profile monitors [32], synchrotron or transition radiation monitors among others, with regards to their suitability for and ability to detect high intensity, temporally and spatially structured particle bunches with a high accuracy. Experimental tests are planed in WP B1.1 and will be compared with simulations from WP A1.2. This will give input for the assessment in WP B1.2 on the potential of different diagnostic methods as support for RT beam diagnostics with shot to shot capabilities and the required adequate resolution and stability for medical applications. Work package B2 will focus on the effect the high dose rate generated by short beam pulses has on the dosimetry detectors. In WP B2.1, the ultra-short electron pulses from FLUTE and the ultra-short photon pulses generated at the KIT synchrotron light source with the electron storage ring KARA can be used for experimental tests of different dosimetry methods and their dependence on beam properties such as pulse length, intensity, transverse size and energy. As starting point an advanced Markus chamber and the newly-developed flash-diamond detector [8] will be tested towards the dependence on pulse length. Based on these measurements, also the recent developments of improved theoretical dosimetry correction factors for ion-recombination [7] can be validated with the ultra-short pulses (WP B2.2). And work package B2.3 will investigate possibilities for measuring a 2-dimensional dose distribution. For tests of the spatial resolution, the electron beam at FLUTE could be modulated, for example, by using collimators or potentially a mask at the accelerator exit. Furthermore, to measure the 2-dimensional particle distribution, typical accelerator diagnostics such as fluorescence screens for profile monitors will be assess for application outside the accelerator vacuum in WP B3 as preparation for WP C. In this context also detector test of new detector types under development at KIT, for example radiation hard CMOS-pixel detectors [33], could be incorporated as well as tests at facilities with proton or ion beams (e.g., HIT in Heidelberg or the GSI in Darmstadt). Completing WP B successfully will achieve objective II. -WP C: This work package aims to understand the physical and theoretical limits of accelerator-based beam modulation and shaping for the application in radiotherapy. The first step (WP C1) will be to explore different methods for temporal and spatial manipulation of the beam shape. This will be based, firstly, on simulations exploring a variety of options for different possible accelerator types operating as RT sources (WP C1.1). One general option would be, for example, to employ the accelerator focusing magnets to modify the bunch shape, by over-focusing the beam at the accelerator exit. Secondly, in WP C1.2, the possibility on modulations of the source distribution, will be experimentally tested by modulating the gun laser spot on the electron-gun with the spatial light modulator set-up a FLUTE [16]. The second step (WP C2) includes then the investigation of the evolution of the modulated bunch shape during the transport through the accelerator and through matter on to the target. The investigation of the bunch shape evolution will consist of simulations (WP C2.1) based on the results in work package A, which can then be compared with experimental measurements in WP C2.2, using the diagnostics tested in WP B. Upon finishing WP C1+C2, we can attain objective III. +\subsection{WP C} +This work package aims to understand the physical and theoretical limits of accelerator-based beam modulation and shaping for the application in radiotherapy. The first step (WP C1) will be to explore different methods for temporal and spatial manipulation of the beam shape. This will be based, firstly, on simulations exploring a variety of options for different possible accelerator types operating as RT sources (WP C1.1). One general option would be, for example, to employ the accelerator focusing magnets to modify the bunch shape, by over-focusing the beam at the accelerator exit. Secondly, in WP C1.2, the possibility on modulations of the source distribution, will be experimentally tested by modulating the gun laser spot on the electron-gun with the spatial light modulator set-up a FLUTE [16]. The second step (WP C2) includes then the investigation of the evolution of the modulated bunch shape during the transport through the accelerator and through matter on to the target. The investigation of the bunch shape evolution will consist of simulations (WP C2.1) based on the results in work package A, which can then be compared with experimental measurements in WP C2.2, using the diagnostics tested in WP B. Upon finishing WP C1+C2, we can attain objective III. WP C3 and C4, will then investigate how and to what extend it is possible to generate a custom particle distribution and thereby a custom dose distribution on target tissue. To this end, WP C3, will examine possible methods and algorithms for calculating, based on a desired final distributions, the required, corresponding initial particle distribution in the accelerator. As this work will build on the work from work package A3, especially on the designed start-to-end simulation, the optimal methods will likely depend on the algorithm chosen in WP A3. Several possible methods can be imagined, ranging from systematically mapping final distributions for a wide variety of initial distributions resulting in a type of catalog, over the analytical or numerical inversion of the transport matrix described in form of covariance matrices, up to employing machine learning algorithms trained on arbitrary bunch shapes propagated through the start-to-end simulation. When this connection between the final and the initial distribution is established, it can be combined with the beam modulation methods established in WP C1. WP C4.1 will, as a first step, employ this to compensate the effect the beam transport has on the pulse shape by considering these deformations already during the beam generation. And in WP C4.2 the capability of this method will be tested and the limits in the achievable distributions on target will be explored. With this, the last objective (IV.) will be achieved. \section{Work Plan?