Project Description – Emmy Noether Programme

Miriam Katharina Brosi, [city]

[Project title]

Project Description
Sections 1-3 must not exceed 17 pages in total.

1	Starting Point

State of the art and preliminary work

[Text]
- radio therapy is an important tool in cancer therapy
- continuous development towards improved tolerability and increase of the therapeutic
window
- two promising developments in recent years:
- encouraging results with very short, high dose beams (FLASH RT)
- recent further development of spatially fractionated RT towards Microbeam Radiation
Therapy (MRT)
- both show improved sparing of healthy tissue and reduction of secondary cancer also
increasingly important due to increase in overall life expectancy
- both are dependent on the use of particle accelerator facilities
- for FLASH: to achieve the required intensity in short pulses, e.g. linear accelerators for
electron FLASH RT
- for MRT: in case of x-ray beams, a high brilliant synchrotron light sources are required to
provide sufficiently parallel propagating Microbeams
- very high requirements on stability and metrology of the used beams

- medical accelerators are tailored to the specific application and need to be rather simple to run without to much maintenance, continuously in the day to day operation.
- new beam modalities such as FLASH and micro-beam therapy have higher requirements on accelerators/source, therefore need to be tested at accelerator research facilities to define/map/study the most suitable parameter set?? before being implemented in a clinical setting
- While research accelerators are more complex they, at the same time, provide much more flexibility and a higher degree of instrumentation
- additionally profit (that they are much more characterized)?/ (from possibility for extensive studies) with regards to more complex beam dynamic effects which become more and more relevant with the push for more complex beam modalities, like shorter pulses (FLASH) or spatially structured beams

- here I can contribute with my experience and research in ...
Me:
- experience in longitudinal as well as transverse collective effects and instabilities
influencing the electron bunch shape in all dimensions
- in general, investigating phenomena occurring under extreme operation modes, e.g. high
charge, small transverse bunch-size, short bunch-length, sub-structures, ...
- on rings but focused on single bunch effects transferrable to linacs
- simulations of non-linear optics and beam dynamics, collective effects
- extensive experimental studies and measurements
- used diagnostics: electron-beam based as well as synchrotron-radiation based (e.g. THz-Schottky diode detectors...)
as well as improved and further-developed diagnostic methods
- data analysis of complex, big datasets with, among others, Python and HPC (high
performance computing
- involve in development and benchmarking/test of new simulation, vlasov-fokker-planck solver based on charge distribution in longitudinal phase-space 

2	Objectives and work programme

2.1	Anticipated total duration of the project

[Text] 6 years

2.2	Objectives

[Text]Motivation:
The present advances in accelerator based RT, like FLASH RT or Microbeam RT, lead to
operation parameters of the used accelerators that can not anymore be described by simple
linear optics and beam dynamics. Instead, due to the development towards higher intensity
combined with shorter pulse lengths and transverse modulations, the consideration of
non-linear and complex optics as well as beam dynamics influenced by collective effects
becomes necessary for accelerator RT sources.
Further closing the gap between accelerator science and medical physics from the accelerator
side is an important step and will help in paving the way towards accurate predictability,
diagnostic and metrology of advanced RT with particle accelerators.

Goals:
- improve predictability of RT beam properties on target by improving understanding of
dynamic in short and/or spatially structured RT beams (!!!spatially structured can be microbeams but also just not round/gaussian beams but more like flat, or narrow, or double peaked, any structure actually that can survive the path through accelerator/be formed at the end of accelerator!!)
- study from accelerator point of view the beam dynamics effects relevant in the generation
of such beams as well as the diagnostic to reliably deliver the requested conditions
- provide start-to-end simulations of the dynamic of RT beams, from inside the accelerator
through the air into the target by combining beam dynamics, beam-matter interaction and
collective effects simulations
- predicting the temporal and spatial shape of each individual RT pulse at any point on the
way up to the target inside the patient

The goal is, by extending the calculation of these effects beyond the accelerator as a first step,
to make the prediction of the resulting spatial distribution on target possible. And as a second
step, it might allow to consider effects of the beam transport already during the generation of
the beam.
Aiming towards the generation of a spatial distribution which preemptively compensates for the
expected changes, possibly allowing arbitrary user-definable final distributions.

