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first_sentences.txt
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The present advances in accelerator based RT, like FLASH RT or micro beam RT, The present advances in accelerator based RT, like FLASH RT or microbeam RT,
lead to operation parameters of the accelerator that can not anymore be described lead to operation parameters of the accelerator that can not anymore be described
by simple linear optics and beam dynamics. Instead, the consideration of nonlinear by simple linear optics and beam dynamics. Instead, the consideration of nonlinear
and complex optics as well as beam dynamics influenced by collective effects becomes and complex optics as well as beam dynamics influenced by collective effects becomes
@ -10,7 +10,7 @@ influencing the electron bunch shape in all dimensions....
at rings but focus on single bunch effects can be transferred to linac.. at rings but focus on single bunch effects can be transferred to linac..
simulations as well as experimental studies... simulations as well as experimental studies...
also diagnostics, used electron-beam based as well as synchrotron-radiation based and improved and developed further diagnostic methods ... also diagnostics, used electron-beam based as well as synchrotron-radiation based and improved and developed further diagnostic methods ...
Much data analysis... and investigating new phenomena occuring in extrem operation modes... Much data analysis... and investigating new phenomena occurring in extreme operation modes...
bridge gap between accelerator science and medical physics bridge gap between accelerator science and medical physics
@ -22,21 +22,21 @@ This will allow the prediction of the temporal and spacial shape (shape and leng
the radiation/electron pulse not only at the exit of the accelerator but also at any diagnostic the radiation/electron pulse not only at the exit of the accelerator but also at any diagnostic
on the way and finally also at the target inside the patient. on the way and finally also at the target inside the patient.
beam-matter interaction have been described in the past by covariance matrices...(based on e.g. scattering angles(?)...) beam-matter interaction have been described in the past by covariance matrices...(based on e.g. average scattering angles,...)
which was applied e.g. for thin foils in the beam path. which was applied e.g. for thin foils in the beam path.
This can be applied for calculating the impact of the beam-matter interaction This can be applied and adapted to calculating the impact of the beam-matter interaction
on the beam properties during the transport all the way to the target. on the beam properties during the transport all the way to the target.
the feasibility and the accuracy of predicting the beam properties on target is improved. Therefore, the feasibility and the accuracy of predicting the beam properties on target can be improved.
In case, the spacial structuring of the beam on target is relevant, In case, the spacial structuring of the beam on target is of importance,
it is important to know how the spacial distribution changes along the way from generation to the target. it is critical to know how the spacial distribution changes along the way from generation to the target.
With simulations including the beam-matter interaction as well as collective effects within the beam To this end the beam-matter interaction out side the accelerator will be included in the simulations.
On top of this, calculations of the collective effects occurring within the high intensity beam On top of this, calculations of the collective effects occurring within the high intensity beam
can be added using established(?) algorithms/predictions/theoretical descriptions usually applied will be added by extending established theoretical descriptions usually applied
to beam dynamics calculations within the accelerator. to beam dynamics calculations within the accelerator, to the beam transport outside the accelerator.
The hope is that, by extending the calculation of these effects beyond the accelerator The hope is that, by extending the calculation of these effects beyond the accelerator, as a first step,
it becomes possible to predict the resulting spatial distribution on target.
this can not only be predicted but already considered during the generation. And as a second step, it might allow to consider effects of the beam transport already during the generation.
Ideally, this would allow the generation of a spacial distribution which preemptively compensates for the expected changes. Ideally, this would allow the generation of a spacial distribution which preemptively compensates for the expected changes.