} \subsection{Time plan} +\color{blue} +The time line of the different work packages is displayed as a Gantt diagram in Figure \ref{fig:timeplan}. +The individual work packages are color-coded according to the responsible team member. In the lower part of the figure, the planned time frame of each team member within the project is depicted. +The exact time plan may be subject to change, depending on the research progresses. Any significant deviations from the original time plan will be communicated to the Helmholtz Association, in order to guarantee the best outcome for the project. + +\color{black} + \begin{figure}[!h] \centering \includegraphics[trim=0mm 0mm 0mm 0mm, clip,width=1\textwidth]{plots/gantt_HH.pdf} -\caption{Time plan showing the individual work packages colorcoded by responsible team member as well as the time frame of each team members within the project in the lower part.} +\caption{Time plan showing the individual work packages color-coded by responsible team member as well as the time frame of each team members within the project in the lower part.} \label{fig:timeplan} \end{figure} \subsection{Group structure} -The work program is designed for me as group leader and a total of 2 postdoctoral researchers and 2 doctoral students. There will be one postdoctoral researcher and one doctoral student in the first haft of the project and the same number in the second half, with half a year overlap between the doctoral students in the middle (see Figure 3 lower part). +The work program is designed for me as group leader and a total of 2 postdoctoral researchers and 2 doctoral students. There will be one postdoctoral researcher and one doctoral student in the first haft of the project and the same number in the second half, with a year overlap between the doctoral students in year 3 (see Figure \ref{fig:timeplan} lower part). To generally coordinate the work efforts and discuss outcomes and upcoming steps a weekly team meeting will be established. In addition, regular bi-weekly work package specific meetings will take place focusing on the respective challenges and problems to solve. For doctoral students, additionally, a weekly one-on-one meeting with me about their individual progress is intended which will give them the possibility to ask question in a more confidential and relaxed setting. In total, each team member should have no more than 3 regular meetings per week not including spontaneous discussions as well as more relaxed coffee break conversations. -The work of this project will be distributed, as described in the following, onto the planned group members with the time schedule shown in the graph below (Figure 3): +The work of this project will be distributed, as described in the following, onto the planned group members with the time schedule shown in the graph in Figure \ref{fig:timeplan}: \textbf{Doctoral student (PhD 1)} (starting between month 1 and 6, 3 years duration):\\ Research topic: Experimental study of the influence of advanced radiotherapy beam properties such as short bunch length, charge, energy and transverse size on accelerator beam dynamics, diagnostics and detected dose. The research will mainly focus on experimental measurements of the effects of extreme beam properties at the linear accelerator FLUTE accompanied by supporting simulations and will contribute to work packages A1.2, A2.2, B1 and B2.1. @@ -229,29 +299,45 @@ Besides my planned involvement in lectures, I, as group leader, will coordinate In shared work packages, the work will be distributed by subtopic and a close communication will be maintained with the corresponding team member. -It is envisioned to give master students the possibility to contribute in different work packages. Possibilities would be, for example, in WP A3 (supervised by the first postdoctoral researcher) by testing different implementation possibilities for collective effects in beam-matter interactions, or setting up a new diagnostics system in the scope of WP B3 or also WP C2.2 supervised by the second postdoctoral researcher. It would offer a great opportunity for the postdoctoral researchers to gather experience in supervising students. And furthermore, student assistants will support the project for example during experiments and measurement campaigns, with documentation, data organization or implementing specific data analysis scripts. +It is envisioned to give master students the possibility to contribute in different work packages. Possibilities would be, for example, in WP A3 (supervised by the first postdoctoral researcher) by testing different implementation possibilities for collective effects in beam-matter interactions, or setting up a new diagnostics system in the scope of WP B3 or also WP C2.2 supervised by the second postdoctoral researcher. It would offer a great opportunity for the postdoctoral researchers to gather experience in supervising students. Student assistants will support the project for example during experiments and measurement campaigns, with documentation, data organization or implementing specific data analysis scripts. \color{blue} +This will, furthermore, be a good opportunity to get students involved and interested in the research field and can help attract students for Master thesis. +\color{black} -\subsection{Scientific equipment} +\subsection{Existing scientific equipment and infrastructure} +\color{blue} +The proposed project profits from the