2.3	Work programme incl. proposed research methods

Theoretical work:
- literature research of models and methods to propagate structured radiation beams though air and matter, starting from e.g. GEANT4, BDSIM, EGSnrc (with BEAMnrc), ...
- investigate evolution of different temporally and spatially structured radiation beams passing through matter, quantify deterioration of initial structuring based on path length in different materials and initial dimensions and size of structuring (based on requirements in FLASH and microbeam RT)
- literature research on dose deposited by longitudinal and transverse structured beams
- literature research on which effect affect dosimetry of ultra short, high intensity dose rate beams
- ?develop model based on measurements in publication and extend to higher dose rates/shorter pulses?

Simulations:
- evaluate the different operation modes of FLUTE (varying pulse length and charge) with respect towards dose rate of final electron beam, with e.g. FLUKA/EGSnrc
- simulate the 6D particle distribution expected at the exit of the linear
accelerator, employing e.g. ASTRA (gun to start compressor with Space charge) and OCELOT (through compressor with CSR)
	-simulate different possibilities to achieve structure beam at exit:
	- spatial light modulator also used for longitudinal modulation via spectral modulation?
	- energy modulation turned spatial with spectrometer magnet at exit
	- ?
- followed by simulation of the beam dynamics for this particle distribution on its trajectory
to the target, based on existing simulation tools and models, e.g. transport/covariance matrices combined with average scattering angles based on existing beam-matter interaction descriptions
- study deformation of the temporal and spatial distribution on the way through the accelerator and outside on the way to the target under the influence of collective effects, e.g. space charge and the influence of impedances
	- sometimes simulation of particles with matter interaction only (e.g. only linear boltzman 	equation in kit-rt?), not with each other. Here add collective effects based on knowledge 	from accelerator, eg. space charge...(what else is there without magnets/bends?)
- Investigate link between starting distribution and output beam structure exists, by starting with custom, artificial test structures and simulate resulting structure at output, can the transformation be calculated without using particle tracking. (input of knowledge of accelerator optics/model is okay)
- develop calculation to define starting distributions in order to achieve specific output distributions (which could be based on requested beam structures defined by the results in RT developments)
-
- simulate the differences in deposited dose (2D) depending on initial distribution accelerator as well as in dependence on inclusion of the collective effects during beam transport.
- create combined simulation which includes all three parts the beam dynamic in the accelerator and the propagation through matter to the target and finally the deposited dose.

Experimental:
- survey of required vs available diagnostics to measure/determine 6D particle distribution at different positions in the linac, e.g. virtual diagnostic available
- measurements of 6D particle distribution at accelerator exit and investigate dependence on accelerator parameters, e.g. pulse length, charge, starting distribution
	test different possibilities to achieve structure beam at exit:
	- masks?
	- spatial light modulator also used for longitudinal modulation via spectral modulation?
	- energy modulation turned spatial with spectrometer magnet at exit
	- zwei quads to blow up and then collimate beam with the bigger size
	- use SLM to change spot on cathode shot by shot, and therefore, change (e.g.) scan e 	beam. is this simpler, than scanning with a magnet?
- set up necessary diagnostic/detectors/targets for dose rate measurement in air and in a water target (including market survey and acquisition)
- investigate dependence of measured dose on accelerator parameters such as pulse length, charge, longitudinal/transverse structure? ENERGY! ...
- expand setup to allow for detection of spatial distribution, (could be film Kodak XV-2 silver halide radiographic film and thermoluminescent dosimeter TLD-100 as in (https://doi.org/10.1016/S0958-3947(02)00086-9)) or what about a detector like (27x27cm? Oder doch 4x4cm??  https://www.ptwdosimetry.com/en/products/octavius-detector-1500
- experimental studies of the propagation of 6D particle distribution through air and/or
water, structuring done by mask at accelerator exit as well as structured by gun or dynamic in linac

- extend studies to X-ray(/THz?) at synchrotron light source (KARA)????????
for micro beams, normally used mask, probably no way to get electrons per-structured???
for FLASH, problem high reprate? 
- and/or electrons from Lpaccelerator…
- hit tests mit protonen? (was testen)

Periodical cross-checks between experimental results and simulations to iteratively improve both