TEST with experiment and iteratively improve model....by testing impact and relevance of different effects TEST with experiment and iteratively improve model....by testing impact and relevance of different effects

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@ -42,7 +42,7 @@
\date{\today} \date{\today}
\title[Proposal]{\Large{Proposal for young research group}} \title[Proposal]{\Large{Bullet points for the proposal for a research group}}
\author[Miriam Brosi ]{Miriam Brosi} \author[Miriam Brosi ]{Miriam Brosi}
\begin{document} \begin{document}
@ -67,8 +67,8 @@
\item both show improved sparing of healthy tissue and reduction of secondary cancer also increasingly important due to increase in overall life expectancy \item both show improved sparing of healthy tissue and reduction of secondary cancer also increasingly important due to increase in overall life expectancy
\item both are dependent on the use of particle accelerator facilities \item both are dependent on the use of particle accelerator facilities
\begin{itemize} \begin{itemize}
\item for FLASH: to achieve the required intensity in short pulses, e.g. linear accelerators for electron RT \item for FLASH: to achieve the required intensity in short pulses, e.g. linear accelerators for electron FLASH RT
\item for MRT: in case of x-ray beams, a high brilliant synchrotron light sources are required to provide sufficiently parallel propagating micro beams \item for MRT: in case of x-ray beams, a high brilliant synchrotron light sources are required to provide sufficiently parallel propagating Microbeams
\end{itemize} \end{itemize}
\item very high requirements on stability and metrology of the used beams \item very high requirements on stability and metrology of the used beams
\end{itemize} \end{itemize}
@ -83,13 +83,13 @@
\end{frame} \end{frame}
\begin{frame}{Motivation for the research group} \begin{frame}{Motivation}
The present advances in accelerator based RT, like FLASH RT or micro beam RT, The present advances in accelerator based RT, like FLASH RT or Microbeam RT,
lead to operation parameters of the used accelerators that can not anymore be described by simple linear optics and beam dynamics. Instead, due to the development towards higher intensity combined with shorter pulse lengths and transverse modulations, the consideration of nonlinear and complex optics as well as beam dynamics influenced by collective effects becomes necessary.\\ lead to operation parameters of the used accelerators that can not anymore be described by simple linear optics and beam dynamics. Instead, due to the development towards higher intensity combined with shorter pulse lengths and transverse modulations, the consideration of nonlinear and complex optics as well as beam dynamics influenced by collective effects becomes necessary.\\
\vspace{0.5cm} \vspace{0.5cm}
Helping to bridging this gap between accelerator science and medical physics from the accelerator side is an important step and will help in paving the way towards the application of... Bridging this gap between accelerator science and medical physics from the accelerator side is an important step and will help in paving the way towards accurate predictability, diagnostic and metrology of advanced RT with particle accelerators.
% aims to greatly improve the applicability of these RT methods in the future. % aims to greatly improve the applicability of these RT methods in the future.
\end{frame} \end{frame}
@ -105,18 +105,24 @@ Helping to bridging this gap between accelerator science and medical physics fro
\begin{frame}{Goals} \begin{frame}{Goals}
\begin{itemize} \begin{itemize}
\item improve metrology by improving understanding of dynamic in short and/or spatially structured radiation therapy beams \item improve predictability of RT beam properties on target by improving understanding of dynamic in short and/or spatially structured RT beams
\item based on existing simulations for beam dynamics and beam-matter interaction provide simulations of the dynamics of RT beams start to end, from inside the accelerator through the air into the target \item study from accelerator point of view the beam dynamics effects relevant in the generation of such beams as well as the diagnostic to reliably deliver the requested conditions
\item experimental studies to iteratively check and improve the simulations \item provide simulations of the dynamic of RT beams start to end, from inside the accelerator through the air into the target by combining beam dynamics, beam-matter interaction and collective effects simulations
\item MORE FROM TXT \item predicting the temporal and spacial shape of the individual RT pulse %not only at the exit of the accelerator but also at any diagnostic
at any point on the way up to the target inside the patient
\end{itemize} \end{itemize}
The hope is that, by extending the calculation of these effects beyond the accelerator as a first step, it becomes possible to predict the resulting spatial distribution on target.
And as a second step, it might allow to consider effects of the beam transport already during the generation.
Ideally, this would allow the generation of a spacial distribution which preemptively compensates for the expected changes.