following research infrastructure and scientific equipment, which is available at the Institute for Beam Physics and Technology as well as KIT in general: - • Far-infrared linac and test experiment (FLUTE) - ◦ Linear electron accelerator - ◦ Extensive accelerator diagnostic for beam characterization, including beam charge, position, profile and energy measurements - ◦ Water-equivalent RW3 slab phantom from PTW for dosimetry measurements - ◦ Electrometer UNIDOS Tango from PTW for dosimetry measurements +\begin{itemize} + \item Far-infrared linac and test experiment (FLUTE) + \begin{itemize} + \item Linear electron accelerator + \item Extensive accelerator diagnostic for beam characterization, including beam charge, position, profile and energy measurements + \item Water-equivalent RW3 slab phantom from PTW for dosimetry measurements + \item Electrometer UNIDOS Tango from PTW for dosimetry measurements + \end{itemize} - • Karlsruhe Research Accelerator (KARA) - ◦ Electron storage ring based synchrotron light-source - ◦ Extensive accelerator diagnostic for beam characterization, including beam and bunch charge, position, profile, and synchrotron light monitors +\item Karlsruhe Research Accelerator (KARA) +\begin{itemize} + \item Electron storage ring based synchrotron light-source + \item Extensive accelerator diagnostic for beam characterization, including beam and bunch charge, position, profile, and synchrotron light monitors +\end{itemize} - • HoreKa (Hochleistungsrechner Karlsruhe) - ◦ High performance computing center - ◦ Access based on project proposals - ◦ Free of charge + \item HoreKa (Hochleistungsrechner Karlsruhe) + \begin{itemize} + \item High performance computing center + \item Access based on project proposals +% \item Free of charge + \end{itemize} - • bwUniCluster - ◦ High performance computing center - ◦ Access granted on university level - ◦ Free of charge + \item bwUniCluster + \begin{itemize} + \item High performance computing center + \item Access granted on university level +% \item Free of charge + \end{itemize} +\end{itemize} + +\color{black} \subsection{Handling of research data/Research data plan} @@ -269,139 +355,103 @@ Group members will be provided with the possibility to learn the usage of techno \subsection{Financial plan} -Brosi, Miriam Katharina: -To lead the proposed project in the Emmy Noether programme, the funding for the position as junior research group leader is requested for the expected project duration of 6 years consisting of two funding periods (36 + 36 months). The position will be filled by applicant, Miriam Katharina Brosi. -Personnel Cost Category -EUR / year (as of 2024) -EUR / Sum (6 years)* -Head of independent junior research group -100200 -648135 -*An annual rise of 3% in personnel costs has been included. +The following section is a more detailed description of the financial plan the table in Annex 7. -5.2.1 Funding for Staff +\subsubsection{Personnel costs} +\color{blue} +The personnel costs follow the DFG personnel rates from 2024. An annual rise of 3\% is included starting already from the first year, to adjust for the potential starting date laying in 2025. -For the proposed work program the funding for two doctoral students, two postdoctoral researchers, and several student workers is requested. +To lead the proposed project, the funding for the position as junior research group leader is requested for the whole project duration of 5 years. The position will be filled by the applicant, Dr. Miriam Brosi. +% Personnel Cost Category +% EUR / year (as of 2024) +% EUR / Sum (6 years)* +% Head of independent junior research group +% 100200 +% 648135 +% *An annual rise of 3\% in personnel costs has been included. +\color{black} + +% 5.2.1 Funding for Staff + +For the proposed work program the funding for two doctoral students, two postdoctoral researchers, and several student workers is included. The first doctoral student will be employed for three years on a 75\% position and is planned to start shortly after the project start, latest after half a year (1-6 month after project start). The PhD thesis will be on the topic of: Experimental study of the influence of advanced radiotherapy beam properties such as short bunch length, charge, energy and transverse size on accelerator beam dynamics, diagnostics and detected dose. The candidate should have some experience in experimental work, including setting up and handling sensitive diagnostic hardware. This topic offers a round work package suited to result in a PhD thesis. It offers opportunities for the student to shape and combine different tasks according to their own vision to deliver the independent research results required for a dissertation, while still receiving the required guidance. -The second doctoral student will be employed for three years on a 75\% position. This position should start in the second half of project year 3 (30 month after project start). The work will focus on: Investigation of theoretical methods and algorithms to solve the inverse problem of custom accelerator-based beam modulation for advance radiotherapy. A candidate is envisioned with a background or strong motivation in mathematical methods and computational physics. For this project the doctoral student would have the possibility and time to evaluate different possible methods towards their feasibility fo the project goal while collecting experience and learn about all of them. This will result for the project in a good overview of the available methods while also providing the student with a broad knowledge for their following career steps. +The second doctoral student will be employed for three years on a 75\% position. This position should start in the beginning of project year three (24 month after project start). The work will focus on: Investigation of theoretical methods and