TODO: 
- use detector that allows for 2d transverse distribution measurement….or can 2d dose be calculated from 2d distribution measurement with e.g. screen?? how does longitudinal distribution affect this????
- MASTER STUDENTS? Chance for postdoc to collect experience in supervising students…
folgende punkte offen wo master student passt und bekomme weil vorlesung halten.../praktikum...(vlt auch versuch erneuern...)
--------------
starting point: 
me (year 1): review of existing simulation tools and methods on accelerator side as well as on beam matter interaction side….starting point electron beam from FLUTE 

phd1 (year 1&2&3): experimental setup and diagnostic for structured electron beam at/after flute, extend beyond accelerator and into phantom/target/ ….charge distribution outside vaccum/after matter interaction & dosimetry, ...dependence on structured beam...see in plan
→ provide input for simulations and later cross-checks with simulation based on measurement results

me (year1) find postdoc 
postdoc(year 2&3): extend and combine simulations and new implement new methods to propagate structured beams through matter interaction, based on the existing simulations like MC but also transport matrix stuff, include not only single electron matter effects but also consider collective effects during transport through matter for electrons
?think about x-rays from KARA?

me(year 2&3)???think about x-rays from KARA? 

(Somewhere I could do something with systematic simulation (computational experiments) using high performance computing???)

((ALTERNATIVE: I do postdoc as described above, and postdoc does improvements on (time-resolved?) dosimetry…for ultra short pulses, would need to be detector engineer ….))

Phd2 (year4&5&6): 
based on previous results work on algorithm/method to adjust starting distribution in such a way that the a certain “requested” distribution on target is achieved by pre-compensating(??) the expected effects of transport through accelerator and matter….

me(year 4&5&6) ???
((ALTERNATIVE year 4-6: using Cstart for “energy scanning” and “pulse length” scanning measurement, to test effects on beam matter interaction during transport of structured beams and dosimetry...For this out-coupling of electrons necessary at cstart))

interface zwischen simulation und messung, 
multi-facceded simulation, mutli-stage

state of the art, vs was ich nach mir, was möchte ich addressieren, was möchte lösen
allein stellungsmerkmal herausarbeiten

ganz konkret was sind die probleme die zu adressieren sind, was sind die wow effekte
space charge, micro-bunching, übergangsstrahlung (bei material wechsel) 
viele kleine punkte (vergleich pepperpot emittance messen, andree diss)
raumladung bei detektion
statistische lösung, strahl als ensemble, beam als ensemble, streueigenschaften, reihe streuung, matirxmultiplikationen. Covariance matrix ansatz (statistische matrizen)…