\end{frame} \end{frame}
\begin{frame}{Existing infrastructure and knowledge (1)} \begin{frame}{Existing infrastructure and knowledge (1)}
Environment: Environment:
\begin{itemize} \begin{itemize}
\item ATP \item ATP - accelerators as well as detector technologies
\item HEIKA \item HEIKA - Heidelberg Karlsruhe Strategic Partnership
\item new KIT Center Health Technologies \item new KIT Center Health Technologies
\item possible Cluster of Excellence AccelerateRT \item possible Cluster of Excellence AccelerateRT
\end{itemize} \end{itemize}
@ -129,40 +135,47 @@ Accelerators:
\end{itemize} \end{itemize}
\item KARA storage ring as synchrotron light source for x-ray (and also THz ?) \item KARA storage ring as synchrotron light source for x-ray (and also THz ?)
\begin{itemize} \begin{itemize}
\item extensive diagnostics \item extensive diagnostics, variable, special operation modes, ...
\end{itemize} \end{itemize}
\item in the planing, CSTART innovative non-equilibrium storage ring will provide the possibility to study dynamics of changing pulse lengths \item in the planing, CSTART innovative non-equilibrium storage ring will provide the possibility to study dynamics of changing pulse lengths
\item laser based source also coming \item coming, laser based accelerator
\end{itemize} \end{itemize}
\end{frame} \end{frame}
\begin{frame}{Existing infrastructure and knowledge (2)} \begin{frame}{Existing infrastructure and knowledge (2)}
Me: Me:
\begin{itemize} \begin{itemize}
\item experience in longitudinal as well as transverse collective effects and instabilities influencing the electron bunch shape in all dimensions....over all investigating phenomena occurring under extreme operation modes, e.g. high charge, small transverse bunch-size, short bunch-length, sub-structures \item experience in longitudinal as well as transverse collective effects and instabilities influencing the electron bunch shape in all dimensions
\item on rings but focus on single bunch effects transferrable to linac.. \item in general, investigating phenomena occurring under extreme operation modes, e.g. high charge, small transverse bunch-size, short bunch-length, sub-structures, ...
\item simulations in non-linear optics and beam dynamics, collective effects \item on rings but focused on single bunch effects transferrable to linacs
\item experimental studies... \item simulations of non-linear optics and beam dynamics, collective effects
\item diagnostics, used electron-beam based as well as synchrotron-radiation based and improved and developed further diagnostic methods ... \item extensive experimental studies and measurements
\item Much data analysis... \item used diagnostics: electron-beam based as well as synchrotron-radiation based\\ as well as improved and further-developed diagnostic methods
\item data analysis of complex and big datasets with, amongst others, Python and HPC (high performance computing)
\end{itemize} \end{itemize}
\end{frame} \end{frame}
\begin{frame}{Plan} \begin{frame}{Plan}
Simulations:
\begin{itemize} \begin{itemize}
\item start with simulations on the 3D charge distribution expected at the exit of the linear accelerator \item start with simulations on the 3D charge distribution expected at the exit of the linear accelerator
\item followed by simulation of the beam dynamics for this charge distribution on its trajectory to the target \item followed by simulation of the beam dynamics for this charge distribution on its trajectory to the target
\begin{itemize} \begin{itemize}
\item based on existing simulation tools and models \item based on existing simulation tools and models, e.g. transport/covariance matrices combined with average scattering angles based on existing beam-matter interaction descriptions
\item based on existing beam-matter interaction descriptions
\end{itemize} \end{itemize}
\item in parallel experimental studies of the 3D charge distribution at the accelerator exit based on starting distribution \item add collective effects, e.g. space charge, via impedances and/or particle tracking
\item experimental studies of the propagation of 3D charge distribution through air and/or water \end{itemize}
Experimental in parallel:
\begin{itemize}
\item survey of required vs available diagnostics to measure 3D charge distribution at different positions in the linac, e.g. virtual diagnostic available
\item measurements of 3D charge distribution at accelerator exit based on starting distribution
\item experimental studies of the propagation of 3D charge distribution through air and/or water, including acquiring and set up of necessary diagnostic/detectors/targets
\item extend studies to X-ray(/THz?) at synchrotron light source (KARA)
\end{itemize} \end{itemize}
periodical cross-checks between experimental results and simulations to iteratively improve both
\end{frame} \end{frame}