algorithms to solve the inverse problem of custom accelerator-based beam modulation for advance radiotherapy. A candidate is envisioned with a background or strong motivation in mathematical methods and computational physics. For this project the doctoral student would have the possibility and time to evaluate different possible methods towards their feasibility for the project objective IV. while collecting experience and in-depth knowledge in all of them. This will result for the project in a good overview of the available methods while also providing the student with a broad knowledge for their following career steps. -For both doctoral students, to allow for some unplanned, but not uncommon, delays, due to e.g., unexpected down times of accelerators or other technical challenges, during the work on the PhD thesis, an additional, optional half year per doctoral position is requested, so that the contract could be extended to prevent financial stress for the students during the final stage of their thesis. +% For both doctoral students, to allow for some unplanned, but not uncommon, delays, due to e.g., unexpected down times of accelerators or other technical challenges, during the work on the PhD thesis, an additional, optional half year per doctoral position is requested, so that the contract could be extended to prevent financial stress for the students during the final stage of their thesis. -The first postdoctoral researcher will be employed for two years on a 100\% position and is planned to start at the beginning of the second project year (12 month after project start). The planned work will include the incorporation of collective effects into beam-matter interaction and the implementation of a start-to-end simulation combining beam transport simulations in the accelerator with simulations of the transport through matter. A candidate with a strong background in many-particle systems, radiation transport through matter, or theoretical accelerator physics with experience in simulation programming is envisioned. The higher level of prior experience and knowledge required for this task, is more suited for a postdoctoral researcher position (compared to a doctoral student), which would furthermore allow the researcher to work as a more independent team member. +The first postdoctoral researcher will be employed for two years on a 100\% position and is planned to start after the first half of the first project year (6 month after project start). The planned work will include the incorporation of collective effects into beam-matter interaction and the implementation of a start-to-end simulation combining beam transport simulations in the accelerator with simulations of the transport through matter. A candidate with a strong background in many-particle systems, radiation transport through matter, or theoretical accelerator physics with experience in simulation programming is envisioned. The higher level of prior experience and knowledge required for this task, is more suited for a postdoctoral researcher position (compared to a doctoral student), which would furthermore allow the researcher to work as a more independent team member. -The second postdoctoral researcher will be employed with 100\% for two years and is planned to start at the beginning of the fourth project year (36 month after project start). Due to the experimental nature of the assigned work packages, an experimental physicist with an extensive background in fast, time-resolved diagnostics and detectors as well as short pulse physics would be suitable. Alternatively, an electrical engineer working in detector development for 2-dimensional pulse detection with some basic experience in accelerator physics would be a good fit. In order to ensure a continuous progress in this stage of the project, the tasks should be carried out by a postdoctoral researcher who, due to previous experience can more efficiently solve upcoming challenges. Additionally, the project will benefit from the contribution of prior knowledge in fields such as detector engineering and from the capability of the postdoctoral researcher to supervise a master student. At the same time, would the increased independence of the postdoctoral researcher allow them to define their own research profile and gain experience in supervision. +The second postdoctoral researcher will be employed with 100\% for two years and is planned to start in the second half of the third project year (30 month after project start). Due to the experimental nature of the assigned work packages, an experimental physicist with an extensive background in fast, time-resolved diagnostics and detectors as well as short pulse physics would be suitable. Alternatively, an electrical engineer working in detector development for 2-dimensional pulse detection with some basic experience in accelerator physics would be a good fit. In order to ensure a continuous progress in this stage of the project, the tasks should be carried out by a postdoctoral researcher who, due to previous experience can more efficiently solve upcoming challenges. Additionally, the project will benefit from the contribution of prior knowledge in fields such as detector engineering and from the capability of the postdoctoral researcher to supervise a master student. At the same time, would the increased independence of the postdoctoral researcher allow them to define their own research profile and gain experience in supervision. Additionally, some funds are requested to employ student assistants for a total of 3 years distributed over the project duration as required and interested students availability. The working time will be adjusted in such a way that the monthly salary corresponds to a “Minijob” (in 2024: €538/month maximum net salary) according to the customary rates for student assistants at KIT (in 