diagnostic problem, durch kurz strahl pulse

2.4	Handling of research data

The research data produced in this project will cover a wide variety of data types, sizes and formats. Measurement data will originate from the multitude of accelerator beam diagnostic system such as charge measurement, beam position information, transversal bunch profiles monitors or gun laser parameters, as well as from dose measurements in the water phantom. Estimating the total amount of measurement data to be generated over the course of the 6 year project duration results in several TBytes due to the multitude of diagnostics continuously running during the accelerator experiments combined with systematic parameter scans including imaging data from 2D profile measurements.  
Simulation will be conducted with multiple existing simulation tools like EGSnrc, FLUKA, ASTRA or Ocelott (add citation!). Furthermore, results from theoretical calculations such as self implemented simulation tools are expected and will contribute to the resulting research data as well as the developed software tools themselves. Due to the use of particle tracking simulation tools and the possibility to run simulations on a HPC cluster, the estimated amount of simulation data is also in the range of several TBytes. 
The file formats will depend on the diagnostic systems or simulation tools and can range from for example TXT, PNG, JSON or CSV to proprietary file formats such as MAT (Matlab) or custom binary file-formats. If the original format is not easily accessible and/or additional metadata should be saved with the original data, the data will be transferred into files of the hdf5 file-format (Hierarchical Data Format version 5). In the past, the applicant has/ I have ???used the hdf5 file-format extensively and it has proven to be very useful to store complex data, as it is accessible with a wide variety of programming languages (e.g. Python, Matlab, C++) and provides the possibility for internal structuring the stored data in groups, multi-dimensional datasets and amend each substructure with attributes. This allows the collection of connected data, such as the output of different diagnostic tools during one experiment, as well as the addition of metadata. In this way all the information from different sources needed to evaluate measurement results including information about the used instrument types, configuration and settings and furthermore operational parameters of the accelerator. The same principle can be applied to data resulting from calculations and simulations. In this case, it is possible to for example save different derived properties of the simulation output additionally to the simulation results or combine output given in multiple files into one. And furthermore, to keep the context of the simulation and improve the re-usability, all the simulation input parameters and settings can be stored as metadata in the attributes of the hdf5-files.  Also in cases, where the stored data is not in SI units conversion factors can be included in the metadata. In cases where the read-out software or the simulation tool will be programmed from scratch, the hdf5 file-format will be used directly. A consistent filename convention will be implemented including the date (in the human readable date format ISO8601), a short name for the detector respective the simulation tool, and further information. Additional information relevant for later analysis or re-use of the data will be, as mentioned earlier, saved as metadata, either live during the measurement, for example, by reading accelerator parameters provided online from the accelerator control-system (EPICS) (always including Unix timestamps for each added parameter) or, alternatively, added later on in post-processing. All relevant accelerator settings, parameters or properties are by design saved continuously in a Casandra database. A corresponding post-processing workflow can be based on an existing Python framework developed by the applicant/me?? which was successfully used to process more than 50 TByte of measurement data during the PhD studies. 
To document the conducted experiments, the digital logbook ELOG will be used. Originally developed at the Paul Scherrer Institut (Switzerland) under the GNU Public License, it is used in multiple accelerator facilities as a documentation standard. Small data files can be directly linked to the corresponding entries. Larger files will be stored in structured directories on a file server of the institute and a link to the storage location will be added to the ELOG entry. For documentations exceeding the logging during individual measurements, an instance of a wiki is available at the institute. Sub-spaces for individual teams can be created with corresponding access rights. There, information or discussions regarding multiple measurements or simulations can be stored. Within the framework of scientific research, regular comparisons between simulated and measured data will be performed to ensure consistency and increase data quality. Furthermore regular reference measurements at well known conditions are performed to characterize the detection chains. Regular meetings and discussions on the acquired data will be held to minimize human bias (four eyes principle). For the development of software a GitLab instance will be used. This provides a version controlled and simple possibility to save, transfer and jointly work on source codes. With the usage of GIT (distributed version control system), there is also the possibility to implement basic quality control mechanisms, e.g. git hook frameworks like pre-commit, which check the integrity of the source code before committing. For all python scripts the PEP8 coding-style convention will be respected. 
For immediate storage during the runtime of the project, the data will be saved on the institute’s own servers which are equipped with backups and allow to manage the access rights via user-groups. A specific group directory would be created with a systematic folder structure to allow the storage of the generated measurement and simulation data sorted by type and date. In addition to ensure minimal data loss every personal pc of group members will be equipped with an external backup harddrive and each member will be instructed to perform regular backups.
For long-term storage and archival of data the multi-petabyte storage systems of the host institution (e.g. LSDF) including the archival on tape storage will be used. A minimum storage period of 10 years is default for these services. Those are provided by the host institution at no cost. In addition, RADAR4KIT, a research data repository, can be used to, to bundle data and metadata, store and archive this data with the possibility to provide public access later on. For publications, high-level derivative data can be added as supplementary material on the journal web-page. For simulation data, produced with publicly available simulation code, the minimal set of parameters to recreate the simulations will be added. The corresponding full data sets can be published in KITopen via RADAR4KIT, receive a DOI and is open access. Software developed in the framework of this project is planned to be open-source and published on services such as GitHub.
Members of the project group will be provided with the possibility to learn the usage of technologies regarding data management used for the project. Due to the continuous availability throughout the project and previous experiences with large data and software management, the applicant will take on the task of coordinating the handling of research data for the project supported by the IT team of the host institute. Since the usage of established storage solutions is foreseen, the long-term storage and archival responsibility after the project ends lies with KIT.
Research data management within the project as well as the used services will conform to the guidelines published by KIT (“Guidelines for Responsible and Sustainable Research Data Management at KIT (RDM Policy)”) as well as the DFG code of conduct, and the EU open science policy.

2.5	Relevance of sex, gender and/or diversity

[Text] not relevant for proposed project content, but want to contribute to ….diversity in gender, background, nationality, ….by…
welcoming and inclusive work environement for international researchers (international office KIT?) (as I have experienced it during my time abroad) for example by establishing the group internal comunication in German and English, and ...
want to be an excample and role model for young female researchers/young women in science(?) and inform and enable possible female students/group members to join workshops/conferences towards female researchers …EXAMPLE (something that does not cost and does not take away from the male students)

2.6	Justification for the choice of host institution(s)
Please justify the choice of each proposed host institution.

The Karlsruhe Institute of Technology (KIT) would provide an exceptionally well-suited research environment with an unique combination of multidisciplinary research infrastructure and strategic collaborations within the multitude of institutes in complementary research fields as well as with external institutions.  
The KIT is one of the eleven “Universities of Excellence” in Germany. It is unique in that it combines a university and a national research laboratory (in the Helmholtz Association) within one entity resulting in one of the biggest science institutions in Europe. These conditions provide the opportunity to combine academic and fundamental research with application-based and goal-oriented research. KIT offers the possibility to profit from the motivation and ingenuity of students and early-carrier researchers and at the same time gives access to large-scale research facilities. The excellent research at KIT covers among others the disciplines of natural and engineering sciences. Interdisciplinary KIT Centers bring together scientists from different institutes to cross-divisionally tackle challenges and research actives connected to the further development and technological improvement of society. This quest naturally leaves KIT striving to push also the advancement of medical technologies. As newest of the nine KIT Centers, the Center “Health Technologies” has recently been established in March 2023 aiming to “provide next generation innovation for the global health challenges of today and tomorrow”.
Another piece of the puzzle is the research bridge “Medical Technology for Health (MTH)” with the aim to combine knowledge from engineering sciences, molecular basic research and bio-informatics with medical expertise to develop better diagnostics and therapy. The bridge is part of the longstanding strategic partnership with the Heidelberg University HEIKA (Heidelberg Karlsruhe Strategic Partnership) which was initiated in order to combine the complementary competencies of the two Universities. Furthermore, a joint master program in medical engineering in cooperation with the University Heidelberg is planned to start in the winter semester 24/25. 
- Hilft weil bringt die medicine componente mit rein...
- aufbruchstimmung gut um eine gruppe and der schnittstelle zwischen beschleuiniger und eben medizinischer technology zu etablieren und bietet viele wachstums möglichkeiten im sinne von Kollaborationen mit instituten und experten außerhalb des eigenen forschungsfeldet ….
- potential to contribute to this new focus point …..
- auch lehre super da diese themen auch attractive für viele neue studenten sein wird...
- collaboration with uniklinikum Heidelberg???

The Accelerator Technology Platform (ATP) at KIT combines KIT internal expertise and infrastructures relevant for accelerator research, development and application. This not only includes the KIT based accelerators FLUTE and KARA (see below), experts in accelerator physics (IBPT) and accelerator relevant technologies like the Magnet Characterization Facilities (MCF) and cryogenic research laboratories, but furthermore it also includes experts and infrastructure on advanced detector technologies studying for example ultra-fast and radiation hard detection systems. 
All the above is planned to serve as a foundation for a new Cluster of Excellence called AccelerateRT, aiming for basic research towards a more effective, efficient and widely available radiotherapy by focusing on tailored compact accelerators, corresponding beam control, dosimetry and visualization and the resulting bio-medical effects of novel radiotherapy qualities.