2024: without completed master degree, €13.25/h netto). This results in a maximum of 40 working hours per month. The tasks will include support for setup, execution and documentation of experiments. -Personnel Cost Category -Start year -EUR / year (as of 2024) -EUR / Sum (6 years)* -Postdoctoral researcher (100%) (2 years) -2 -86100 -180026 -Postdoctoral researcher (100%) (2 years) -4 -86100 -193897 -Doctoral researcher (75%) -(3 years) -1 -59850 -184990 -Doctoral researcher (75%) -(3 years) -3 -59850 -196256 -Extension possibility for Doctoral researchers (75%) -(in total 1 year) -4 \& 6 -59850 -65400 -Student assistants -(in total 3 years) -distributed -8736 -28394 -Sum +{ \centering +\renewcommand{\arraystretch}{1.2} % Default value: 1 +\begin{tabular}{|l|r|r|} +\hline +Personnel Cost Category & EUR / year (as of 2024) & EUR / Sum (5 years)*\\\hline +Head of research group & 100200 & 547935\\ +2 x Postdoctoral researcher (100\%) & 86100 & 376582 \\ +2 x Doctoral researcher (75\%) & 59850 & 392685 \\ +Student assistants & 8736 & 26208\\ \hline +\end{tabular}} +*An annual rise of 3\% has been included. -848963 -*An annual rise of 3% in personnel costs has been included. - +\subsubsection{Material costs} Besides the accelerators, diagnostic tools and equipment already available at the host institute, the funding for the following items are requested. Two different dosimeter types will be bought for systematic and comparative measurements under different beam conditions and pulse lengths. The Advanced Markus Chamber is a plane-parallel ionization chamber with a small sensitive volume, suited for high dose per pulse conditions. The second selected detector is the flashDiamond, a synthetic single crystal diamond detector, recently developed for ultra-high dose rates. The detectors are from PTW Freiburg GmbH and were specifically selected to be compatible with the electrometer and slab phantom from the same company available at the institute. For measuring the 2-dimensional dose distribution, radiographic films will be used, for example GAFCHROMIC EBT3 or Kodak EDR2. Since the films are consumables, multiple boxes (à €1000) will be required. A total cost of €10000 is estimated over the project duration. A humidity logger in the experimental hall will be used during beam propagation measurements in air. An estimate of €1000 is requested to this end. For complementary electronics accessories, such as signal cables, adapters and connectors for detector readout and power supplies a fixed amount of €7000 is estimated. An additional €5000 is requested for supplementary readout electronics such as amplifiers or attenuators for detector signals as well as trigger signals from the accelerator systems. Mounting materials to e.g., build mounts for detector systems or other constructions required for experiments are estimated with a total of €5000 during the project duration. Optical components are planned with €10000 to cover lenses, mirrors, mounts, and further laser laboratory supplies for the experiments with the spatial light modulator. A dedicated PC is forseen as control and read-out station for the experiments. This will allow a fast handling and post-processing of results including the augmentation with additional meta-information. Portable hard drives will be used to quickly transfer working copies of the results for further analysis. -Equipment -Cost / € -flashDiamond dosimetry detector (PTW) -9500 -Advanced Markus Chamber dosimetry detector (PTW) -2700 -Radiographic films -10000 -Humidity+temperature logger -1000 -Electronics accessories -7000 -Supplementary readout electronics -5000 -Mounting materials -5000 -Optical components and lab supplies -10000 -Experimental control PC + portable hard drives -5000 -Sum -55200 +{ \centering +% \setlength{\tabcolsep}{10pt} % Default value: 6pt +\renewcommand{\arraystretch}{1.2} % Default value: 1 +% \begin{tblr}{|@{}X[l]|r@{}|} +\begin{tabular}{|l|r|} +\hline +Equipment & Cost / EUR\\\hline +flashDiamond dosimetry detector (PTW) & 9500\\ +Advanced Markus Chamber dosimetry detector (PTW) & 2700\\ +Radiographic films & 10000 \\ +Humidity+temperature logger & 1000 \\ +Electronics accessories & 7000 \\ +Supplementary readout electronics & 5000 \\ +Mounting materials & 5000 \\ +Optical components and lab supplies & 10000 \\ +Experimental control PC + portable hard drives & 5000 \\ \hline +% Sum & 55200 \\ \hline +% \end{tblr}} +\end{tabular}} + +\subsubsection{Travel costs} The participation in relevant conferences and workshops will enable the communication and discussion of results as well as help with establishing new connections and give access to the latest developments. For the travel to international conferences an average cost of €2500 is allocated, which also contains conference fees (e.g., typically around €700 for the international particle accelerator conference (IPAC)) and assumes a total trip duration of 6-7 days. For national travels an amount of €1500 is estimated to cover travels of up to 6 days. For me, in the role of group leader, an average of one international and one national trip per year is envisioned. For each doctoral researcher one international trip and two national trips are allocated within their contract duration, this could include a summer-school within Europe, e.g., Cern Accelerator School. For each postdoctoral researcher two international trips are planned. For all potential master students together, a total of three national trips to the DPG spring meetings are planned, to give them the possibility to present their research for the first time to a wider community out-side the university setting. This amounts to following funds: -Number of travels -International -National -Sum / Euro -Doctoral researcher 1 -1 -2 -5500 -Doctoral researcher 2 -1 -2 -5500 -Postdoctoral researcher 1 -2 -5000 -Postdoctoral researcher 2 -2 +{ \centering +\renewcommand{\arraystretch}{1.2} % Default value: 1 +\begin{tabular}{|l|r|r|r|} +\hline +Personnel & \# International travels & \# National travels & Sum / EUR\\\hline +Doctoral researcher 1 & 1&2& 5500\\ +Doctoral researcher 2&1&2&5500\\ +Postdoctoral researcher 1&2&&5000\\ +Postdoctoral researcher 2&2&&5000\\ +Group leader&6&6&20000\\ +Master students (in total)&&3&4500\\ \hline +\end{tabular}} -5000 -Group leader -6 -6 -24000 -Master students (in total) - -3 -4500 -Sum -12 -13 -49500 \section{Cooperation and communication plan?