With the experimental part of the proposed project relying on the possibility to conduct systematic measurement on accelerators and beams, KIT with the Institute for Beam Physics and Technology (IBPT) is an ideal environment in that it provides easy and extended access for in-house researchers to its electron accelerators. Both accelerators serve as accelerator test facilities for a variety of accelerator physics studies, leading to a high flexibility in available operation modes and beam conditions and the possibility to tailor operation modes to experimental requirements. To this end the accelerators are equipped with extensive, state of the art diagnostics and continuously serve as a test-bed for research towards novel and improved diagnostic methods.  
The 2.5 GeV storage ring and synchrotron light source KARA (Karlsruhe Research Accelerator) is based on the ANKA (Angströmquelle Karlsruhe) which started operation in 2003 and which has been improved continuously since then. KARA provides short-pulsed x-ray modalities at multiple beam lines. Further more, additional operation modes have been implemented at different electron energies such as for example a short-pulse operation allowing the investigation of the dynamics in short electron bunches [Quelle mit mir?] as well as the development and tests of novel, fast diagnostic methods [auch Quelle mit mir?]. 
The second accelerator at KIT-IBPT is the linear electron accelerator FLUTE (Ferninfrarot Linac- und Test-Experiment). It is designed to provide ultra-short electron pulses with an energy of around 6 MeV after the low-energy section and with energies of up to 50 MeV and bunch lengths down to femtoseconds after the full accelerator. Furthermore, FLUTE provides coherent radiation in ultra-short, very intense light pulses from terahertz to far-infrared and beyond. The electrons pulses in FLUTE are generated with a femtosecond chirped laser-driven photo-injector. Recent studies include the application of machine learning for accelerator tuning tasks based on reinforcement learning as well as extend the existing diagnostics with virtual diagnostics achieved by surrogate modeling of the electron beam dynamics. Also of great importance is the recent implementation of a spatial light-modulator which allows spatial and temporal shaping of the laser pulse on the photo-cathode and therefore control of the initial electron distribution in the accelerator. 
ADD SPLIT RING RESONATOR FOR BUNCH LENGTH MEASUREMENT?
CRUCIAL FOR PROJECT…. 
PERFECT FOR INVESTIGATIONS OF FLASH LIKE RT BEAM MODALITIES...

Besides the two existing accelerators, two more are planned to be build within the near future. A 50 MeV laser-plasma accelerator is being build as part of the ATHENA project in collaboration with DESY and the Helmholtz Institute Jena (HIJ). This will open the opportunity to test the developed simulation and diagnostic methods to a different type of accelerator and investigate the possibilities and limitations of LPA beams for radiotherapy. Last but not least, an innovative non-equilibrium storage ring with a wide energy acceptance will be build and will be able to accept both, the LPA as well as FLUTE, as injector. Storing the sub-picosecond to femtosecond short beams will lead to continuous electron bunch lengthening over the revolutions and will provide the possibility to study the effects of different pulse lengths on the detected dosage. 

IBPT -AI? Help with computations and modeling?
Even tough alma mater – unparalleled opportunities, due to unique environment at KIT….
Strong advantage as provides accelerator based high-intensity x-ray beams as well as ultra-short pulse electron beams at the same institution…..
perfect fit for experimental part, and due to many existing centers, clusters, and collaborations great, nurturing environment also for multi-disciplinary input and solutions.

3	Project- and subject-related list of publications
Works cited from sections 1 and 2, both by the applicant and by third parties. Please include DOI/URL if available. A maximum of ten of your own works cited may be highlighted; font at least Arial 9 pt.

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4	Supplementary information on the research context
Section 4 et seq. must not exceed 8 pages.

4.1	Ethical and/or legal aspects of the project

4.1.1	General ethical aspects

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4.1.2	Descriptions of proposed investigations involving humans, human materials or identifiable data

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4.1.3	Descriptions of proposed investigations involving experiments on animals

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4.1.4	Descriptions of projects involving genetic resources (or associated traditional knowledge) from a foreign country

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4.1.5	Explanations regarding any possible safety-related aspects (“Dual Use Research of Concern; foreign trade law)

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4.2	Employment status information
Last name, first name, and employment status (including duration of contract and funding body, if on a fixed-term contract)

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4.3	Composition of the project group
List only those individuals who will work on the project but will not be paid out of the project funds. State each person’s name, academic title, employment status, and type of funding.

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4.4	Researchers in Germany with whom you have agreed to cooperate on this project

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4.5	Researchers abroad with whom you have agreed to cooperate on this project

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4.6	Researchers with whom you have collaborated scientifically within the past three years
This information will help avoid potential conflicts of interest.

MAX IV, University Lund, Sweden: Dr. Pedro Fernandes Tavares, Dr. Åke Andersson
PhLAM, University Lille, France: Prof. Dr. Serge Bielawski, Dr. Christophe Szwaj
KIT, Germany: Prof. Dr. Anke-Susanne Müller, Dr. Erik Bründermann

4.7	Project-relevant cooperation with commercial enterprises
If applicable, please note the EU guidelines on state aid or contact your research institution in this regard.