} +\color{red} • Prof. Dr Oliver Jäkel (in ch.), Heidelberg University and Heidelberger Ionenstrahl Therapiezentrum (HIT) and Division Head of “Medical Physics in Radiation Oncology” Deutsches Krebsforschungszentrum (DKFZ). @@ -415,6 +465,16 @@ Sum • Dr. Lennart Volz, Medical physicist, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, expert on ion-based radiotherapy, particle imaging and treatment planning. +\color{blue} + +Envisioned cooperations: The closest cooperation with be with the Institute for Beam Physics and Technology (IBPT) where the group will be situated. This will give easy and extended access to the accelerator test-facilities FLUTE, KARA, as well as the planned storage ring cSTART and a laser-wakefield accelerator under construction. The Accelerator Technology Platform (ATP) at KIT will provide an extensive infrastructure for accelerator research as well as a close connection to the detector development at the Institute for Data Processing and Electronics (IPE). Cooperations with Prof. Dr. Oliver Jäkel from the Heidelberg Ion Beam Therapy Center (HIT) and German Cancer Research Center (DKFZ), as well as with Prof. Dr.-Ing. Christian Graeff and Dr. Lennart Volz from the GSI Helmholtz center for Heavy Ion Research are planned. Initial discussions +with Prof. De Carne (ITEP) have been initiated on the topic of energy efficient and sustainable accelerators for medical applications, and spin-off projects from this Helmholtz IG will be planned in the future. + + +The participation in relevant conferences such as the International Particle +Accelerator conference (IPAC) or the Flash Radiotherapy and Particle Therapy conference (FRPT) and smaller workshops will enable the communication and discussion of results as well as help to establish new connections and provide access to the latest developments. For master students trips to the DPG spring +meetings are planned, as first opportunity to present their research to a wider community. Research results will furthermore be published in, preferably, open access journals and presented at Helmholtz meetings. + % \lipsum % \lipsum diff --git a/Helmholtz/full_poposal/proposal_text/proposal.toc b/Helmholtz/full_poposal/proposal_text/proposal.toc index d49488b..b411ca3 100644 --- a/Helmholtz/full_poposal/proposal_text/proposal.toc +++ b/Helmholtz/full_poposal/proposal_text/proposal.toc @@ -3,15 +3,21 @@ \contentsline {section}{\numberline {3}Relation to Research Programme of IBPT and KIT?}{3}{}% \contentsline {section}{\numberline {4}Current Status of Research?/State of the art and preliminary work?}{4}{}% \contentsline {subsection}{\numberline {4.1}State of the art: radiotherapy}{4}{}% -\contentsline {subsection}{\numberline {4.2}State of the art: accelerators and collective effects}{5}{}% +\contentsline {subsection}{\numberline {4.2}State of the art: accelerators and collective effects}{6}{}% \contentsline {subsection}{\numberline {4.3}Open questions and challenges? not here???}{7}{}% -\contentsline {subsection}{\numberline {4.4}Previous relevant work of Dr. Brosi?/Preliminary work on beam dynamics, collective effects and diagnostics}{7}{}% -\contentsline {section}{\numberline {5}Work Packages?}{9}{}% -\contentsline {section}{\numberline {6}Work Plan?}{11}{}% -\contentsline {subsection}{\numberline {6.1}Time plan}{11}{}% +\contentsline {subsection}{\numberline {4.4}Previous relevant work on beam dynamics, collective effects and diagnostics by Dr. Brosi}{7}{}% +\contentsline {section}{\numberline {5}Work Packages?}{10}{}% +\contentsline {subsection}{\numberline {5.1}WP A}{10}{}% +\contentsline {subsection}{\numberline {5.2}WP B}{11}{}% +\contentsline {subsection}{\numberline {5.3}WP C}{11}{}% +\contentsline {section}{\numberline {6}Work Plan?}{12}{}% +\contentsline {subsection}{\numberline {6.1}Time plan}{12}{}% \contentsline {subsection}{\numberline {6.2}Group structure}{12}{}% -\contentsline {subsection}{\numberline {6.3}Scientific equipment}{13}{}% -\contentsline {subsection}{\numberline {6.4}Handling of research data/Research data plan}{13}{}% -\contentsline {subsection}{\numberline {6.5}Financial plan}{14}{}% -\contentsline {section}{\numberline {7}Cooperation and communication plan?}{16}{}% +\contentsline {subsection}{\numberline {6.3}Existing scientific equipment and infrastructure}{14}{}% +\contentsline {subsection}{\numberline {6.4}Handling of research data/Research data plan}{14}{}% +\contentsline {subsection}{\numberline {6.5}Financial plan}{16}{}% +\contentsline {subsubsection}{\numberline {6.5.1}Personnel costs}{16}{}% +\contentsline {subsubsection}{\numberline {6.5.2}Material costs}{17}{}% +\contentsline {subsubsection}{\numberline {6.5.3}Travel costs}{17}{}% +\contentsline {section}{\numberline {7}Cooperation and communication plan?