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4.8	Project-relevant participation in commercial enterprises
Information on connections between the project and the production branch of the enterprise

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4.9	Scientific equipment
List larger instruments that will be available to you for the project. These may include large computer facilities if computing capacity will be needed. 

FLUTE (is this first time mentioning FLUTE…?)
KARA,....
HPC (Rechenzentrum?) 
"Use of HoreKa ("Hochleistungsrechner Karlsruhe") is free of charge, but the resource has to be acknowleged on all publications." (project proposal needs to be submitted)
bwUniCluster "All members of the shareholder universities can apply for an account. The use of the bwUniCluster is free of charge. "

4.10	Other submissions
List any funding proposals for this project and/or major instrumentation previously sub-mitted to a third party. 

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4.11	Other Information
Please use this section for any additional information you feel is relevant which has not been provided elsewhere.

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5	Requested modules/funds
Explain each item (stating last name, first name)

5.1	Module Junior Research Group Leader
Use this module to request funding for your position as project leader under the Emmy Noether Programme.

Clinician scientists may apply for a temporary substitute position instead of a position as junior research group leader. The relevant module can be found on the list of modules.

[Text] Eigene Stelle

5.2	Basic Module

5.2.1	Funding for Staff

[Text]2 doctoral students (75%), (100% für ingenieur)
1 postdoc 
hiwi? (538Euro job)
Aufgabe (mit verweis auf arbeitsprogram) und ab wann
????(die gewünschte Dauer der Beschäftigung im Vorhaben,
 - die Vertragslaufzeiten sollten in der Regel der Projektlaufzeit entsprechen,
 - bei der Festlegung der Vertragslaufzeiten für wissenschaftliches Personal in der
Qualifizierungsphase sollte das Qualifizierungsziel des Stelleninhabers bzw.
der Stelleninhaberin angemessen berücksichtigt werden.)

5.2.2	Direct Project Costs

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5.2.2.1	Equipment up to € 10,000, Software and Consumables

[Text]
-Safety equipment, like small dosimeters to measure area free after irradiation?
5000?
-building material for eg. halter im water target ?? and similar 
6000? → 1000 pro jahr
- cables, adapter, connectors for readout of detectors…
6000?
- amplifiers, attenuators, for readout
6000?
- humidity measure...

- portable external drives for each group member for backup of the working pc 4x1TB SSD (4x100€=400€)
- desktop PC for new diagnostics 3000€ including at least 4 TB of internal storage
- (laptop kann nicht finanziert werden? Oder doch? 4X2000€=8000€)
- monitors...
=11400

5.2.2.2	Travel Expenses

[Text]Teilnahme Konferenzen (1x pro doctorant, 2x für postdoc, Xx für mich? 
HIDSS4Health. https://www.hidss4health.de summer school

5.2.2.3	Visiting Researchers (excluding Mercator Fellows)

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5.2.2.4	Expenses for Laboratory Animals

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5.2.2.5	Other Costs

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5.2.2.6	Project-related Publication Expenses 

[Text] bis zu 750/Jahr für normale Publikationen (geht das z.b. druckkosten Dissertationen?), oder auch für nenn Buch kapitel oder so?
(PRL ist ehr 3000-3500USD) Nature zwischen 1500-9000 

5.2.3	Instrumentation

5.2.3.1	Equipment exceeding € 10,000

[Text] Dosimetry detectors (e.g. mircoDiamond from PTW) 9000-11000 netto
maybe gest several detectors and also something 2d resolved?

water phantom kleines horizontales 6750€ (großes motoriziertes WP → 52000€)

5.2.3.2	Major Instrumentation exceeding € 50,000

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5.3	Module Temporary Clinician Substitute
Clinician scientists may apply for a temporary substitute position instead of a position as junior research group leader. In addition, this module may be used to finance substitute medical personnel who will assume the patient-care responsibilities of the clinicians participating in your project.

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5.4	Module Mercator Fellows

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5.5	Module Workshop Funding

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5.6	Module Public Relations Funding

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5.7	Module Standard Allowance for Gender Equality Measures
Please detail what measures are planned to promote diversity and equal opportunities.

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5.8	Module Family Allowance

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