}{18}{}% \providecommand \tocbasic@end@toc@file {}\tocbasic@end@toc@file diff --git a/Helmholtz/full_poposal/publication_list_2024-04_helmholtz_with_awards.pdf b/Helmholtz/full_poposal/publication_list_2024-04_helmholtz_with_awards.pdf new file mode 100644 index 0000000..977b988 Binary files /dev/null and b/Helmholtz/full_poposal/publication_list_2024-04_helmholtz_with_awards.pdf differ diff --git a/Helmholtz/full_poposal/summary_200words b/Helmholtz/full_poposal/summary_200words new file mode 100644 index 0000000..5f525e0 --- /dev/null +++ b/Helmholtz/full_poposal/summary_200words @@ -0,0 +1,85 @@ +The proposed project will investigate temporally and spatially structured accelerator-generated beams required for novel radiotherapy (RT) methods, such as FLASH and Microbeam RT. +The main focus will be the investigation of the involved accelerator physics regarding collective effects in these complex beams. +The coexistence of many particles in the used, densely populated pulses causes strong effects, i.e. collective effects, which originate from interactions of particles within the beam and with the environment. +In particular, the consideration of collective effects will be extended into the beam-matter interaction outside of the accelerator. +Thereby, the project aims for a greatly improved predictability of the beam properties on the target. +This, combined with a systematic study of applicable diagnostic methods, will form the basis for research into the possibilities and physical limits of accelerator-based pulse shaping and modulation, with the aim of generating custom, predefined beam shapes for radiotherapy within this project. +Even beyond this application, the proposed project has the potential to resolve a fundamental limitation inherent to all applications of high-intensity, short-duration particle pulses by improved understanding, predictability and potential control of similarly complex beams. + +...Due to extrem properties.. Kollektive effects consideration crucial for... Goal of predicting... .. + +DEUTSCH: +Im Rahmen des vorgeschlagenen Projekts werden zeitlich und räumlich strukturierte, von Beschleunigern erzeugte Teilchenstrahlen stehen, die für neuartige Strahlentherapieverfahren (radiotherapy = RT) wie FLASH und Microbeam RT benötigt werden. + +%Der Schwerpunkt liegt dabei auf der Untersuchung der beteiligten Beschleunigerphysik, insbesondere im Hinblick auf kollektive Effekte innerhalb dieser komplexen Strahlen. +Der Schwerpunkt liegt dabei auf der beteiligten Beschleunigerphysik, insbesondere der Untersuchung kollektiver Effekte innerhalb dieser komplexen Strahlen. +Die Koexistenz vieler Teilchen in den verwendeten, dicht besetzten Pulsen führt zu starken kollektiven Effekten, und daraus folgenden Strahlverformungen oder Instabilitäten, die durch Wechselwirkungen der Teilchen untereinander innerhalb des Strahls sowie des Teilchenensembles mit der Umgebung entstehen. +Insbesondere soll die Betrachtung der kollektiven Effekte auf die Strahl-Materie-Wechselwirkung außerhalb des Beschleunigers ausgedehnt werden. +Dadurch soll(???) die Vorhersagbarkeit der Strahleigenschaften auf dem Target erheblich präzisiert werden. +In Verbindung mit einer systematischen Untersuchung geeigneter Diagnosemethoden bildet dies die Grundlage für die Erforschung der Möglichkeiten und physikalischen Grenzen von beschleunigerbasierter Pulsformung und -modulation, mit dem Ziel, im Rahmen dieses Projekts, Methoden zu Erzeugung maßgeschneiderter, vordefinierter Strahlverteilungen für die Strahlentherapie/FLASH und Microbeam RT zu entwickeln und zu demonstrieren (first tests???). + +Auch über diese Anwendung hinaus, hat das vorgeschlagene Projekt das Potenzial, eine grundlegende Beschränkung zu überwinden, die allen Anwendungen von Teilchenpulsen hoher Intensität und kurzer Dauer innewohnt, indem es das Verständnis, die Vorhersagbarkeit und die Möglichkeit zur Kontrolle ähnlich komplexer Teilchenstrahlen verbessert/vorantreibt(?). + +...und zwar durch ein besseres Verständnis, eine bessere Vorhersagbarkeit und eine mögliche Kontrolle ähnlich komplexer Strahlen. + +...die durch Wechselwirkungen innerhalb des Teilchenensembles sowie dessen(??) mit der Umgebung entstehen. + +...In Verbindung mit einer systematischen Untersuchung geeigneter Diagnosemethoden bildet dies die Grundlage für die Erforschung der Möglichkeiten und physikalischen Grenzen von beschleunigerbasierter Pulsformung und -modulation. Im Rahmen dieses Projekts, sollen Methoden zu Erzeugung maßgeschneiderter, vordefinierter Strahlverteilungen für die Strahlentherapie/FLASH und Microbeam RT entwickelt und demonstriert werden. +...Which will be a strong/important contribution to the advancement of ... +...Mit dieser Art von Kontrolle wird das Ergebnis des Projekts einen bedeutenden Beitrag zu FLASH und Microbeam RT (sowie zu allgemeinen Fortschritten in der Beschleunigerphysik) darstellen. + +...Auch über diese Anwendung hinaus, hat das vorgeschlagene Projekt das Potenzial zu Anwendungen von Teilchenpulsen hoher Intensität und kurzer Dauer beizutragen, indem es das Verständnis, die Vorhersagbarkeit und die Möglichkeit zur Kontrolle dieser komplexen Teilchenstrahlen verbessert. + +...Auch über diese Anwendung hinaus, hat das vorgeschlagene Projekt das Potenzial zum allgemeinen Fortschritt von Anwendungen von Teilchenpulsen hoher Intensität und kurzer Dauer (in der Beschleunigerphysik) beizutragen, indem es das Verständnis, die Vorhersagbarkeit und die Möglichkeit zur Kontrolle dieser komplexen Teilchenstrahlen vorantreibt. + +--------------------- +---------------------- + +Particle accelerators play a vital role in a multitude of scientific fields such as the field of radiotherapy (RT). Novel radiotherapy methods, such as FLASH RT (very high doses in short pulses) and Microbeam RT (spatially fractionated pulses), are based on temporally and spatially structured accelerator-based particle beams with high requirements on their properties. These requirements cause strong effects caused by the coexistence of many particles in the densely populated pulses, summarized under the term collective effects, for which the knowledge of influence on relativistic particle beams, with properties used in the novel RT methods, is currently incomplete. As these can affect the dose distribution on target, an important aspect for radiotherapy, the investigation of collective effects for such beams is of the essence. The proposed project will improve the understanding to increase the predictability and enhance control of accelerator-based electron beams. This will be applied to beams for FLASH RT and Microbeam RT. It will furthermore study applicable detection methods and assess possibilities as well as limitations of temporal and spatial pulse shaping and modulation of accelerator-based RT beams with the ultimate goal to generate custom beam shapes and dose distributions on target. + +-------------------------- +--------------------- + + +Likewise, this allows very new and exciting insight into relativistic particle behavior and, finally, will enable novel and resource-efficient operation modes of accelerators. When applied to linear accelerators for medical purpose, this approach has the potential to resolve a fundamental limitation inherent to all applications of high-intensity, short-duration particle pulses by improved understanding, predictability and potential control of these challenging beams. + +---- +The consideration of these effects in particular by extending the consideration of collective effects into the beam-matter interaction outside of the accelerator will greatly improve the predictability of the beam properties on the target. + +--- +These complex beams cause strong effects through the coexistence of many particles in densely populated bunches which lead to interactions of particles within the beam as well as with the environment, both depending on the detailed particle distribution. +To greatly improve the predictability of beam properties, the main focus +of this project will be the investigation of the involved accelerator physics in terms of +the influence of collective effects in particular by extending the consideration thereof into the beam-matter interaction outside of the accelerator. + +-- +The main focus will be the investigation of the involved accelerator physics regarding collective effects in these complex beams. +These strong (collective) effects are caused by the coexistence of many particles in densely populated bunches leading to interactions of particles within the beam as well as with the environment, both depending on the detailed particle distribution. + +The coexistence of many particles in the used densely populated beams cause strong effects, i.e. collective effects, which originate from interactions of particles within the beam as well as with the environment. + +The coexistence of many particles in densely populated bunches cause strong effects summarised under the term collective effects. +. +The consideration of these effects in particular by ... will greatly improve... + +These will be considered in particular by extending the consideration of collective effects into the beam-matter interaction outside of the accelerator. +The project thereby aims for a greatly improved predictability of the beam properties on the target. + +This, combined with a systematic study of applicable diagnostic methods, will form the basis for research into the possibilities and physical limits of accelerator-based pulse shaping and modulation, with the aim of generating predefined beam shapes for medical applications. + + +Likewise, this allows very new and exciting insight into relativistic particle behavior and, finally, will enable to novel and resource-efficient operation modes of accelerators. When applied to linear accelerators for medical purpose, this approach has the potential to resolve a fundamental limitation inherent to all applications of high-intensity, short-duration particle pulses by improved understanding, predictability and potential control of these challenging beams. + + +---- +The main focus will be the investigation of the involved accelerator physics in terms of +the influence of collective effects on the dynamics for these complex beams in particular by extending the consideration of collective effects into the beam-matter interaction outside of the accelerator. +The project thereby aims for a greatly improved predictability of the beam properties on the target. +---- +By furthering the accelerator physics understanding through investigating +the influence of collective effects on the dynamics for these complex beams, +the project aims for a greatly improved predictability of the beam properties. + +A substantial contribution to this will be by extending the consideration of collective effects into the beam-matter interaction outside of the accelerator + +The main point will be extending the consideration of collective effects into the beam-matter interaction outside of the accelerator diff --git a/RadMeasureManual10.pdf b/RadMeasureManual10.pdf new file mode 100644 index 0000000..46c967e Binary files /dev/null and b/RadMeasureManual10.pdf differ diff --git a/emmy_noether/53_05_en_elan_projectdescription_draft_formated.odt b/emmy_noether/53_05_en_elan_projectdescription_draft_formated.odt index de9d92d..1ee40bd 100644 Binary files a/emmy_noether/53_05_en_elan_projectdescription_draft_formated.odt and b/emmy_noether/53_05_en_elan_projectdescription_draft_formated.odt differ diff --git a/emmy_noether/iee99.csl b/emmy_noether/iee99.csl new file mode 100644 index 0000000..42cafdc --- /dev/null +++ b/emmy_noether/iee99.csl @@ -0,0 +1,468 @@ + + diff --git a/emmy_noether/uploaded/Beschreibung_des_Vorhabens_old.pdf b/emmy_noether/uploaded/Beschreibung_des_Vorhabens_old.pdf new file mode 100644 index 0000000..b5bd897 Binary files /dev/null and b/emmy_noether/uploaded/Beschreibung_des_Vorhabens_old.pdf differ diff --git a/emmy_noether/uploaded/Beschreibung_des_Vorhabens_updated.pdf b/emmy_noether/uploaded/Beschreibung_des_Vorhabens_updated.pdf new file mode 100644 index 0000000..04518fa Binary files /dev/null and b/emmy_noether/uploaded/Beschreibung_des_Vorhabens_updated.pdf differ